A dominant EV71-specific CD4+ T cell epitope is highly conserved among human enteroviruses.
CD4+ T cell-mediated immunity plays a central role in determining the immunopathogenesis of viral infections. However, the role of CD4+ T cells in EV71 infection, which causes hand, foot and mouth disease (HFMD), has yet to be elucidated. We applied a sophisticated method to identify promiscuous CD4...
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Public Library of Science (PLoS)
2012
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oai:doaj.org-article:0ab7a891667943df897793627a69b8712021-11-18T08:05:04ZA dominant EV71-specific CD4+ T cell epitope is highly conserved among human enteroviruses.1932-620310.1371/journal.pone.0051957https://doaj.org/article/0ab7a891667943df897793627a69b8712012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23251663/?tool=EBIhttps://doaj.org/toc/1932-6203CD4+ T cell-mediated immunity plays a central role in determining the immunopathogenesis of viral infections. However, the role of CD4+ T cells in EV71 infection, which causes hand, foot and mouth disease (HFMD), has yet to be elucidated. We applied a sophisticated method to identify promiscuous CD4+ T cell epitopes contained within the sequence of the EV71 polyprotein. Fifteen epitopes were identified, and three of them are dominant ones. The most dominant epitope is highly conserved among enterovirus species, including HFMD-related coxsackieviruses, HFMD-unrelated echoviruses and polioviruses. Furthermore, the CD4+ T cells specific to the epitope indeed cross-reacted with the homolog of poliovirus 3 Sabin. Our findings imply that CD4+ T cell responses to poliovirus following vaccination, or to other enteroviruses to which individuals may be exposed in early childhood, may have a modulating effect on subsequent CD4+ T cell response to EV71 infection or vaccine.Ruicheng WeiChunfu YangMei ZengFrances TerryKai ZhuChunhui YangRalf AltmeyerWilliam MartinAnne S De GrootQibin LengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e51957 (2012) |
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Medicine R Science Q Ruicheng Wei Chunfu Yang Mei Zeng Frances Terry Kai Zhu Chunhui Yang Ralf Altmeyer William Martin Anne S De Groot Qibin Leng A dominant EV71-specific CD4+ T cell epitope is highly conserved among human enteroviruses. |
| description |
CD4+ T cell-mediated immunity plays a central role in determining the immunopathogenesis of viral infections. However, the role of CD4+ T cells in EV71 infection, which causes hand, foot and mouth disease (HFMD), has yet to be elucidated. We applied a sophisticated method to identify promiscuous CD4+ T cell epitopes contained within the sequence of the EV71 polyprotein. Fifteen epitopes were identified, and three of them are dominant ones. The most dominant epitope is highly conserved among enterovirus species, including HFMD-related coxsackieviruses, HFMD-unrelated echoviruses and polioviruses. Furthermore, the CD4+ T cells specific to the epitope indeed cross-reacted with the homolog of poliovirus 3 Sabin. Our findings imply that CD4+ T cell responses to poliovirus following vaccination, or to other enteroviruses to which individuals may be exposed in early childhood, may have a modulating effect on subsequent CD4+ T cell response to EV71 infection or vaccine. |
| format |
article |
| author |
Ruicheng Wei Chunfu Yang Mei Zeng Frances Terry Kai Zhu Chunhui Yang Ralf Altmeyer William Martin Anne S De Groot Qibin Leng |
| author_facet |
Ruicheng Wei Chunfu Yang Mei Zeng Frances Terry Kai Zhu Chunhui Yang Ralf Altmeyer William Martin Anne S De Groot Qibin Leng |
| author_sort |
Ruicheng Wei |
| title |
A dominant EV71-specific CD4+ T cell epitope is highly conserved among human enteroviruses. |
| title_short |
A dominant EV71-specific CD4+ T cell epitope is highly conserved among human enteroviruses. |
| title_full |
A dominant EV71-specific CD4+ T cell epitope is highly conserved among human enteroviruses. |
| title_fullStr |
A dominant EV71-specific CD4+ T cell epitope is highly conserved among human enteroviruses. |
| title_full_unstemmed |
A dominant EV71-specific CD4+ T cell epitope is highly conserved among human enteroviruses. |
| title_sort |
dominant ev71-specific cd4+ t cell epitope is highly conserved among human enteroviruses. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/0ab7a891667943df897793627a69b871 |
| work_keys_str_mv |
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1718422210080669696 |