Drug diffusion and biological responses of arteries using a drug-eluting stent with nonuniform coating

Noboru Saito, Yuhei Mori, Sayaka Uchiyama Terumo Corporation R&D Center, Inokuchi, Nakai-machi, Ashigarakami-gun, Kanagawa, Japan Abstract: The purpose of this study was to determine the effect of a nonuniform coating, abluminal-gradient coating (AGC), which leaves the abluminal surface of...

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Autores principales:	Saito N, Mori Y, Uchiyama S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	drug-eluting stent abluminal coating drug diffusion endothelialization. Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/0ab9a3fb2ad14afc874b14ff7a818471
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spelling	oai:doaj.org-article:0ab9a3fb2ad14afc874b14ff7a8184712021-12-02T02:46:54ZDrug diffusion and biological responses of arteries using a drug-eluting stent with nonuniform coating1179-1470https://doaj.org/article/0ab9a3fb2ad14afc874b14ff7a8184712016-03-01T00:00:00Zhttps://www.dovepress.com/drug-diffusion-and-biological-responses-of-arteries-using-a-drug-eluti-peer-reviewed-article-MDERhttps://doaj.org/toc/1179-1470Noboru Saito, Yuhei Mori, Sayaka Uchiyama Terumo Corporation R&D Center, Inokuchi, Nakai-machi, Ashigarakami-gun, Kanagawa, Japan Abstract: The purpose of this study was to determine the effect of a nonuniform coating, abluminal-gradient coating (AGC), which leaves the abluminal surface of the curves and links parts of the stent free from the drug coating, on the diffusion direction of the drug and the biological responses of the artery to drug-eluting stent (DES) by comparing the AGC-sirolimus stent and the conventional full-surface coating (CFC) sirolimus stent. The study aimed to verify whether the AGC approach was appropriate for the development of a safer DES, minimizing the risks of stent thrombosis due to delayed endothelialization by the drug and distal embolization due to cracking of the coating layer on the hinge parts of the DES on stent expansion. In the in vitro local drug diffusion study, we used rhodamine B as a model drug, and rhodamine B released from the AGC stent diffused predominantly into the abluminal side of the alginate artery model. Conversely, rhodamine B released from the CFC stent quickly spread to the luminal side of the artery model, where endothelial cell regeneration is required. In the biological responses study, the luminal surface of the iliac artery implanted with the AGC-sirolimus stent in a rabbit iliac artery for 2 weeks was completely covered with endothelial-like cells. On the other hand, the luminal surface of the iliac artery implanted with the CFC-sirolimus stent for 2 weeks only showed partial coverage with endothelial-like cells. While thrombosis was observed in two of the three CFC-sirolimus stents, it was observed in only one of the three AGC-sirolimus stents. Taken together, these findings indicate that the designed nonuniform coating (AGC) is an appropriate approach to ensure a safer DES. However, the number of studies is limited and a larger study should be conducted to reach a statistically significant conclusion. Keywords: drug-eluting stent, abluminal coating, drug diffusion, endothelializationSaito NMori YUchiyama SDove Medical Pressarticledrug-eluting stentabluminal coatingdrug diffusionendothelialization.Medical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol 2016, Iss Issue 1, Pp 33-43 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug-eluting stent abluminal coating drug diffusion endothelialization. Medical technology R855-855.5
spellingShingle	drug-eluting stent abluminal coating drug diffusion endothelialization. Medical technology R855-855.5 Saito N Mori Y Uchiyama S Drug diffusion and biological responses of arteries using a drug-eluting stent with nonuniform coating
description	Noboru Saito, Yuhei Mori, Sayaka Uchiyama Terumo Corporation R&D Center, Inokuchi, Nakai-machi, Ashigarakami-gun, Kanagawa, Japan Abstract: The purpose of this study was to determine the effect of a nonuniform coating, abluminal-gradient coating (AGC), which leaves the abluminal surface of the curves and links parts of the stent free from the drug coating, on the diffusion direction of the drug and the biological responses of the artery to drug-eluting stent (DES) by comparing the AGC-sirolimus stent and the conventional full-surface coating (CFC) sirolimus stent. The study aimed to verify whether the AGC approach was appropriate for the development of a safer DES, minimizing the risks of stent thrombosis due to delayed endothelialization by the drug and distal embolization due to cracking of the coating layer on the hinge parts of the DES on stent expansion. In the in vitro local drug diffusion study, we used rhodamine B as a model drug, and rhodamine B released from the AGC stent diffused predominantly into the abluminal side of the alginate artery model. Conversely, rhodamine B released from the CFC stent quickly spread to the luminal side of the artery model, where endothelial cell regeneration is required. In the biological responses study, the luminal surface of the iliac artery implanted with the AGC-sirolimus stent in a rabbit iliac artery for 2 weeks was completely covered with endothelial-like cells. On the other hand, the luminal surface of the iliac artery implanted with the CFC-sirolimus stent for 2 weeks only showed partial coverage with endothelial-like cells. While thrombosis was observed in two of the three CFC-sirolimus stents, it was observed in only one of the three AGC-sirolimus stents. Taken together, these findings indicate that the designed nonuniform coating (AGC) is an appropriate approach to ensure a safer DES. However, the number of studies is limited and a larger study should be conducted to reach a statistically significant conclusion. Keywords: drug-eluting stent, abluminal coating, drug diffusion, endothelialization
format	article
author	Saito N Mori Y Uchiyama S
author_facet	Saito N Mori Y Uchiyama S
author_sort	Saito N
title	Drug diffusion and biological responses of arteries using a drug-eluting stent with nonuniform coating
title_short	Drug diffusion and biological responses of arteries using a drug-eluting stent with nonuniform coating
title_full	Drug diffusion and biological responses of arteries using a drug-eluting stent with nonuniform coating
title_fullStr	Drug diffusion and biological responses of arteries using a drug-eluting stent with nonuniform coating
title_full_unstemmed	Drug diffusion and biological responses of arteries using a drug-eluting stent with nonuniform coating
title_sort	drug diffusion and biological responses of arteries using a drug-eluting stent with nonuniform coating
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/0ab9a3fb2ad14afc874b14ff7a818471
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Drug diffusion and biological responses of arteries using a drug-eluting stent with nonuniform coating

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