Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study

Alopecia areata is an autoimmune, inflammatory form of non-scarring hair loss that may affect any hair-bearing area. Recently, an increased risk of cardiovascular disorders has been described in patients with alopecia areata. The aim of the study was to evaluate the serum concentrations of proinflam...

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Autores principales:	Anna Waśkiel-Burnat, Anna Niemczyk, Leszek Blicharz, Paulina Chmielińska, Michał Zaremba, Aleksandra Gąsecka, Krzysztof J. Filipiak, Małgorzata Olszewska, Lidia Rudnicka
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cardiovascular disease coronary artery disease heart disease hair loss stroke myocardial infarction Medicine R
Acceso en línea:	https://doaj.org/article/0ab9ecccaf2245e085979acbfa300c32
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spelling	oai:doaj.org-article:0ab9ecccaf2245e085979acbfa300c322021-11-25T18:02:37ZChemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study10.3390/jcm102254182077-0383https://doaj.org/article/0ab9ecccaf2245e085979acbfa300c322021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5418https://doaj.org/toc/2077-0383Alopecia areata is an autoimmune, inflammatory form of non-scarring hair loss that may affect any hair-bearing area. Recently, an increased risk of cardiovascular disorders has been described in patients with alopecia areata. The aim of the study was to evaluate the serum concentrations of proinflammatory proteins associated with atherosclerosis (chemokine C-C motif ligand 4; CCL4, chemokine C-C motif ligand 7, CCL7; and sortilin, SORT1), and cardiovascular risk (myeloperoxidase, MPO; interleukin 1 receptor-like 1, IL1RL1; and growth differentiation factor 15, GDF15) in patients with alopecia areata without symptoms or prior cardiovascular disease in comparison with healthy controls. Sixty otherwise healthy patients with alopecia areata and twenty control subjects matched for age, gender, and body mass index (BMI) were enrolled in the study. No significant differences in the serum levels of MPO, IL1RL1, CCL4, CCL7, SORT1, and GDF15 were detected between patients with alopecia areata and healthy controls. A positive correlation was found between the serum concentration of CCL7 and the severity of alopecia areata (r = 0.281, <i>p</i> = 0.03), while GDF15 correlated with age at the disease onset (r = 0.509, <i>p</i> < 0.0001). The results of the present study suggest that the severity of alopecia areata may be associated with an increased risk of atherosclerosis.Anna Waśkiel-BurnatAnna NiemczykLeszek BlicharzPaulina ChmielińskaMichał ZarembaAleksandra GąseckaKrzysztof J. FilipiakMałgorzata OlszewskaLidia RudnickaMDPI AGarticlecardiovascular diseasecoronary artery diseaseheart diseasehair lossstrokemyocardial infarctionMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5418, p 5418 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular disease coronary artery disease heart disease hair loss stroke myocardial infarction Medicine R
spellingShingle	cardiovascular disease coronary artery disease heart disease hair loss stroke myocardial infarction Medicine R Anna Waśkiel-Burnat Anna Niemczyk Leszek Blicharz Paulina Chmielińska Michał Zaremba Aleksandra Gąsecka Krzysztof J. Filipiak Małgorzata Olszewska Lidia Rudnicka Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study
description	Alopecia areata is an autoimmune, inflammatory form of non-scarring hair loss that may affect any hair-bearing area. Recently, an increased risk of cardiovascular disorders has been described in patients with alopecia areata. The aim of the study was to evaluate the serum concentrations of proinflammatory proteins associated with atherosclerosis (chemokine C-C motif ligand 4; CCL4, chemokine C-C motif ligand 7, CCL7; and sortilin, SORT1), and cardiovascular risk (myeloperoxidase, MPO; interleukin 1 receptor-like 1, IL1RL1; and growth differentiation factor 15, GDF15) in patients with alopecia areata without symptoms or prior cardiovascular disease in comparison with healthy controls. Sixty otherwise healthy patients with alopecia areata and twenty control subjects matched for age, gender, and body mass index (BMI) were enrolled in the study. No significant differences in the serum levels of MPO, IL1RL1, CCL4, CCL7, SORT1, and GDF15 were detected between patients with alopecia areata and healthy controls. A positive correlation was found between the serum concentration of CCL7 and the severity of alopecia areata (r = 0.281, <i>p</i> = 0.03), while GDF15 correlated with age at the disease onset (r = 0.509, <i>p</i> < 0.0001). The results of the present study suggest that the severity of alopecia areata may be associated with an increased risk of atherosclerosis.
format	article
author	Anna Waśkiel-Burnat Anna Niemczyk Leszek Blicharz Paulina Chmielińska Michał Zaremba Aleksandra Gąsecka Krzysztof J. Filipiak Małgorzata Olszewska Lidia Rudnicka
author_facet	Anna Waśkiel-Burnat Anna Niemczyk Leszek Blicharz Paulina Chmielińska Michał Zaremba Aleksandra Gąsecka Krzysztof J. Filipiak Małgorzata Olszewska Lidia Rudnicka
author_sort	Anna Waśkiel-Burnat
title	Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study
title_short	Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study
title_full	Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study
title_fullStr	Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study
title_full_unstemmed	Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study
title_sort	chemokine c-c motif ligand 7 (ccl7), a biomarker of atherosclerosis, is associated with the severity of alopecia areata: a preliminary study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0ab9ecccaf2245e085979acbfa300c32
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Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study

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