Relationship Between the TyG Index and Diabetic Kidney Disease in Patients with Type-2 Diabetes Mellitus

Liangjing Lv,1,&ast; Yangmei Zhou,1,&ast; Xiangjun Chen,1 Lilin Gong,1 Jinshan Wu,1 Wenjin Luo,1 Yan Shen,1 Shichao Han,2 Jinbo Hu,1 Yue Wang,1 Qifu Li,1 Zhihong Wang1 On behalf of the Chongqing Diabetes Registry Group1Department of Endocrinology, The First Affiliated Hospital of Chongqing M...

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Autores principales:	Lv L, Zhou Y, Chen X, Gong L, Wu J, Luo W, Shen Y, Han S, Hu J, Wang Y, Li Q, Wang Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	diabetic kidney disease triglyceride–glucose index insulin resistance Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/0ab9ff1cf09745318634476239582bba
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spelling	oai:doaj.org-article:0ab9ff1cf09745318634476239582bba2021-12-02T16:27:17ZRelationship Between the TyG Index and Diabetic Kidney Disease in Patients with Type-2 Diabetes Mellitus1178-7007https://doaj.org/article/0ab9ff1cf09745318634476239582bba2021-07-01T00:00:00Zhttps://www.dovepress.com/relationship-between-the-tyg-index-and-diabetic-kidney-disease-in-pati-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Liangjing Lv,1,&ast; Yangmei Zhou,1,&ast; Xiangjun Chen,1 Lilin Gong,1 Jinshan Wu,1 Wenjin Luo,1 Yan Shen,1 Shichao Han,2 Jinbo Hu,1 Yue Wang,1 Qifu Li,1 Zhihong Wang1 On behalf of the Chongqing Diabetes Registry Group1Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Statistics, University of California, Berkeley, CA, USA&ast;These authors contributed equally to this workCorrespondence: Zhihong WangDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, People’s Republic of ChinaTel/Fax +86-023-89011552Email towzh713@126.comBackground: Diabetic kidney disease (DKD) lacks a simple and relatively accurate predictor. The Triglyceride–Glucose (TyG) Index is a proxy of insulin resistance, but the association between the TyG Index and DKD is less certain. We investigated if the TyG Index can predict DKD onset effectively.Materials and Methods: Cross-sectional and longitudinal analyses were undertaken. In total, 1432 type-2 diabetes mellitus (T2DM) patients were included in the cross-sectional analysis. The TyG Index (calculated by ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]) was split into three tertiles. Associations of the TyG Index with microalbuminuria and estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 were calculated. Longitudinally, 424 patients without DKD at baseline were followed up for 21 (range, 12– 24) months. The main outcome was DKD prevalence as defined with eGFR < 60 mL/min/1.73 m2 or continuously increased urinary microalbuminuria: creatinine ratio (> 30 mg/mL) over 3 months. Cox regression was used to analyze the association between the TyG Index at baseline and DKD. Receiver operating characteristics curve (ROC) analysis was used to assess the sensitivity and specificity of the TyG Index in predicting DKD.Results: In cross-sectional analysis, patients with a higher TyG Index had a higher risk of microalbuminuria (OR = 2.342, 95% CI = 1.744– 3.144, p < 0.001), and eGFR < 60 mL/min/1.73 m2 (1.696, 95% CI =1.096– 2.625, p = 0.018). Longitudinally, 94 of 424 participants developed DKD. After confounder adjustment, patients in the high tertile of the TyG Index at baseline had a greater risk to developing DKD than those in the low tertile (HR = 1.727, 95% CI = 1.042– 2.863, p = 0.034). The area under the ROC curve was 0.69 (0.63– 0.76).Conclusion: The TyG Index is a potential predictor for DKD in T2DM patients.Clinical Trial: Clinical Trials identification number = NCT03692884.Keywords: diabetic kidney disease, triglyceride–glucose index, insulin resistanceLv LZhou YChen XGong LWu JLuo WShen YHan SHu JWang YLi QWang ZDove Medical Pressarticlediabetic kidney diseasetriglyceride–glucose indexinsulin resistanceSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 3299-3306 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic kidney disease triglyceride–glucose index insulin resistance Specialties of internal medicine RC581-951
spellingShingle	diabetic kidney disease triglyceride–glucose index insulin resistance Specialties of internal medicine RC581-951 Lv L Zhou Y Chen X Gong L Wu J Luo W Shen Y Han S Hu J Wang Y Li Q Wang Z Relationship Between the TyG Index and Diabetic Kidney Disease in Patients with Type-2 Diabetes Mellitus
description	Liangjing Lv,1,&ast; Yangmei Zhou,1,&ast; Xiangjun Chen,1 Lilin Gong,1 Jinshan Wu,1 Wenjin Luo,1 Yan Shen,1 Shichao Han,2 Jinbo Hu,1 Yue Wang,1 Qifu Li,1 Zhihong Wang1 On behalf of the Chongqing Diabetes Registry Group1Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Statistics, University of California, Berkeley, CA, USA&ast;These authors contributed equally to this workCorrespondence: Zhihong WangDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, People’s Republic of ChinaTel/Fax +86-023-89011552Email towzh713@126.comBackground: Diabetic kidney disease (DKD) lacks a simple and relatively accurate predictor. The Triglyceride–Glucose (TyG) Index is a proxy of insulin resistance, but the association between the TyG Index and DKD is less certain. We investigated if the TyG Index can predict DKD onset effectively.Materials and Methods: Cross-sectional and longitudinal analyses were undertaken. In total, 1432 type-2 diabetes mellitus (T2DM) patients were included in the cross-sectional analysis. The TyG Index (calculated by ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]) was split into three tertiles. Associations of the TyG Index with microalbuminuria and estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 were calculated. Longitudinally, 424 patients without DKD at baseline were followed up for 21 (range, 12– 24) months. The main outcome was DKD prevalence as defined with eGFR < 60 mL/min/1.73 m2 or continuously increased urinary microalbuminuria: creatinine ratio (> 30 mg/mL) over 3 months. Cox regression was used to analyze the association between the TyG Index at baseline and DKD. Receiver operating characteristics curve (ROC) analysis was used to assess the sensitivity and specificity of the TyG Index in predicting DKD.Results: In cross-sectional analysis, patients with a higher TyG Index had a higher risk of microalbuminuria (OR = 2.342, 95% CI = 1.744– 3.144, p < 0.001), and eGFR < 60 mL/min/1.73 m2 (1.696, 95% CI =1.096– 2.625, p = 0.018). Longitudinally, 94 of 424 participants developed DKD. After confounder adjustment, patients in the high tertile of the TyG Index at baseline had a greater risk to developing DKD than those in the low tertile (HR = 1.727, 95% CI = 1.042– 2.863, p = 0.034). The area under the ROC curve was 0.69 (0.63– 0.76).Conclusion: The TyG Index is a potential predictor for DKD in T2DM patients.Clinical Trial: Clinical Trials identification number = NCT03692884.Keywords: diabetic kidney disease, triglyceride–glucose index, insulin resistance
format	article
author	Lv L Zhou Y Chen X Gong L Wu J Luo W Shen Y Han S Hu J Wang Y Li Q Wang Z
author_facet	Lv L Zhou Y Chen X Gong L Wu J Luo W Shen Y Han S Hu J Wang Y Li Q Wang Z
author_sort	Lv L
title	Relationship Between the TyG Index and Diabetic Kidney Disease in Patients with Type-2 Diabetes Mellitus
title_short	Relationship Between the TyG Index and Diabetic Kidney Disease in Patients with Type-2 Diabetes Mellitus
title_full	Relationship Between the TyG Index and Diabetic Kidney Disease in Patients with Type-2 Diabetes Mellitus
title_fullStr	Relationship Between the TyG Index and Diabetic Kidney Disease in Patients with Type-2 Diabetes Mellitus
title_full_unstemmed	Relationship Between the TyG Index and Diabetic Kidney Disease in Patients with Type-2 Diabetes Mellitus
title_sort	relationship between the tyg index and diabetic kidney disease in patients with type-2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/0ab9ff1cf09745318634476239582bba
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Relationship Between the TyG Index and Diabetic Kidney Disease in Patients with Type-2 Diabetes Mellitus

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