Obesity and Race May Explain Differential Burden of White Matter Hyperintensity Load

Azizi A Seixas,1,2 Arlener D Turner,2 Omonigho Michael Bubu,1,2 Girardin Jean-Louis,1,2 Mony J de Leon,3 Ricardo S Osorio,2 Lidia Glodzik3 1New York University Grossman School of Medicine, Department of Population Health, New York, NY, 10016, USA; 2New York University Grossman School of Medicine, De...

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Autores principales:	Seixas AA, Turner AD, Bubu OM, Jean-Louis G, de Leon MJ, Osorio RS, Glodzik L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	white matter hyperintensities (wmh) racial/ethnic differences african american obesity Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/0abaeacac4e64dc0b3dcad66cdf53662
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spelling	oai:doaj.org-article:0abaeacac4e64dc0b3dcad66cdf536622021-12-02T16:46:27ZObesity and Race May Explain Differential Burden of White Matter Hyperintensity Load1178-1998https://doaj.org/article/0abaeacac4e64dc0b3dcad66cdf536622021-08-01T00:00:00Zhttps://www.dovepress.com/obesity-and-race-may-explain-differential-burden-of-white-matter-hyper-peer-reviewed-fulltext-article-CIAhttps://doaj.org/toc/1178-1998Azizi A Seixas,1,2 Arlener D Turner,2 Omonigho Michael Bubu,1,2 Girardin Jean-Louis,1,2 Mony J de Leon,3 Ricardo S Osorio,2 Lidia Glodzik3 1New York University Grossman School of Medicine, Department of Population Health, New York, NY, 10016, USA; 2New York University Grossman School of Medicine, Department of Psychiatry, New York, NY, 10016, USA; 3Weill Cornell Medicine, Department of Radiology, New York, NY, 10021, USACorrespondence: Azizi A SeixasDepartments of Population Health and Psychiatry, New York University Grossman School of Medicine, 180 Madison Avenue, Office # 715, New York, NY, 10016, USATel +1 646-501-3430Fax +1 212-263-4595Email Azizi.Seixas@nyulangone.orgObjective: Compared to European Americans, research indicates that African Americans have higher white matter hyperintensity (WMH) load; however, the clinical and biological bases underlying this higher burden are poorly understood. We hypothesize that obesity may explain differences in WMH between African and European Americans.Methods: Participants enrolled in longitudinal brain aging studies (n=292; 61% Female; 92% European American; mean age=69.6± 7.7) completed evaluations including medical exams, neuroimaging, and sociodemographic surveys. Overweight/obese status defined as body mass index ≥ 30 kg/m2, and WMH load, captured by FLAIR images, as sum of deep and periventricular volumes, scored using the Fazekas scale (0– 6), WMH≥ 4 considered high.Results: Logistic regression analyses, adjusted for age, sex, hypertension, and smoking history, indicated that age and interaction between race and obesity were significant predictors of WMH, demonstrating that obesity significantly moderated the relationship between race and WMH. Age independently increased the odds of high WMH by 16% (OR=1.16, 95% CI=1.09– 1.23, p< 0.001). Stratified analysis indicates that older European Americans had increased WMH (OR=1.17, 95% CI=1.09– 1.23, p< 0.001), while obese African Americans had increased WMH (OR=27.65, 95% CI=1.47– 519.13, p< 0.05). In a case controlled subgroup matched by age, sex, and education (n=48), African Americans had significantly higher WMH load (27% vs 4%, &KHgr;2=5.3, p=0.02).Conclusion: Results denote that age predicted WMH among European Americans, while obesity predicted WMH among African Americans. Matched sample analyses indicate that obesity increases the odds of WMH, though more pronounced in African Americans. These findings suggest that obesity may explain the differential burden of white matter hyperintensity load, signifying public health and clinical importance.Keywords: white matter hyperintensities, WMH, racial/ethnic differences, African American, obesitySeixas AATurner ADBubu OMJean-Louis Gde Leon MJOsorio RSGlodzik LDove Medical Pressarticlewhite matter hyperintensities (wmh)racial/ethnic differencesafrican americanobesityGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 1563-1571 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	white matter hyperintensities (wmh) racial/ethnic differences african american obesity Geriatrics RC952-954.6
spellingShingle	white matter hyperintensities (wmh) racial/ethnic differences african american obesity Geriatrics RC952-954.6 Seixas AA Turner AD Bubu OM Jean-Louis G de Leon MJ Osorio RS Glodzik L Obesity and Race May Explain Differential Burden of White Matter Hyperintensity Load
description	Azizi A Seixas,1,2 Arlener D Turner,2 Omonigho Michael Bubu,1,2 Girardin Jean-Louis,1,2 Mony J de Leon,3 Ricardo S Osorio,2 Lidia Glodzik3 1New York University Grossman School of Medicine, Department of Population Health, New York, NY, 10016, USA; 2New York University Grossman School of Medicine, Department of Psychiatry, New York, NY, 10016, USA; 3Weill Cornell Medicine, Department of Radiology, New York, NY, 10021, USACorrespondence: Azizi A SeixasDepartments of Population Health and Psychiatry, New York University Grossman School of Medicine, 180 Madison Avenue, Office # 715, New York, NY, 10016, USATel +1 646-501-3430Fax +1 212-263-4595Email Azizi.Seixas@nyulangone.orgObjective: Compared to European Americans, research indicates that African Americans have higher white matter hyperintensity (WMH) load; however, the clinical and biological bases underlying this higher burden are poorly understood. We hypothesize that obesity may explain differences in WMH between African and European Americans.Methods: Participants enrolled in longitudinal brain aging studies (n=292; 61% Female; 92% European American; mean age=69.6± 7.7) completed evaluations including medical exams, neuroimaging, and sociodemographic surveys. Overweight/obese status defined as body mass index ≥ 30 kg/m2, and WMH load, captured by FLAIR images, as sum of deep and periventricular volumes, scored using the Fazekas scale (0– 6), WMH≥ 4 considered high.Results: Logistic regression analyses, adjusted for age, sex, hypertension, and smoking history, indicated that age and interaction between race and obesity were significant predictors of WMH, demonstrating that obesity significantly moderated the relationship between race and WMH. Age independently increased the odds of high WMH by 16% (OR=1.16, 95% CI=1.09– 1.23, p< 0.001). Stratified analysis indicates that older European Americans had increased WMH (OR=1.17, 95% CI=1.09– 1.23, p< 0.001), while obese African Americans had increased WMH (OR=27.65, 95% CI=1.47– 519.13, p< 0.05). In a case controlled subgroup matched by age, sex, and education (n=48), African Americans had significantly higher WMH load (27% vs 4%, &KHgr;2=5.3, p=0.02).Conclusion: Results denote that age predicted WMH among European Americans, while obesity predicted WMH among African Americans. Matched sample analyses indicate that obesity increases the odds of WMH, though more pronounced in African Americans. These findings suggest that obesity may explain the differential burden of white matter hyperintensity load, signifying public health and clinical importance.Keywords: white matter hyperintensities, WMH, racial/ethnic differences, African American, obesity
format	article
author	Seixas AA Turner AD Bubu OM Jean-Louis G de Leon MJ Osorio RS Glodzik L
author_facet	Seixas AA Turner AD Bubu OM Jean-Louis G de Leon MJ Osorio RS Glodzik L
author_sort	Seixas AA
title	Obesity and Race May Explain Differential Burden of White Matter Hyperintensity Load
title_short	Obesity and Race May Explain Differential Burden of White Matter Hyperintensity Load
title_full	Obesity and Race May Explain Differential Burden of White Matter Hyperintensity Load
title_fullStr	Obesity and Race May Explain Differential Burden of White Matter Hyperintensity Load
title_full_unstemmed	Obesity and Race May Explain Differential Burden of White Matter Hyperintensity Load
title_sort	obesity and race may explain differential burden of white matter hyperintensity load
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/0abaeacac4e64dc0b3dcad66cdf53662
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Obesity and Race May Explain Differential Burden of White Matter Hyperintensity Load

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