Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review.

<h4>Background</h4>Zika virus (ZIKV) has generated global interest in the last five years mostly due to its resurgence in the Americas between 2015 and 2016. It was previously thought to be a self-limiting infection causing febrile illness in less than one quarter of those infected. Howe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sheliza Halani, Panashe E Tombindo, Ryan O'Reilly, Rafael N Miranda, Laura K Erdman, Clare Whitehead, Joanna M Bielecki, Lauren Ramsay, Raphael Ximenes, Justin Boyle, Carsten Krueger, Shannon Willmott, Shaun K Morris, Kellie E Murphy, Beate Sander
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/0abe5e62ad22415c8d5b812135c2e174
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0abe5e62ad22415c8d5b812135c2e174
record_format	dspace
spelling	oai:doaj.org-article:0abe5e62ad22415c8d5b812135c2e1742021-11-25T06:33:31ZClinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review.1935-27271935-273510.1371/journal.pntd.0009516https://doaj.org/article/0abe5e62ad22415c8d5b812135c2e1742021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009516https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Zika virus (ZIKV) has generated global interest in the last five years mostly due to its resurgence in the Americas between 2015 and 2016. It was previously thought to be a self-limiting infection causing febrile illness in less than one quarter of those infected. However, a rise in birth defects amongst children born to infected pregnant women, as well as increases in neurological manifestations in adults has been demonstrated. We systemically reviewed the literature to understand clinical manifestations and health outcomes in adults globally.<h4>Methods</h4>This review was registered prospectively with PROPSERO (CRD 42018096558). We systematically searched for studies in six databases from inception to the end of September 2020. There were no language restrictions. Critical appraisal was completed using the Joanna Briggs Institute Critical Appraisal Tools.<h4>Findings</h4>We identified 73 studies globally that reported clinical outcomes in ZIKV-infected adults, of which 55 studies were from the Americas. For further analysis, we considered studies that met 70% of critical appraisal criteria and described subjects with confirmed ZIKV. The most common symptoms included: exanthema (5,456/6,129; 89%), arthralgia (3,809/6,093; 63%), fever (3,787/6,124; 62%), conjunctivitis (2,738/3,283; 45%), myalgia (2,498/5,192; 48%), headache (2,165/4,722; 46%), and diarrhea (337/2,622; 13%). 36/14,335 (0.3%) of infected cases developed neurologic sequelae, of which 75% were Guillain-Barré Syndrome (GBS). Several subjects reported recovery from peak of neurological complications, though some endured chronic disability. Mortality was rare (0.1%) and hospitalization (11%) was often associated with co-morbidities or GBS.<h4>Conclusions</h4>The ZIKV literature in adults was predominantly from the Americas. The most common systemic symptoms were exanthema, fever, arthralgia, and conjunctivitis; GBS was the most prevalent neurological complication. Future ZIKV studies are warranted with standardization of testing and case definitions, consistent co-infection testing, reporting of laboratory abnormalities, separation of adult and pediatric outcomes, and assessing for causation between ZIKV and neurological sequelae.Sheliza HalaniPanashe E TombindoRyan O'ReillyRafael N MirandaLaura K ErdmanClare WhiteheadJoanna M BieleckiLauren RamsayRaphael XimenesJustin BoyleCarsten KruegerShannon WillmottShaun K MorrisKellie E MurphyBeate SanderPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009516 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Sheliza Halani Panashe E Tombindo Ryan O'Reilly Rafael N Miranda Laura K Erdman Clare Whitehead Joanna M Bielecki Lauren Ramsay Raphael Ximenes Justin Boyle Carsten Krueger Shannon Willmott Shaun K Morris Kellie E Murphy Beate Sander Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review.
description	<h4>Background</h4>Zika virus (ZIKV) has generated global interest in the last five years mostly due to its resurgence in the Americas between 2015 and 2016. It was previously thought to be a self-limiting infection causing febrile illness in less than one quarter of those infected. However, a rise in birth defects amongst children born to infected pregnant women, as well as increases in neurological manifestations in adults has been demonstrated. We systemically reviewed the literature to understand clinical manifestations and health outcomes in adults globally.<h4>Methods</h4>This review was registered prospectively with PROPSERO (CRD 42018096558). We systematically searched for studies in six databases from inception to the end of September 2020. There were no language restrictions. Critical appraisal was completed using the Joanna Briggs Institute Critical Appraisal Tools.<h4>Findings</h4>We identified 73 studies globally that reported clinical outcomes in ZIKV-infected adults, of which 55 studies were from the Americas. For further analysis, we considered studies that met 70% of critical appraisal criteria and described subjects with confirmed ZIKV. The most common symptoms included: exanthema (5,456/6,129; 89%), arthralgia (3,809/6,093; 63%), fever (3,787/6,124; 62%), conjunctivitis (2,738/3,283; 45%), myalgia (2,498/5,192; 48%), headache (2,165/4,722; 46%), and diarrhea (337/2,622; 13%). 36/14,335 (0.3%) of infected cases developed neurologic sequelae, of which 75% were Guillain-Barré Syndrome (GBS). Several subjects reported recovery from peak of neurological complications, though some endured chronic disability. Mortality was rare (0.1%) and hospitalization (11%) was often associated with co-morbidities or GBS.<h4>Conclusions</h4>The ZIKV literature in adults was predominantly from the Americas. The most common systemic symptoms were exanthema, fever, arthralgia, and conjunctivitis; GBS was the most prevalent neurological complication. Future ZIKV studies are warranted with standardization of testing and case definitions, consistent co-infection testing, reporting of laboratory abnormalities, separation of adult and pediatric outcomes, and assessing for causation between ZIKV and neurological sequelae.
format	article
author	Sheliza Halani Panashe E Tombindo Ryan O'Reilly Rafael N Miranda Laura K Erdman Clare Whitehead Joanna M Bielecki Lauren Ramsay Raphael Ximenes Justin Boyle Carsten Krueger Shannon Willmott Shaun K Morris Kellie E Murphy Beate Sander
author_facet	Sheliza Halani Panashe E Tombindo Ryan O'Reilly Rafael N Miranda Laura K Erdman Clare Whitehead Joanna M Bielecki Lauren Ramsay Raphael Ximenes Justin Boyle Carsten Krueger Shannon Willmott Shaun K Morris Kellie E Murphy Beate Sander
author_sort	Sheliza Halani
title	Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review.
title_short	Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review.
title_full	Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review.
title_fullStr	Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review.
title_full_unstemmed	Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review.
title_sort	clinical manifestations and health outcomes associated with zika virus infections in adults: a systematic review.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0abe5e62ad22415c8d5b812135c2e174
work_keys_str_mv	AT shelizahalani clinicalmanifestationsandhealthoutcomesassociatedwithzikavirusinfectionsinadultsasystematicreview AT panasheetombindo clinicalmanifestationsandhealthoutcomesassociatedwithzikavirusinfectionsinadultsasystematicreview AT ryanoreilly clinicalmanifestationsandhealthoutcomesassociatedwithzikavirusinfectionsinadultsasystematicreview AT rafaelnmiranda clinicalmanifestationsandhealthoutcomesassociatedwithzikavirusinfectionsinadultsasystematicreview AT laurakerdman clinicalmanifestationsandhealthoutcomesassociatedwithzikavirusinfectionsinadultsasystematicreview AT clarewhitehead clinicalmanifestationsandhealthoutcomesassociatedwithzikavirusinfectionsinadultsasystematicreview AT joannambielecki clinicalmanifestationsandhealthoutcomesassociatedwithzikavirusinfectionsinadultsasystematicreview AT laurenramsay clinicalmanifestationsandhealthoutcomesassociatedwithzikavirusinfectionsinadultsasystematicreview AT raphaelximenes clinicalmanifestationsandhealthoutcomesassociatedwithzikavirusinfectionsinadultsasystematicreview AT justinboyle clinicalmanifestationsandhealthoutcomesassociatedwithzikavirusinfectionsinadultsasystematicreview AT carstenkrueger clinicalmanifestationsandhealthoutcomesassociatedwithzikavirusinfectionsinadultsasystematicreview AT shannonwillmott clinicalmanifestationsandhealthoutcomesassociatedwithzikavirusinfectionsinadultsasystematicreview AT shaunkmorris clinicalmanifestationsandhealthoutcomesassociatedwithzikavirusinfectionsinadultsasystematicreview AT kellieemurphy clinicalmanifestationsandhealthoutcomesassociatedwithzikavirusinfectionsinadultsasystematicreview AT beatesander clinicalmanifestationsandhealthoutcomesassociatedwithzikavirusinfectionsinadultsasystematicreview
_version_	1718413601254932480

Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review.

Ejemplares similares