Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications

Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer. Here, the authors show MPM is heterogeneously composed of epithelioid and sarcomatoid components and their proportions associate with prognosis and could inform therapeutic strategies.

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Autores principales:	Yuna Blum, Clément Meiller, Lisa Quetel, Nabila Elarouci, Mira Ayadi, Danisa Tashtanbaeva, Lucile Armenoult, François Montagne, Robin Tranchant, Annie Renier, Leanne de Koning, Marie-Christine Copin, Paul Hofman, Véronique Hofman, Henri Porte, Françoise Le Pimpec-Barthes, Jessica Zucman-Rossi, Marie-Claude Jaurand, Aurélien de Reyniès, Didier Jean
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0ac32d4c53d047abb1647a0e54445ec9
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spelling	oai:doaj.org-article:0ac32d4c53d047abb1647a0e54445ec92021-12-02T16:57:42ZDissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications10.1038/s41467-019-09307-62041-1723https://doaj.org/article/0ac32d4c53d047abb1647a0e54445ec92019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09307-6https://doaj.org/toc/2041-1723Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer. Here, the authors show MPM is heterogeneously composed of epithelioid and sarcomatoid components and their proportions associate with prognosis and could inform therapeutic strategies.Yuna BlumClément MeillerLisa QuetelNabila ElarouciMira AyadiDanisa TashtanbaevaLucile ArmenoultFrançois MontagneRobin TranchantAnnie RenierLeanne de KoningMarie-Christine CopinPaul HofmanVéronique HofmanHenri PorteFrançoise Le Pimpec-BarthesJessica Zucman-RossiMarie-Claude JaurandAurélien de ReynièsDidier JeanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuna Blum Clément Meiller Lisa Quetel Nabila Elarouci Mira Ayadi Danisa Tashtanbaeva Lucile Armenoult François Montagne Robin Tranchant Annie Renier Leanne de Koning Marie-Christine Copin Paul Hofman Véronique Hofman Henri Porte Françoise Le Pimpec-Barthes Jessica Zucman-Rossi Marie-Claude Jaurand Aurélien de Reyniès Didier Jean Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications
description	Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer. Here, the authors show MPM is heterogeneously composed of epithelioid and sarcomatoid components and their proportions associate with prognosis and could inform therapeutic strategies.
format	article
author	Yuna Blum Clément Meiller Lisa Quetel Nabila Elarouci Mira Ayadi Danisa Tashtanbaeva Lucile Armenoult François Montagne Robin Tranchant Annie Renier Leanne de Koning Marie-Christine Copin Paul Hofman Véronique Hofman Henri Porte Françoise Le Pimpec-Barthes Jessica Zucman-Rossi Marie-Claude Jaurand Aurélien de Reyniès Didier Jean
author_facet	Yuna Blum Clément Meiller Lisa Quetel Nabila Elarouci Mira Ayadi Danisa Tashtanbaeva Lucile Armenoult François Montagne Robin Tranchant Annie Renier Leanne de Koning Marie-Christine Copin Paul Hofman Véronique Hofman Henri Porte Françoise Le Pimpec-Barthes Jessica Zucman-Rossi Marie-Claude Jaurand Aurélien de Reyniès Didier Jean
author_sort	Yuna Blum
title	Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications
title_short	Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications
title_full	Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications
title_fullStr	Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications
title_full_unstemmed	Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications
title_sort	dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0ac32d4c53d047abb1647a0e54445ec9
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Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications

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