Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations
Here, the authors report that specific monoclonal antibodies isolated from vaccinated rhesus macaques can neutralize a subset of Tier 2 difficult-to-neutralize HIV-1 that express Env in an open conformation, suggesting that V3 loop-specific targeting can bias the estimation of vaccine-induced bnAbs.
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Nature Portfolio
2019
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oai:doaj.org-article:0ac5be9185814e708e45b16386f135cf2021-12-02T15:36:23ZDifficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations10.1038/s41467-019-10899-22041-1723https://doaj.org/article/0ac5be9185814e708e45b16386f135cf2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10899-2https://doaj.org/toc/2041-1723Here, the authors report that specific monoclonal antibodies isolated from vaccinated rhesus macaques can neutralize a subset of Tier 2 difficult-to-neutralize HIV-1 that express Env in an open conformation, suggesting that V3 loop-specific targeting can bias the estimation of vaccine-induced bnAbs.Qifeng HanJulia A. JonesNathan I. NicelyRachel K. ReedXiaoying ShenKatayoun MansouriMark LouderAshley M. TramaS. Munir AlamRobert J. EdwardsMattia BonsignoriGeorgia D. TomarasBette KorberDavid C. MontefioriJohn R. MascolaMichael S. SeamanBarton F. HaynesKevin O. SaundersNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Qifeng Han Julia A. Jones Nathan I. Nicely Rachel K. Reed Xiaoying Shen Katayoun Mansouri Mark Louder Ashley M. Trama S. Munir Alam Robert J. Edwards Mattia Bonsignori Georgia D. Tomaras Bette Korber David C. Montefiori John R. Mascola Michael S. Seaman Barton F. Haynes Kevin O. Saunders Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations |
| description |
Here, the authors report that specific monoclonal antibodies isolated from vaccinated rhesus macaques can neutralize a subset of Tier 2 difficult-to-neutralize HIV-1 that express Env in an open conformation, suggesting that V3 loop-specific targeting can bias the estimation of vaccine-induced bnAbs. |
| format |
article |
| author |
Qifeng Han Julia A. Jones Nathan I. Nicely Rachel K. Reed Xiaoying Shen Katayoun Mansouri Mark Louder Ashley M. Trama S. Munir Alam Robert J. Edwards Mattia Bonsignori Georgia D. Tomaras Bette Korber David C. Montefiori John R. Mascola Michael S. Seaman Barton F. Haynes Kevin O. Saunders |
| author_facet |
Qifeng Han Julia A. Jones Nathan I. Nicely Rachel K. Reed Xiaoying Shen Katayoun Mansouri Mark Louder Ashley M. Trama S. Munir Alam Robert J. Edwards Mattia Bonsignori Georgia D. Tomaras Bette Korber David C. Montefiori John R. Mascola Michael S. Seaman Barton F. Haynes Kevin O. Saunders |
| author_sort |
Qifeng Han |
| title |
Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations |
| title_short |
Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations |
| title_full |
Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations |
| title_fullStr |
Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations |
| title_full_unstemmed |
Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations |
| title_sort |
difficult-to-neutralize global hiv-1 isolates are neutralized by antibodies targeting open envelope conformations |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/0ac5be9185814e708e45b16386f135cf |
| work_keys_str_mv |
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