Perspectives on Assembling Coronavirus Spikes on Fiber Optics to Reveal Broadly Recognizing Antibodies and Generate a Universal Coronavirus Detector

In time of COVID-19 biological detection technologies are of crucial relevance. We propose here the use of state of the art optical fiber biosensors to address two aspects of the fight against SARS-CoV-2 and other pandemic human coronaviruses (HCoVs). Fiber optic biosensors functionalized with HCoV...

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Autores principales:	Marzhan Sypabekova, Daniele Tosi, Luca Vangelista
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	COVID-19 coronavirus spike broadly neutralizing antibodies biosensor optical fiber Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/0ac5d7a8f5b04ea3aadbe567411c3092
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spelling	oai:doaj.org-article:0ac5d7a8f5b04ea3aadbe567411c30922021-12-01T06:53:02ZPerspectives on Assembling Coronavirus Spikes on Fiber Optics to Reveal Broadly Recognizing Antibodies and Generate a Universal Coronavirus Detector2296-418510.3389/fbioe.2021.637715https://doaj.org/article/0ac5d7a8f5b04ea3aadbe567411c30922021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.637715/fullhttps://doaj.org/toc/2296-4185In time of COVID-19 biological detection technologies are of crucial relevance. We propose here the use of state of the art optical fiber biosensors to address two aspects of the fight against SARS-CoV-2 and other pandemic human coronaviruses (HCoVs). Fiber optic biosensors functionalized with HCoV spikes could be used to discover broadly neutralizing antibodies (bnAbs) effective against known HCoVs (SARS-CoV, MERS-CoV and SARS-CoV-2) and likely future ones. In turn, identified bnAbs, once immobilized onto fiber optic biosensors, should be capable to detect HCoVs as diagnostic and environmental sensing devices. The therapeutic and preventative value of bnAbs is immense as they can be used for passive immunization and for the educated development of a universal vaccine (active immunization). Hence, HCoV bnAbs represent an extremely important resource for future preparedness against coronavirus-borne pandemics. Furthermore, the assembly of bnAb-based biosensors constitutes an innovative approach to counteract public health threats, as it bears diagnostic competence additional to environmental detection of a range of pandemic strains. This concept can be extended to different pandemic viruses, as well as bio-warfare threats that entail existing, emerging and extinct viruses (e.g., the smallpox-causing Variola virus). We report here the forefront fiber optic biosensor technology that could be implemented to achieve these aims.Marzhan SypabekovaDaniele TosiDaniele TosiLuca VangelistaFrontiers Media S.A.articleCOVID-19coronavirusspikebroadly neutralizing antibodiesbiosensoroptical fiberBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 coronavirus spike broadly neutralizing antibodies biosensor optical fiber Biotechnology TP248.13-248.65
spellingShingle	COVID-19 coronavirus spike broadly neutralizing antibodies biosensor optical fiber Biotechnology TP248.13-248.65 Marzhan Sypabekova Daniele Tosi Daniele Tosi Luca Vangelista Perspectives on Assembling Coronavirus Spikes on Fiber Optics to Reveal Broadly Recognizing Antibodies and Generate a Universal Coronavirus Detector
description	In time of COVID-19 biological detection technologies are of crucial relevance. We propose here the use of state of the art optical fiber biosensors to address two aspects of the fight against SARS-CoV-2 and other pandemic human coronaviruses (HCoVs). Fiber optic biosensors functionalized with HCoV spikes could be used to discover broadly neutralizing antibodies (bnAbs) effective against known HCoVs (SARS-CoV, MERS-CoV and SARS-CoV-2) and likely future ones. In turn, identified bnAbs, once immobilized onto fiber optic biosensors, should be capable to detect HCoVs as diagnostic and environmental sensing devices. The therapeutic and preventative value of bnAbs is immense as they can be used for passive immunization and for the educated development of a universal vaccine (active immunization). Hence, HCoV bnAbs represent an extremely important resource for future preparedness against coronavirus-borne pandemics. Furthermore, the assembly of bnAb-based biosensors constitutes an innovative approach to counteract public health threats, as it bears diagnostic competence additional to environmental detection of a range of pandemic strains. This concept can be extended to different pandemic viruses, as well as bio-warfare threats that entail existing, emerging and extinct viruses (e.g., the smallpox-causing Variola virus). We report here the forefront fiber optic biosensor technology that could be implemented to achieve these aims.
format	article
author	Marzhan Sypabekova Daniele Tosi Daniele Tosi Luca Vangelista
author_facet	Marzhan Sypabekova Daniele Tosi Daniele Tosi Luca Vangelista
author_sort	Marzhan Sypabekova
title	Perspectives on Assembling Coronavirus Spikes on Fiber Optics to Reveal Broadly Recognizing Antibodies and Generate a Universal Coronavirus Detector
title_short	Perspectives on Assembling Coronavirus Spikes on Fiber Optics to Reveal Broadly Recognizing Antibodies and Generate a Universal Coronavirus Detector
title_full	Perspectives on Assembling Coronavirus Spikes on Fiber Optics to Reveal Broadly Recognizing Antibodies and Generate a Universal Coronavirus Detector
title_fullStr	Perspectives on Assembling Coronavirus Spikes on Fiber Optics to Reveal Broadly Recognizing Antibodies and Generate a Universal Coronavirus Detector
title_full_unstemmed	Perspectives on Assembling Coronavirus Spikes on Fiber Optics to Reveal Broadly Recognizing Antibodies and Generate a Universal Coronavirus Detector
title_sort	perspectives on assembling coronavirus spikes on fiber optics to reveal broadly recognizing antibodies and generate a universal coronavirus detector
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/0ac5d7a8f5b04ea3aadbe567411c3092
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Perspectives on Assembling Coronavirus Spikes on Fiber Optics to Reveal Broadly Recognizing Antibodies and Generate a Universal Coronavirus Detector

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