Estrogen mediates innate and adaptive immune alterations to influenza infection in pregnant mice.

Pregnancy is a leading risk factor for severe complications during an influenza virus infection. Women infected during their second and third trimesters are at increased risk for severe cardiopulmonary complications, premature delivery, and death. Here, we establish a murine model of aerosolized inf...

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Autores principales:	Michael A Pazos, Thomas A Kraus, César Muñoz-Fontela, Thomas M Moran
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0ac8d58bc0774108907e53b6e50f30be
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spelling	oai:doaj.org-article:0ac8d58bc0774108907e53b6e50f30be2021-11-18T07:13:19ZEstrogen mediates innate and adaptive immune alterations to influenza infection in pregnant mice.1932-620310.1371/journal.pone.0040502https://doaj.org/article/0ac8d58bc0774108907e53b6e50f30be2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22792357/?tool=EBIhttps://doaj.org/toc/1932-6203Pregnancy is a leading risk factor for severe complications during an influenza virus infection. Women infected during their second and third trimesters are at increased risk for severe cardiopulmonary complications, premature delivery, and death. Here, we establish a murine model of aerosolized influenza infection during pregnancy. We find significantly altered innate antiviral responses in pregnant mice, including decreased levels of IFN-β, IL-1α, and IFN-γ at early time points of infection. We also find reduced cytotoxic T cell activity and delayed viral clearance. We further demonstrate that pregnancy levels of the estrogen 17-β-estradiol are able to induce key anti-inflammatory phenotypes in immune responses to the virus independently of other hormones or pregnancy-related stressors. We conclude that elevated estrogen levels result in an attenuated anti-viral immune response, and that pregnancy-associated morbidities occur in the context of this anti-inflammatory phenotype.Michael A PazosThomas A KrausCésar Muñoz-FontelaThomas M MoranPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e40502 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael A Pazos Thomas A Kraus César Muñoz-Fontela Thomas M Moran Estrogen mediates innate and adaptive immune alterations to influenza infection in pregnant mice.
description	Pregnancy is a leading risk factor for severe complications during an influenza virus infection. Women infected during their second and third trimesters are at increased risk for severe cardiopulmonary complications, premature delivery, and death. Here, we establish a murine model of aerosolized influenza infection during pregnancy. We find significantly altered innate antiviral responses in pregnant mice, including decreased levels of IFN-β, IL-1α, and IFN-γ at early time points of infection. We also find reduced cytotoxic T cell activity and delayed viral clearance. We further demonstrate that pregnancy levels of the estrogen 17-β-estradiol are able to induce key anti-inflammatory phenotypes in immune responses to the virus independently of other hormones or pregnancy-related stressors. We conclude that elevated estrogen levels result in an attenuated anti-viral immune response, and that pregnancy-associated morbidities occur in the context of this anti-inflammatory phenotype.
format	article
author	Michael A Pazos Thomas A Kraus César Muñoz-Fontela Thomas M Moran
author_facet	Michael A Pazos Thomas A Kraus César Muñoz-Fontela Thomas M Moran
author_sort	Michael A Pazos
title	Estrogen mediates innate and adaptive immune alterations to influenza infection in pregnant mice.
title_short	Estrogen mediates innate and adaptive immune alterations to influenza infection in pregnant mice.
title_full	Estrogen mediates innate and adaptive immune alterations to influenza infection in pregnant mice.
title_fullStr	Estrogen mediates innate and adaptive immune alterations to influenza infection in pregnant mice.
title_full_unstemmed	Estrogen mediates innate and adaptive immune alterations to influenza infection in pregnant mice.
title_sort	estrogen mediates innate and adaptive immune alterations to influenza infection in pregnant mice.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/0ac8d58bc0774108907e53b6e50f30be
work_keys_str_mv	AT michaelapazos estrogenmediatesinnateandadaptiveimmunealterationstoinfluenzainfectioninpregnantmice AT thomasakraus estrogenmediatesinnateandadaptiveimmunealterationstoinfluenzainfectioninpregnantmice AT cesarmunozfontela estrogenmediatesinnateandadaptiveimmunealterationstoinfluenzainfectioninpregnantmice AT thomasmmoran estrogenmediatesinnateandadaptiveimmunealterationstoinfluenzainfectioninpregnantmice
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Estrogen mediates innate and adaptive immune alterations to influenza infection in pregnant mice.

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