Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility
Ewing sarcoma (EWS) is a rare pediatric bone cancer typically involving the EWSR1-FLI1 fusion. Here the authors perform a genome-wide association study and report three new EWS risk loci that reside near GGAA repeat sequences, and identify candidate genes (RREB1 and KIZ) from eQTL analysis.
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Nature Portfolio
2018
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oai:doaj.org-article:0ac8edbb89d948f498acb3404c1156e82021-12-02T15:34:48ZGenome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility10.1038/s41467-018-05537-22041-1723https://doaj.org/article/0ac8edbb89d948f498acb3404c1156e82018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05537-2https://doaj.org/toc/2041-1723Ewing sarcoma (EWS) is a rare pediatric bone cancer typically involving the EWSR1-FLI1 fusion. Here the authors perform a genome-wide association study and report three new EWS risk loci that reside near GGAA repeat sequences, and identify candidate genes (RREB1 and KIZ) from eQTL analysis.Mitchell J. MachielaThomas G. P. GrünewaldDidier SurdezStephanie ReynaudOlivier MirabeauEric KarlinsRebeca Alba RubioSakina ZaidiSandrine Grossetete-LalamiStelly BalletEve LapoubleValérie LaurenceJean MichonGaelle PierronHeinrich KovarNathalie GasparUdo KontnyAnna González-NeiraPiero PicciJavier AlonsoAna Patino-GarciaNadège CorradiniPerrine Marec BérardNeal D. FreedmanNathaniel RothmanCasey L. DagnallLaurie BurdettKristine JonesMichelle ManningKathleen WyattWeiyin ZhouMeredith YeagerDavid G. CoxRobert N. HooverJaved KhanGregory T. ArmstrongWendy M. LeisenringSmita BhatiaLeslie L. RobisonAndreas E. KulozikJennifer KriebelThomas MeitingerMarkus MetzlerWolfgang HartmannKonstantin StrauchThomas KirchnerUta DirksenLindsay M. MortonLisa MirabelloMargaret A. TuckerFranck TirodeStephen J. ChanockOlivier DelattreNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Mitchell J. Machiela Thomas G. P. Grünewald Didier Surdez Stephanie Reynaud Olivier Mirabeau Eric Karlins Rebeca Alba Rubio Sakina Zaidi Sandrine Grossetete-Lalami Stelly Ballet Eve Lapouble Valérie Laurence Jean Michon Gaelle Pierron Heinrich Kovar Nathalie Gaspar Udo Kontny Anna González-Neira Piero Picci Javier Alonso Ana Patino-Garcia Nadège Corradini Perrine Marec Bérard Neal D. Freedman Nathaniel Rothman Casey L. Dagnall Laurie Burdett Kristine Jones Michelle Manning Kathleen Wyatt Weiyin Zhou Meredith Yeager David G. Cox Robert N. Hoover Javed Khan Gregory T. Armstrong Wendy M. Leisenring Smita Bhatia Leslie L. Robison Andreas E. Kulozik Jennifer Kriebel Thomas Meitinger Markus Metzler Wolfgang Hartmann Konstantin Strauch Thomas Kirchner Uta Dirksen Lindsay M. Morton Lisa Mirabello Margaret A. Tucker Franck Tirode Stephen J. Chanock Olivier Delattre Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility |
| description |
Ewing sarcoma (EWS) is a rare pediatric bone cancer typically involving the EWSR1-FLI1 fusion. Here the authors perform a genome-wide association study and report three new EWS risk loci that reside near GGAA repeat sequences, and identify candidate genes (RREB1 and KIZ) from eQTL analysis. |
| format |
article |
| author |
Mitchell J. Machiela Thomas G. P. Grünewald Didier Surdez Stephanie Reynaud Olivier Mirabeau Eric Karlins Rebeca Alba Rubio Sakina Zaidi Sandrine Grossetete-Lalami Stelly Ballet Eve Lapouble Valérie Laurence Jean Michon Gaelle Pierron Heinrich Kovar Nathalie Gaspar Udo Kontny Anna González-Neira Piero Picci Javier Alonso Ana Patino-Garcia Nadège Corradini Perrine Marec Bérard Neal D. Freedman Nathaniel Rothman Casey L. Dagnall Laurie Burdett Kristine Jones Michelle Manning Kathleen Wyatt Weiyin Zhou Meredith Yeager David G. Cox Robert N. Hoover Javed Khan Gregory T. Armstrong Wendy M. Leisenring Smita Bhatia Leslie L. Robison Andreas E. Kulozik Jennifer Kriebel Thomas Meitinger Markus Metzler Wolfgang Hartmann Konstantin Strauch Thomas Kirchner Uta Dirksen Lindsay M. Morton Lisa Mirabello Margaret A. Tucker Franck Tirode Stephen J. Chanock Olivier Delattre |
| author_facet |
Mitchell J. Machiela Thomas G. P. Grünewald Didier Surdez Stephanie Reynaud Olivier Mirabeau Eric Karlins Rebeca Alba Rubio Sakina Zaidi Sandrine Grossetete-Lalami Stelly Ballet Eve Lapouble Valérie Laurence Jean Michon Gaelle Pierron Heinrich Kovar Nathalie Gaspar Udo Kontny Anna González-Neira Piero Picci Javier Alonso Ana Patino-Garcia Nadège Corradini Perrine Marec Bérard Neal D. Freedman Nathaniel Rothman Casey L. Dagnall Laurie Burdett Kristine Jones Michelle Manning Kathleen Wyatt Weiyin Zhou Meredith Yeager David G. Cox Robert N. Hoover Javed Khan Gregory T. Armstrong Wendy M. Leisenring Smita Bhatia Leslie L. Robison Andreas E. Kulozik Jennifer Kriebel Thomas Meitinger Markus Metzler Wolfgang Hartmann Konstantin Strauch Thomas Kirchner Uta Dirksen Lindsay M. Morton Lisa Mirabello Margaret A. Tucker Franck Tirode Stephen J. Chanock Olivier Delattre |
| author_sort |
Mitchell J. Machiela |
| title |
Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility |
| title_short |
Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility |
| title_full |
Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility |
| title_fullStr |
Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility |
| title_full_unstemmed |
Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility |
| title_sort |
genome-wide association study identifies multiple new loci associated with ewing sarcoma susceptibility |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/0ac8edbb89d948f498acb3404c1156e8 |
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