Update on the diagnosis and management of Behçet’s disease
Ryo Rokutanda, Mitsumasa Kishimoto, Masato Okada Immuno-Rheumatology Center, St Luke’s International Hospital, Tokyo, Japan Abstract: Behçet’s disease is a multi-organ disorder that is more common in countries around the Silk Road, and manifests as mucosal ulcers and...
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Dove Medical Press
2014
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oai:doaj.org-article:0ad0ae7ebe8e41d5a58e90469a4914ed2021-12-02T05:01:40ZUpdate on the diagnosis and management of Behçet’s disease1179-156Xhttps://doaj.org/article/0ad0ae7ebe8e41d5a58e90469a4914ed2014-12-01T00:00:00Zhttp://www.dovepress.com/update-on-the-diagnosis-and-management-of-behccediletrsquos-disease-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156X Ryo Rokutanda, Mitsumasa Kishimoto, Masato Okada Immuno-Rheumatology Center, St Luke’s International Hospital, Tokyo, Japan Abstract: Behçet’s disease is a multi-organ disorder that is more common in countries around the Silk Road, and manifests as mucosal ulcers and skin lesions, and with ocular involvement. As a systemic disease, it can also involve gastrointestinal organs and the central nervous or cardiovascular systems. Although the etiology of Behçet's disease is not clearly identified, the pathogenesis of the disease is most commonly hypothesized as a profound inflammatory response triggered by an infectious agent in a genetically susceptible host. As there are no single specific manifestations or specific diagnostic tests, various diagnostic criteria have been proposed around the world, and, among them, the International Study Group criteria have been most commonly used. As the clinical expression of Behçet's disease is heterogeneous, the treatment should be individualized based on involved organs, severity of the disease, and patient's background. The choice of therapeutic agents is limited by lack of clinical trials and is based largely on case reports, case series, and several open-label clinical trials. Corticosteroids, colchicine, and traditional immunosuppressive agents, including azathioprine and cyclosporine, have been used for the treatment of Behçet’s disease. Recently, tumor necrosis factor (TNF) inhibitors have become available for several rheumatic diseases, and considerable published data suggest that TNF inhibitors represent an important therapeutic advance for patients with severe and resistant disease, as well as for those with contraindications or intolerance to these treatments. Keywords: Behçet’s disease, therapeutic agents, etiology, diagnosisRokutanda RKishimoto MOkada MDove Medical PressarticleDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol 2015, Iss default, Pp 1-8 (2014) |
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DOAJ |
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DOAJ |
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EN |
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Diseases of the musculoskeletal system RC925-935 |
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Diseases of the musculoskeletal system RC925-935 Rokutanda R Kishimoto M Okada M Update on the diagnosis and management of Behçet’s disease |
| description |
Ryo Rokutanda, Mitsumasa Kishimoto, Masato Okada Immuno-Rheumatology Center, St Luke’s International Hospital, Tokyo, Japan Abstract: Behçet’s disease is a multi-organ disorder that is more common in countries around the Silk Road, and manifests as mucosal ulcers and skin lesions, and with ocular involvement. As a systemic disease, it can also involve gastrointestinal organs and the central nervous or cardiovascular systems. Although the etiology of Behçet's disease is not clearly identified, the pathogenesis of the disease is most commonly hypothesized as a profound inflammatory response triggered by an infectious agent in a genetically susceptible host. As there are no single specific manifestations or specific diagnostic tests, various diagnostic criteria have been proposed around the world, and, among them, the International Study Group criteria have been most commonly used. As the clinical expression of Behçet's disease is heterogeneous, the treatment should be individualized based on involved organs, severity of the disease, and patient's background. The choice of therapeutic agents is limited by lack of clinical trials and is based largely on case reports, case series, and several open-label clinical trials. Corticosteroids, colchicine, and traditional immunosuppressive agents, including azathioprine and cyclosporine, have been used for the treatment of Behçet’s disease. Recently, tumor necrosis factor (TNF) inhibitors have become available for several rheumatic diseases, and considerable published data suggest that TNF inhibitors represent an important therapeutic advance for patients with severe and resistant disease, as well as for those with contraindications or intolerance to these treatments. Keywords: Behçet’s disease, therapeutic agents, etiology, diagnosis |
| format |
article |
| author |
Rokutanda R Kishimoto M Okada M |
| author_facet |
Rokutanda R Kishimoto M Okada M |
| author_sort |
Rokutanda R |
| title |
Update on the diagnosis and management of Behçet’s disease |
| title_short |
Update on the diagnosis and management of Behçet’s disease |
| title_full |
Update on the diagnosis and management of Behçet’s disease |
| title_fullStr |
Update on the diagnosis and management of Behçet’s disease |
| title_full_unstemmed |
Update on the diagnosis and management of Behçet’s disease |
| title_sort |
update on the diagnosis and management of behçet’s disease |
| publisher |
Dove Medical Press |
| publishDate |
2014 |
| url |
https://doaj.org/article/0ad0ae7ebe8e41d5a58e90469a4914ed |
| work_keys_str_mv |
AT rokutandar updateonthediagnosisandmanagementofbehccediletrsquosdisease AT kishimotom updateonthediagnosisandmanagementofbehccediletrsquosdisease AT okadam updateonthediagnosisandmanagementofbehccediletrsquosdisease |
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