TCF21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice

TCF21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice

Whether the adult testis harbours a somatic progenitor population is unknown. Here, the authors provide evidence that the testis interstitial cells expressing the transcription factor Tcf21 maintain adult testis homeostasis during aging, and act as potential reserve somatic progenitors following inj...

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Autores principales: Yu-chi Shen, Adrienne Niederriter Shami, Lindsay Moritz, Hailey Larose, Gabriel L. Manske, Qianyi Ma, Xianing Zheng, Meena Sukhwani, Michael Czerwinski, Caleb Sultan, Haolin Chen, Stephen J. Gurczynski, Jason R. Spence, Kyle E. Orwig, Michelle Tallquist, Jun Z. Li, Saher Sue Hammoud
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/0ad48386d6e94016bc9c108c31f26ee9
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spelling oai:doaj.org-article:0ad48386d6e94016bc9c108c31f26ee92021-12-02T17:45:15ZTCF21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice10.1038/s41467-021-24130-82041-1723https://doaj.org/article/0ad48386d6e94016bc9c108c31f26ee92021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24130-8https://doaj.org/toc/2041-1723Whether the adult testis harbours a somatic progenitor population is unknown. Here, the authors provide evidence that the testis interstitial cells expressing the transcription factor Tcf21 maintain adult testis homeostasis during aging, and act as potential reserve somatic progenitors following injury.Yu-chi ShenAdrienne Niederriter ShamiLindsay MoritzHailey LaroseGabriel L. ManskeQianyi MaXianing ZhengMeena SukhwaniMichael CzerwinskiCaleb SultanHaolin ChenStephen J. GurczynskiJason R. SpenceKyle E. OrwigMichelle TallquistJun Z. LiSaher Sue HammoudNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yu-chi Shen
Adrienne Niederriter Shami
Lindsay Moritz
Hailey Larose
Gabriel L. Manske
Qianyi Ma
Xianing Zheng
Meena Sukhwani
Michael Czerwinski
Caleb Sultan
Haolin Chen
Stephen J. Gurczynski
Jason R. Spence
Kyle E. Orwig
Michelle Tallquist
Jun Z. Li
Saher Sue Hammoud
TCF21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice
description Whether the adult testis harbours a somatic progenitor population is unknown. Here, the authors provide evidence that the testis interstitial cells expressing the transcription factor Tcf21 maintain adult testis homeostasis during aging, and act as potential reserve somatic progenitors following injury.
format article
author Yu-chi Shen
Adrienne Niederriter Shami
Lindsay Moritz
Hailey Larose
Gabriel L. Manske
Qianyi Ma
Xianing Zheng
Meena Sukhwani
Michael Czerwinski
Caleb Sultan
Haolin Chen
Stephen J. Gurczynski
Jason R. Spence
Kyle E. Orwig
Michelle Tallquist
Jun Z. Li
Saher Sue Hammoud
author_facet Yu-chi Shen
Adrienne Niederriter Shami
Lindsay Moritz
Hailey Larose
Gabriel L. Manske
Qianyi Ma
Xianing Zheng
Meena Sukhwani
Michael Czerwinski
Caleb Sultan
Haolin Chen
Stephen J. Gurczynski
Jason R. Spence
Kyle E. Orwig
Michelle Tallquist
Jun Z. Li
Saher Sue Hammoud
author_sort Yu-chi Shen
title TCF21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice
title_short TCF21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice
title_full TCF21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice
title_fullStr TCF21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice
title_full_unstemmed TCF21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice
title_sort tcf21+ mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/0ad48386d6e94016bc9c108c31f26ee9
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