Transforming growth factor β plays an important role in enhancing wound healing by topical application of Povidone-iodine

Abstract Povidone-iodine (PVI) is principally used as an antimicrobial agent. It has been found that 0.5% PVI can attenuate congestion, edema and pain induced by pressure sores. Thus this study aimed to assess the effects of 0.5% PVI on acute skin wounds. Four full-thickness excisional wounds were g...

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Autores principales:	Li Wang, Wenhan Qin, Yaying Zhou, Bin Chen, Xiaoqing Zhao, Hailin Zhao, Emma Mi, Ella Mi, Qingmei Wang, Jiaolin Ning
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0ad9d75e7d6642a183df9bea82d6fdad
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spelling	oai:doaj.org-article:0ad9d75e7d6642a183df9bea82d6fdad2021-12-02T15:06:23ZTransforming growth factor β plays an important role in enhancing wound healing by topical application of Povidone-iodine10.1038/s41598-017-01116-52045-2322https://doaj.org/article/0ad9d75e7d6642a183df9bea82d6fdad2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01116-5https://doaj.org/toc/2045-2322Abstract Povidone-iodine (PVI) is principally used as an antimicrobial agent. It has been found that 0.5% PVI can attenuate congestion, edema and pain induced by pressure sores. Thus this study aimed to assess the effects of 0.5% PVI on acute skin wounds. Four full-thickness excisional wounds were generated on the dorsal skin of male Sprague-Dawley rats with a 10-mm sterile punch. Two wounds were left untreated and the other two were dressed with gauze with 0.5% PVI for 1 hour per day for the first 5 days after injury. 10-mm full-thickness excisional wounds were also generated on the dorsal skin of rats treated with 10 mg/kg SB431542 and all wounds were treated with 0.5% PVI for 5 days. PVI treatment enhanced wound healing via promotion of expression of α SMA and TGF β, neovascularization and re-epithelialization. Interleukin 6 was reduced following PVI treatment. Inhibition of TGF β abolished the effect of PVI treatment on wound closure. These data show that topical application of 0.5% PVI could promote acute skin wound healing though increased expression of TGF β leading to enhanced formation of granulation tissue, even in the absence of obvious infection.Li WangWenhan QinYaying ZhouBin ChenXiaoqing ZhaoHailin ZhaoEmma MiElla MiQingmei WangJiaolin NingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Li Wang Wenhan Qin Yaying Zhou Bin Chen Xiaoqing Zhao Hailin Zhao Emma Mi Ella Mi Qingmei Wang Jiaolin Ning Transforming growth factor β plays an important role in enhancing wound healing by topical application of Povidone-iodine
description	Abstract Povidone-iodine (PVI) is principally used as an antimicrobial agent. It has been found that 0.5% PVI can attenuate congestion, edema and pain induced by pressure sores. Thus this study aimed to assess the effects of 0.5% PVI on acute skin wounds. Four full-thickness excisional wounds were generated on the dorsal skin of male Sprague-Dawley rats with a 10-mm sterile punch. Two wounds were left untreated and the other two were dressed with gauze with 0.5% PVI for 1 hour per day for the first 5 days after injury. 10-mm full-thickness excisional wounds were also generated on the dorsal skin of rats treated with 10 mg/kg SB431542 and all wounds were treated with 0.5% PVI for 5 days. PVI treatment enhanced wound healing via promotion of expression of α SMA and TGF β, neovascularization and re-epithelialization. Interleukin 6 was reduced following PVI treatment. Inhibition of TGF β abolished the effect of PVI treatment on wound closure. These data show that topical application of 0.5% PVI could promote acute skin wound healing though increased expression of TGF β leading to enhanced formation of granulation tissue, even in the absence of obvious infection.
format	article
author	Li Wang Wenhan Qin Yaying Zhou Bin Chen Xiaoqing Zhao Hailin Zhao Emma Mi Ella Mi Qingmei Wang Jiaolin Ning
author_facet	Li Wang Wenhan Qin Yaying Zhou Bin Chen Xiaoqing Zhao Hailin Zhao Emma Mi Ella Mi Qingmei Wang Jiaolin Ning
author_sort	Li Wang
title	Transforming growth factor β plays an important role in enhancing wound healing by topical application of Povidone-iodine
title_short	Transforming growth factor β plays an important role in enhancing wound healing by topical application of Povidone-iodine
title_full	Transforming growth factor β plays an important role in enhancing wound healing by topical application of Povidone-iodine
title_fullStr	Transforming growth factor β plays an important role in enhancing wound healing by topical application of Povidone-iodine
title_full_unstemmed	Transforming growth factor β plays an important role in enhancing wound healing by topical application of Povidone-iodine
title_sort	transforming growth factor β plays an important role in enhancing wound healing by topical application of povidone-iodine
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0ad9d75e7d6642a183df9bea82d6fdad
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Transforming growth factor β plays an important role in enhancing wound healing by topical application of Povidone-iodine

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