Continuous subcutaneous insulin infusion alters microRNA expression and glycaemic variability in children with type 1 diabetes

Abstract To determine whether continuous subcutaneous insulin infusion (CSII) vs. multiple daily injections (MDI) therapy from near-diagnosis of type 1 diabetes is associated with reduced glycaemic variability (GV) and altered microRNA (miRNAs) expression. Adolescents (74% male) within 3-months of d...

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Autores principales:	Emma S. Scott, Andrzej S. Januszewski, Luke M. Carroll, Gregory R. Fulcher, Mugdha V. Joglekar, Anandwardhan A. Hardikar, Timothy W. Jones, Elizabeth A. Davis, Alicia J. Jenkins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0adc48526a5746a2a86954d1d120e739
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spelling	oai:doaj.org-article:0adc48526a5746a2a86954d1d120e7392021-12-02T18:51:52ZContinuous subcutaneous insulin infusion alters microRNA expression and glycaemic variability in children with type 1 diabetes10.1038/s41598-021-95824-82045-2322https://doaj.org/article/0adc48526a5746a2a86954d1d120e7392021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95824-8https://doaj.org/toc/2045-2322Abstract To determine whether continuous subcutaneous insulin infusion (CSII) vs. multiple daily injections (MDI) therapy from near-diagnosis of type 1 diabetes is associated with reduced glycaemic variability (GV) and altered microRNA (miRNAs) expression. Adolescents (74% male) within 3-months of diabetes diagnosis (n = 27) were randomized to CSII (n = 12) or MDI. HbA1c, 1-5-Anhydroglucitol (1,5-AG), high sensitivity C-peptide and a custom TaqMan qPCR panel of 52 miRNAs were measured at baseline and follow-up (median (LQ-UQ); 535 (519–563) days). There were no significant differences between groups in baseline or follow-up HbA1c or C-peptide, nor baseline miRNAs. Mean ± SD 1,5-AG improved with CSII vs. MDI (3.1 ± 4.1 vs. − 2.2 ± − 7.0 mg/ml respectively, P = 0.029). On follow-up 11 miRNAs associated with diabetes vascular complications had altered expression in CSII-users. Early CSII vs. MDI use is associated with lower GV and less adverse vascular-related miRNAs. Relationships with future complications are of interest.Emma S. ScottAndrzej S. JanuszewskiLuke M. CarrollGregory R. FulcherMugdha V. JoglekarAnandwardhan A. HardikarTimothy W. JonesElizabeth A. DavisAlicia J. JenkinsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emma S. Scott Andrzej S. Januszewski Luke M. Carroll Gregory R. Fulcher Mugdha V. Joglekar Anandwardhan A. Hardikar Timothy W. Jones Elizabeth A. Davis Alicia J. Jenkins Continuous subcutaneous insulin infusion alters microRNA expression and glycaemic variability in children with type 1 diabetes
description	Abstract To determine whether continuous subcutaneous insulin infusion (CSII) vs. multiple daily injections (MDI) therapy from near-diagnosis of type 1 diabetes is associated with reduced glycaemic variability (GV) and altered microRNA (miRNAs) expression. Adolescents (74% male) within 3-months of diabetes diagnosis (n = 27) were randomized to CSII (n = 12) or MDI. HbA1c, 1-5-Anhydroglucitol (1,5-AG), high sensitivity C-peptide and a custom TaqMan qPCR panel of 52 miRNAs were measured at baseline and follow-up (median (LQ-UQ); 535 (519–563) days). There were no significant differences between groups in baseline or follow-up HbA1c or C-peptide, nor baseline miRNAs. Mean ± SD 1,5-AG improved with CSII vs. MDI (3.1 ± 4.1 vs. − 2.2 ± − 7.0 mg/ml respectively, P = 0.029). On follow-up 11 miRNAs associated with diabetes vascular complications had altered expression in CSII-users. Early CSII vs. MDI use is associated with lower GV and less adverse vascular-related miRNAs. Relationships with future complications are of interest.
format	article
author	Emma S. Scott Andrzej S. Januszewski Luke M. Carroll Gregory R. Fulcher Mugdha V. Joglekar Anandwardhan A. Hardikar Timothy W. Jones Elizabeth A. Davis Alicia J. Jenkins
author_facet	Emma S. Scott Andrzej S. Januszewski Luke M. Carroll Gregory R. Fulcher Mugdha V. Joglekar Anandwardhan A. Hardikar Timothy W. Jones Elizabeth A. Davis Alicia J. Jenkins
author_sort	Emma S. Scott
title	Continuous subcutaneous insulin infusion alters microRNA expression and glycaemic variability in children with type 1 diabetes
title_short	Continuous subcutaneous insulin infusion alters microRNA expression and glycaemic variability in children with type 1 diabetes
title_full	Continuous subcutaneous insulin infusion alters microRNA expression and glycaemic variability in children with type 1 diabetes
title_fullStr	Continuous subcutaneous insulin infusion alters microRNA expression and glycaemic variability in children with type 1 diabetes
title_full_unstemmed	Continuous subcutaneous insulin infusion alters microRNA expression and glycaemic variability in children with type 1 diabetes
title_sort	continuous subcutaneous insulin infusion alters microrna expression and glycaemic variability in children with type 1 diabetes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0adc48526a5746a2a86954d1d120e739
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Continuous subcutaneous insulin infusion alters microRNA expression and glycaemic variability in children with type 1 diabetes

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