A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site

The receptor-binding site (RBS) of influenza A viruses evolves to evade immune pressure, while maintaining efficient attachment to the host receptor. Wu et al. here identify the complex epistatic network in RBS of H3N2 viruses that limits reversibility of naturally occurring mutations to retain infe...

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Autores principales:	Nicholas C. Wu, Andrew J. Thompson, Jia Xie, Chih-Wei Lin, Corwin M. Nycholat, Xueyong Zhu, Richard A. Lerner, James C. Paulson, Ian A. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0ae0a838cecb4e899bae6363fc59982b
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spelling	oai:doaj.org-article:0ae0a838cecb4e899bae6363fc59982b2021-12-02T17:31:43ZA complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site10.1038/s41467-018-03663-52041-1723https://doaj.org/article/0ae0a838cecb4e899bae6363fc59982b2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03663-5https://doaj.org/toc/2041-1723The receptor-binding site (RBS) of influenza A viruses evolves to evade immune pressure, while maintaining efficient attachment to the host receptor. Wu et al. here identify the complex epistatic network in RBS of H3N2 viruses that limits reversibility of naturally occurring mutations to retain infectivity.Nicholas C. WuAndrew J. ThompsonJia XieChih-Wei LinCorwin M. NycholatXueyong ZhuRichard A. LernerJames C. PaulsonIan A. WilsonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas C. Wu Andrew J. Thompson Jia Xie Chih-Wei Lin Corwin M. Nycholat Xueyong Zhu Richard A. Lerner James C. Paulson Ian A. Wilson A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site
description	The receptor-binding site (RBS) of influenza A viruses evolves to evade immune pressure, while maintaining efficient attachment to the host receptor. Wu et al. here identify the complex epistatic network in RBS of H3N2 viruses that limits reversibility of naturally occurring mutations to retain infectivity.
format	article
author	Nicholas C. Wu Andrew J. Thompson Jia Xie Chih-Wei Lin Corwin M. Nycholat Xueyong Zhu Richard A. Lerner James C. Paulson Ian A. Wilson
author_facet	Nicholas C. Wu Andrew J. Thompson Jia Xie Chih-Wei Lin Corwin M. Nycholat Xueyong Zhu Richard A. Lerner James C. Paulson Ian A. Wilson
author_sort	Nicholas C. Wu
title	A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site
title_short	A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site
title_full	A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site
title_fullStr	A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site
title_full_unstemmed	A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site
title_sort	complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0ae0a838cecb4e899bae6363fc59982b
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A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site

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