The Impacts of Synbiotic Supplementation on Periodontal Indices and Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus Patients with Chronic Periodontitis Under Non-Surgical Periodontal Therapy. A Double-Blind, Placebo-Controlled Trial

The Impacts of Synbiotic Supplementation on Periodontal Indices and Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus Patients with Chronic Periodontitis Under Non-Surgical Periodontal Therapy. A Double-Blind, Placebo-Controlled Trial

Hadi Bazyar,1,2 Leila Maghsoumi-Norouzabad,3 Mohsen Yarahmadi,3 Hassan Gholinezhad,3 Leila Moradi,4 Parvin Salehi,5 Mohammad Hosein Haghighi-zadeh,6 Ahmad Zare Javid1,3 1Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 2Student Research...

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Autores principales: Bazyar H, Maghsoumi-Norouzabad L, Yarahmadi M, Gholinezhad H, Moradi L, Salehi P, Haghighi-zadeh MH, Zare Javid A
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
type 2 diabetes mellitus
inflammation
antioxidant
periodontal disease
synbiotic
non-surgical periodontal therapy
Specialties of internal medicine
RC581-951
Acceso en línea:https://doaj.org/article/0ae370ee4f464817a7f3477fa1243fef
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spelling oai:doaj.org-article:0ae370ee4f464817a7f3477fa1243fef2021-12-02T04:40:52ZThe Impacts of Synbiotic Supplementation on Periodontal Indices and Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus Patients with Chronic Periodontitis Under Non-Surgical Periodontal Therapy. A Double-Blind, Placebo-Controlled Trial1178-7007https://doaj.org/article/0ae370ee4f464817a7f3477fa1243fef2020-01-01T00:00:00Zhttps://www.dovepress.com/the-impacts-of-synbiotic-supplementation-on-periodontal-indices-and-bi-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Hadi Bazyar,1,2 Leila Maghsoumi-Norouzabad,3 Mohsen Yarahmadi,3 Hassan Gholinezhad,3 Leila Moradi,4 Parvin Salehi,5 Mohammad Hosein Haghighi-zadeh,6 Ahmad Zare Javid1,3 1Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 2Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 3Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 4Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 5Department of Periodontology, School of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 6Department of Biostatistics, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranCorrespondence: Ahmad Zare JavidNutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranTel +98 914 317 6237Email ahmaddjavid@gmail.comAim: The aim of the current study was to investigate that combination of the synbiotic supplementation in adjunct with non-surgical periodontal therapy (NSPT) is useful in treating periodontitis and biomarkers of oxidative stress in type 2 diabetes mellitus (T2DM) patients.Methods: In this study, 47 patients suffering from DM and CP were recruited and randomly assigned to two groups. The intervention (n= 23) and control (n=24) groups received either multispecies probiotic supplement plus 100 mg fructo-oligosaccharide (500 mg in each capsule) or placebo capsule containing 500 mg wheat flour, respectively, every day for 8 weeks. All subjects were treated with NSPT during the intervention period. Serum levels of interleukin-1β (IL-1β), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and periodontal indices including clinical attachment loss (CAL), pocket depth (PD) (main outcome), BOP, and plaque index were measured before and after the intervention.Results: Supplementation with the synbiotic with NSPT led to a significant decrease in the levels of IL-1β, MDA, plaque index, PD, and CAL in the intervention group post-intervention (p < 0.05). The serum levels of TAC, SOD, and GPx were significantly increased in the intervention group compared with the baseline (p < 0.05). Consumption of synbiotic with NSPT, compared to the control, resulted in a significant decrease in the mean changes of IL-1β, MDA, and CAL (p < 0.05). Also, the mean changes of TAC and GPx were significantly higher in the intervention group compared with the control group (p < 0.05). Also, in the intervention group was seen a significant reduction in plaque index (p = 0.035) and BOP (p = 0.04) compared with the control group.Conclusion: It was observed that synbiotic supplementation with NSPT may be beneficial in improving inflammatory, antioxidant, and periodontal status in T2DM patients with CP.Keywords: type 2 diabetes mellitus, inflammation, antioxidant, periodontal disease, synbiotic, non-surgical periodontal therapyBazyar HMaghsoumi-Norouzabad LYarahmadi MGholinezhad HMoradi LSalehi PHaghighi-zadeh MHZare Javid ADove Medical Pressarticletype 2 diabetes mellitusinflammationantioxidantperiodontal diseasesynbioticnon-surgical periodontal therapySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 19-29 (2020)
institution DOAJ
collection DOAJ
language EN
topic type 2 diabetes mellitus
inflammation
antioxidant
periodontal disease
synbiotic
non-surgical periodontal therapy
Specialties of internal medicine
RC581-951
spellingShingle type 2 diabetes mellitus
inflammation
antioxidant
periodontal disease
synbiotic
non-surgical periodontal therapy
Specialties of internal medicine
RC581-951
Bazyar H
Maghsoumi-Norouzabad L
Yarahmadi M
Gholinezhad H
Moradi L
Salehi P
Haghighi-zadeh MH
Zare Javid A
The Impacts of Synbiotic Supplementation on Periodontal Indices and Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus Patients with Chronic Periodontitis Under Non-Surgical Periodontal Therapy. A Double-Blind, Placebo-Controlled Trial
description Hadi Bazyar,1,2 Leila Maghsoumi-Norouzabad,3 Mohsen Yarahmadi,3 Hassan Gholinezhad,3 Leila Moradi,4 Parvin Salehi,5 Mohammad Hosein Haghighi-zadeh,6 Ahmad Zare Javid1,3 1Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 2Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 3Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 4Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 5Department of Periodontology, School of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 6Department of Biostatistics, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranCorrespondence: Ahmad Zare JavidNutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranTel +98 914 317 6237Email ahmaddjavid@gmail.comAim: The aim of the current study was to investigate that combination of the synbiotic supplementation in adjunct with non-surgical periodontal therapy (NSPT) is useful in treating periodontitis and biomarkers of oxidative stress in type 2 diabetes mellitus (T2DM) patients.Methods: In this study, 47 patients suffering from DM and CP were recruited and randomly assigned to two groups. The intervention (n= 23) and control (n=24) groups received either multispecies probiotic supplement plus 100 mg fructo-oligosaccharide (500 mg in each capsule) or placebo capsule containing 500 mg wheat flour, respectively, every day for 8 weeks. All subjects were treated with NSPT during the intervention period. Serum levels of interleukin-1β (IL-1β), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and periodontal indices including clinical attachment loss (CAL), pocket depth (PD) (main outcome), BOP, and plaque index were measured before and after the intervention.Results: Supplementation with the synbiotic with NSPT led to a significant decrease in the levels of IL-1β, MDA, plaque index, PD, and CAL in the intervention group post-intervention (p < 0.05). The serum levels of TAC, SOD, and GPx were significantly increased in the intervention group compared with the baseline (p < 0.05). Consumption of synbiotic with NSPT, compared to the control, resulted in a significant decrease in the mean changes of IL-1β, MDA, and CAL (p < 0.05). Also, the mean changes of TAC and GPx were significantly higher in the intervention group compared with the control group (p < 0.05). Also, in the intervention group was seen a significant reduction in plaque index (p = 0.035) and BOP (p = 0.04) compared with the control group.Conclusion: It was observed that synbiotic supplementation with NSPT may be beneficial in improving inflammatory, antioxidant, and periodontal status in T2DM patients with CP.Keywords: type 2 diabetes mellitus, inflammation, antioxidant, periodontal disease, synbiotic, non-surgical periodontal therapy
format article
author Bazyar H
Maghsoumi-Norouzabad L
Yarahmadi M
Gholinezhad H
Moradi L
Salehi P
Haghighi-zadeh MH
Zare Javid A
author_facet Bazyar H
Maghsoumi-Norouzabad L
Yarahmadi M
Gholinezhad H
Moradi L
Salehi P
Haghighi-zadeh MH
Zare Javid A
author_sort Bazyar H
title The Impacts of Synbiotic Supplementation on Periodontal Indices and Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus Patients with Chronic Periodontitis Under Non-Surgical Periodontal Therapy. A Double-Blind, Placebo-Controlled Trial
title_short The Impacts of Synbiotic Supplementation on Periodontal Indices and Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus Patients with Chronic Periodontitis Under Non-Surgical Periodontal Therapy. A Double-Blind, Placebo-Controlled Trial
title_full The Impacts of Synbiotic Supplementation on Periodontal Indices and Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus Patients with Chronic Periodontitis Under Non-Surgical Periodontal Therapy. A Double-Blind, Placebo-Controlled Trial
title_fullStr The Impacts of Synbiotic Supplementation on Periodontal Indices and Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus Patients with Chronic Periodontitis Under Non-Surgical Periodontal Therapy. A Double-Blind, Placebo-Controlled Trial
title_full_unstemmed The Impacts of Synbiotic Supplementation on Periodontal Indices and Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus Patients with Chronic Periodontitis Under Non-Surgical Periodontal Therapy. A Double-Blind, Placebo-Controlled Trial
title_sort impacts of synbiotic supplementation on periodontal indices and biomarkers of oxidative stress in type 2 diabetes mellitus patients with chronic periodontitis under non-surgical periodontal therapy. a double-blind, placebo-controlled trial
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/0ae370ee4f464817a7f3477fa1243fef
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