Initial study of sediment antagonism and characteristics of silver nanoparticle-coated biliary stents in an experimental animal model

Yigeng Tian,1,* Mingfeng Xia,2,* Shuai Zhang,3 Zhen Fu,4 Qingbin Wen,2 Feng Liu,4 Zongzhen Xu,4 Tao Li,4 Hu Tian4 1Department of Physics, School of Physics and Technology, University of Jinan, Jinan, Shandong, People’s Republic of China; 2Department of Surgery, Shandong University of Trad...

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Autores principales:	Tian Y, Xia M, Zhang S, Fu Z, Wen Q, Liu F, Xu Z, Li T, Tian H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	silver nanoparticles biliary stent stent sediment characterization animal experiment Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0ae68fc4cf684f8885d7af8a4bfb9382
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spelling	oai:doaj.org-article:0ae68fc4cf684f8885d7af8a4bfb93822021-12-02T05:10:43ZInitial study of sediment antagonism and characteristics of silver nanoparticle-coated biliary stents in an experimental animal model1178-2013https://doaj.org/article/0ae68fc4cf684f8885d7af8a4bfb93822016-04-01T00:00:00Zhttps://www.dovepress.com/initial-study-of-sediment-antagonism-and-characteristics-of-silver-nan-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yigeng Tian,1,* Mingfeng Xia,2,* Shuai Zhang,3 Zhen Fu,4 Qingbin Wen,2 Feng Liu,4 Zongzhen Xu,4 Tao Li,4 Hu Tian4 1Department of Physics, School of Physics and Technology, University of Jinan, Jinan, Shandong, People’s Republic of China; 2Department of Surgery, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of China; 3Department of General Surgery, Sixth People’s Hospital of Jinan, Jinan, Shandong, People’s Republic of China; 4Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, People’s Republic of China *These authors contributed equally to this work Objective: Plastic biliary stents used to relieve obstructive jaundice are frequently blocked by sediment, resulting in loss of drainage. We prepared stents coated with silver nanoparticles (AgNPs) and compared their ability to resist sedimentation with Teflon stents in a beagle model of obstructive jaundice.Methods: AgNP-coated Teflon biliary stents were prepared by chemical oxidation–reduction and evaluated in an obstructive jaundice model that was produced by ligation of common bile duct (CBD); animals were randomized to two equal groups for placement of AgNP-coated or Teflon control stents. Liver function and inflammatory index were found to be similar in the two groups, and the obstruction was relieved. Stents were removed 21 days after insertion and observed by scanning and transmission electron microscopy. The AgNP coating was analyzed by energy dispersive X-ray analysis (EDXA), and the composition of sediment was assayed by Fourier-transform infrared (FTIR) spectroscopy.Results: Electron microscopy revealed a black, closely adherent AgNP stent coating, with thicknesses of 1.5–6 µm. Sediment thickness and density were greater on Teflon than on AgNP-coated stents. EDXA confirmed the stability and integrity of the AgNP coating before and after in vivo animal experimentation. FTIR spectroscopy identified stent sediment components including bilirubin, cholesterol, bile acid, protein, calcium, and other substances.Conclusion: AgNP-coated biliary stents resisted sediment accumulation in this canine model of obstructive jaundice caused by ligation of the CBD. Keywords: silver nanoparticles, biliary stent, stent sediment, characterization, animal modelTian YXia MZhang SFu ZWen QLiu FXu ZLi TTian HDove Medical Pressarticlesilver nanoparticlesbiliary stentstent sedimentcharacterizationanimal experimentMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 1807-1817 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	silver nanoparticles biliary stent stent sediment characterization animal experiment Medicine (General) R5-920
spellingShingle	silver nanoparticles biliary stent stent sediment characterization animal experiment Medicine (General) R5-920 Tian Y Xia M Zhang S Fu Z Wen Q Liu F Xu Z Li T Tian H Initial study of sediment antagonism and characteristics of silver nanoparticle-coated biliary stents in an experimental animal model
description	Yigeng Tian,1,* Mingfeng Xia,2,* Shuai Zhang,3 Zhen Fu,4 Qingbin Wen,2 Feng Liu,4 Zongzhen Xu,4 Tao Li,4 Hu Tian4 1Department of Physics, School of Physics and Technology, University of Jinan, Jinan, Shandong, People’s Republic of China; 2Department of Surgery, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of China; 3Department of General Surgery, Sixth People’s Hospital of Jinan, Jinan, Shandong, People’s Republic of China; 4Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, People’s Republic of China *These authors contributed equally to this work Objective: Plastic biliary stents used to relieve obstructive jaundice are frequently blocked by sediment, resulting in loss of drainage. We prepared stents coated with silver nanoparticles (AgNPs) and compared their ability to resist sedimentation with Teflon stents in a beagle model of obstructive jaundice.Methods: AgNP-coated Teflon biliary stents were prepared by chemical oxidation–reduction and evaluated in an obstructive jaundice model that was produced by ligation of common bile duct (CBD); animals were randomized to two equal groups for placement of AgNP-coated or Teflon control stents. Liver function and inflammatory index were found to be similar in the two groups, and the obstruction was relieved. Stents were removed 21 days after insertion and observed by scanning and transmission electron microscopy. The AgNP coating was analyzed by energy dispersive X-ray analysis (EDXA), and the composition of sediment was assayed by Fourier-transform infrared (FTIR) spectroscopy.Results: Electron microscopy revealed a black, closely adherent AgNP stent coating, with thicknesses of 1.5–6 µm. Sediment thickness and density were greater on Teflon than on AgNP-coated stents. EDXA confirmed the stability and integrity of the AgNP coating before and after in vivo animal experimentation. FTIR spectroscopy identified stent sediment components including bilirubin, cholesterol, bile acid, protein, calcium, and other substances.Conclusion: AgNP-coated biliary stents resisted sediment accumulation in this canine model of obstructive jaundice caused by ligation of the CBD. Keywords: silver nanoparticles, biliary stent, stent sediment, characterization, animal model
format	article
author	Tian Y Xia M Zhang S Fu Z Wen Q Liu F Xu Z Li T Tian H
author_facet	Tian Y Xia M Zhang S Fu Z Wen Q Liu F Xu Z Li T Tian H
author_sort	Tian Y
title	Initial study of sediment antagonism and characteristics of silver nanoparticle-coated biliary stents in an experimental animal model
title_short	Initial study of sediment antagonism and characteristics of silver nanoparticle-coated biliary stents in an experimental animal model
title_full	Initial study of sediment antagonism and characteristics of silver nanoparticle-coated biliary stents in an experimental animal model
title_fullStr	Initial study of sediment antagonism and characteristics of silver nanoparticle-coated biliary stents in an experimental animal model
title_full_unstemmed	Initial study of sediment antagonism and characteristics of silver nanoparticle-coated biliary stents in an experimental animal model
title_sort	initial study of sediment antagonism and characteristics of silver nanoparticle-coated biliary stents in an experimental animal model
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/0ae68fc4cf684f8885d7af8a4bfb9382
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Initial study of sediment antagonism and characteristics of silver nanoparticle-coated biliary stents in an experimental animal model

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