Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults

The immune response to vaccination with SARS-CoV-2 vaccines varies greatly from person to person. In addition to age, there is evidence that certain micronutrients influence the immune system, particularly vitamin D. Here, we analysed SARS-CoV-2 IgG and neutralisation potency along with 25-hydroxy-c...

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Autores principales:	Thilo Samson Chillon, Kamil Demircan, Raban Arved Heller, Ines Maria Hirschbil-Bremer, Joachim Diegmann, Manuel Bachmann, Arash Moghaddam, Lutz Schomburg
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vitamins vaccine humoral response SARS-CoV-2 immunology nutrition Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0aeb9d53de6b426ba9ae745b9ea36661
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id	oai:doaj.org-article:0aeb9d53de6b426ba9ae745b9ea36661
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spelling	oai:doaj.org-article:0aeb9d53de6b426ba9ae745b9ea366612021-11-25T16:51:13ZRelationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults10.3390/biomedicines91117142227-9059https://doaj.org/article/0aeb9d53de6b426ba9ae745b9ea366612021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1714https://doaj.org/toc/2227-9059The immune response to vaccination with SARS-CoV-2 vaccines varies greatly from person to person. In addition to age, there is evidence that certain micronutrients influence the immune system, particularly vitamin D. Here, we analysed SARS-CoV-2 IgG and neutralisation potency along with 25-hydroxy-cholecalciferol [25(OH)D] concentrations in a cohort of healthy German adults from the time of vaccination over 24 weeks. Contrary to our expectations, no significant differences were found in the dynamic increase or decrease of SARS-CoV-2 IgG as a function of the 25(OH)D status. Furthermore, the response to the first or second vaccination, the maximum SARS-CoV-2 IgG concentrations achieved, and the decline in SARS-CoV-2 IgG concentrations over time were not related to 25(OH)D status. We conclude that the vaccination response, measured as SARS-CoV-2 IgG concentration, does not depend on 25(OH)D status in healthy adults with moderate vitamin D status.Thilo Samson ChillonKamil DemircanRaban Arved HellerInes Maria Hirschbil-BremerJoachim DiegmannManuel BachmannArash MoghaddamLutz SchomburgMDPI AGarticlevitaminsvaccinehumoral responseSARS-CoV-2immunologynutritionBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1714, p 1714 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamins vaccine humoral response SARS-CoV-2 immunology nutrition Biology (General) QH301-705.5
spellingShingle	vitamins vaccine humoral response SARS-CoV-2 immunology nutrition Biology (General) QH301-705.5 Thilo Samson Chillon Kamil Demircan Raban Arved Heller Ines Maria Hirschbil-Bremer Joachim Diegmann Manuel Bachmann Arash Moghaddam Lutz Schomburg Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults
description	The immune response to vaccination with SARS-CoV-2 vaccines varies greatly from person to person. In addition to age, there is evidence that certain micronutrients influence the immune system, particularly vitamin D. Here, we analysed SARS-CoV-2 IgG and neutralisation potency along with 25-hydroxy-cholecalciferol [25(OH)D] concentrations in a cohort of healthy German adults from the time of vaccination over 24 weeks. Contrary to our expectations, no significant differences were found in the dynamic increase or decrease of SARS-CoV-2 IgG as a function of the 25(OH)D status. Furthermore, the response to the first or second vaccination, the maximum SARS-CoV-2 IgG concentrations achieved, and the decline in SARS-CoV-2 IgG concentrations over time were not related to 25(OH)D status. We conclude that the vaccination response, measured as SARS-CoV-2 IgG concentration, does not depend on 25(OH)D status in healthy adults with moderate vitamin D status.
format	article
author	Thilo Samson Chillon Kamil Demircan Raban Arved Heller Ines Maria Hirschbil-Bremer Joachim Diegmann Manuel Bachmann Arash Moghaddam Lutz Schomburg
author_facet	Thilo Samson Chillon Kamil Demircan Raban Arved Heller Ines Maria Hirschbil-Bremer Joachim Diegmann Manuel Bachmann Arash Moghaddam Lutz Schomburg
author_sort	Thilo Samson Chillon
title	Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults
title_short	Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults
title_full	Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults
title_fullStr	Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults
title_full_unstemmed	Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults
title_sort	relationship between vitamin d status and antibody response to covid-19 mrna vaccination in healthy adults
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0aeb9d53de6b426ba9ae745b9ea36661
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Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults

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