Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation

Dhar et al used primary human and mouse natural killer (NK) cells to demonstrate that tumor-derived NKG2D ligand soluble MIC (sMIC) can reprogram the NK cells to secrete pro-tumorigenic cytokines with diminished cytotoxicity and polyfunctional potential. Their study provides a rationale for co-targe...

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Autores principales:	Payal Dhar, Fahmin Basher, Zhe Ji, Lei Huang, Si Qin, Derek A. Wainwright, Jerid Robinson, Shaye Hagler, Jing Zhou, Sean MacKay, Jennifer D. Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0aee9ce5734644cbbebb591f8c4256a4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:0aee9ce5734644cbbebb591f8c4256a42021-12-02T16:26:20ZTumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation10.1038/s42003-021-02440-32399-3642https://doaj.org/article/0aee9ce5734644cbbebb591f8c4256a42021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02440-3https://doaj.org/toc/2399-3642Dhar et al used primary human and mouse natural killer (NK) cells to demonstrate that tumor-derived NKG2D ligand soluble MIC (sMIC) can reprogram the NK cells to secrete pro-tumorigenic cytokines with diminished cytotoxicity and polyfunctional potential. Their study provides a rationale for co-targeting sMIC in order to enhance current NK cell-based cancer immunotherapies.Payal DharFahmin BasherZhe JiLei HuangSi QinDerek A. WainwrightJerid RobinsonShaye HaglerJing ZhouSean MacKayJennifer D. WuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Payal Dhar Fahmin Basher Zhe Ji Lei Huang Si Qin Derek A. Wainwright Jerid Robinson Shaye Hagler Jing Zhou Sean MacKay Jennifer D. Wu Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation
description	Dhar et al used primary human and mouse natural killer (NK) cells to demonstrate that tumor-derived NKG2D ligand soluble MIC (sMIC) can reprogram the NK cells to secrete pro-tumorigenic cytokines with diminished cytotoxicity and polyfunctional potential. Their study provides a rationale for co-targeting sMIC in order to enhance current NK cell-based cancer immunotherapies.
format	article
author	Payal Dhar Fahmin Basher Zhe Ji Lei Huang Si Qin Derek A. Wainwright Jerid Robinson Shaye Hagler Jing Zhou Sean MacKay Jennifer D. Wu
author_facet	Payal Dhar Fahmin Basher Zhe Ji Lei Huang Si Qin Derek A. Wainwright Jerid Robinson Shaye Hagler Jing Zhou Sean MacKay Jennifer D. Wu
author_sort	Payal Dhar
title	Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation
title_short	Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation
title_full	Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation
title_fullStr	Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation
title_full_unstemmed	Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation
title_sort	tumor-derived nkg2d ligand smic reprograms nk cells to an inflammatory phenotype through cbm signalosome activation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0aee9ce5734644cbbebb591f8c4256a4
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Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation

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