Towards the human colorectal cancer microbiome.

Multiple factors drive the progression from healthy mucosa towards sporadic colorectal carcinomas and accumulating evidence associates intestinal bacteria with disease initiation and progression. Therefore, the aim of this study was to provide a first high-resolution map of colonic dysbiosis that is...

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Autores principales:	Julian R Marchesi, Bas E Dutilh, Neil Hall, Wilbert H M Peters, Rian Roelofs, Annemarie Boleij, Harold Tjalsma
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0aefc029d02a40a39a36e3c92f3ff515
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spelling	oai:doaj.org-article:0aefc029d02a40a39a36e3c92f3ff5152021-11-18T06:53:20ZTowards the human colorectal cancer microbiome.1932-620310.1371/journal.pone.0020447https://doaj.org/article/0aefc029d02a40a39a36e3c92f3ff5152011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21647227/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Multiple factors drive the progression from healthy mucosa towards sporadic colorectal carcinomas and accumulating evidence associates intestinal bacteria with disease initiation and progression. Therefore, the aim of this study was to provide a first high-resolution map of colonic dysbiosis that is associated with human colorectal cancer (CRC). To this purpose, the microbiomes colonizing colon tumor tissue and adjacent non-malignant mucosa were compared by deep rRNA sequencing. The results revealed striking differences in microbial colonization patterns between these two sites. Although inter-individual colonization in CRC patients was variable, tumors consistently formed a niche for Coriobacteria and other proposed probiotic bacterial species, while potentially pathogenic Enterobacteria were underrepresented in tumor tissue. As the intestinal microbiota is generally stable during adult life, these findings suggest that CRC-associated physiological and metabolic changes recruit tumor-foraging commensal-like bacteria. These microbes thus have an apparent competitive advantage in the tumor microenvironment and thereby seem to replace pathogenic bacteria that may be implicated in CRC etiology. This first glimpse of the CRC microbiome provides an important step towards full understanding of the dynamic interplay between intestinal microbial ecology and sporadic CRC, which may provide important leads towards novel microbiome-related diagnostic tools and therapeutic interventions.Julian R MarchesiBas E DutilhNeil HallWilbert H M PetersRian RoelofsAnnemarie BoleijHarold TjalsmaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e20447 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julian R Marchesi Bas E Dutilh Neil Hall Wilbert H M Peters Rian Roelofs Annemarie Boleij Harold Tjalsma Towards the human colorectal cancer microbiome.
description	Multiple factors drive the progression from healthy mucosa towards sporadic colorectal carcinomas and accumulating evidence associates intestinal bacteria with disease initiation and progression. Therefore, the aim of this study was to provide a first high-resolution map of colonic dysbiosis that is associated with human colorectal cancer (CRC). To this purpose, the microbiomes colonizing colon tumor tissue and adjacent non-malignant mucosa were compared by deep rRNA sequencing. The results revealed striking differences in microbial colonization patterns between these two sites. Although inter-individual colonization in CRC patients was variable, tumors consistently formed a niche for Coriobacteria and other proposed probiotic bacterial species, while potentially pathogenic Enterobacteria were underrepresented in tumor tissue. As the intestinal microbiota is generally stable during adult life, these findings suggest that CRC-associated physiological and metabolic changes recruit tumor-foraging commensal-like bacteria. These microbes thus have an apparent competitive advantage in the tumor microenvironment and thereby seem to replace pathogenic bacteria that may be implicated in CRC etiology. This first glimpse of the CRC microbiome provides an important step towards full understanding of the dynamic interplay between intestinal microbial ecology and sporadic CRC, which may provide important leads towards novel microbiome-related diagnostic tools and therapeutic interventions.
format	article
author	Julian R Marchesi Bas E Dutilh Neil Hall Wilbert H M Peters Rian Roelofs Annemarie Boleij Harold Tjalsma
author_facet	Julian R Marchesi Bas E Dutilh Neil Hall Wilbert H M Peters Rian Roelofs Annemarie Boleij Harold Tjalsma
author_sort	Julian R Marchesi
title	Towards the human colorectal cancer microbiome.
title_short	Towards the human colorectal cancer microbiome.
title_full	Towards the human colorectal cancer microbiome.
title_fullStr	Towards the human colorectal cancer microbiome.
title_full_unstemmed	Towards the human colorectal cancer microbiome.
title_sort	towards the human colorectal cancer microbiome.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/0aefc029d02a40a39a36e3c92f3ff515
work_keys_str_mv	AT julianrmarchesi towardsthehumancolorectalcancermicrobiome AT basedutilh towardsthehumancolorectalcancermicrobiome AT neilhall towardsthehumancolorectalcancermicrobiome AT wilberthmpeters towardsthehumancolorectalcancermicrobiome AT rianroelofs towardsthehumancolorectalcancermicrobiome AT annemarieboleij towardsthehumancolorectalcancermicrobiome AT haroldtjalsma towardsthehumancolorectalcancermicrobiome
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Towards the human colorectal cancer microbiome.

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