Serum MicroRNA Expression Patterns in Subjects After the 5-km Exercise Are Strongly Associated With Cardiovascular Adaptation

Circulating microRNAs (miRNAs) have been reported dysregulated during exercise. However, the changes of specific serum miRNAs during the 5-km run test with intensity of 51–52% maximum oxygen uptake (V̇O2max) and their association with traditional cardiovascular-related indicators remain well-charact...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dandan Li, Pingping Wang, Wenyan Wei, Cheng Wang, Yong Zhong, Lei Lv, Junjun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	5-km run test exercise microRNAs cardiovascular disease adaptation Physiology QP1-981
Acceso en línea:	https://doaj.org/article/0af263554dd248d89653e7f68a342830
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0af263554dd248d89653e7f68a342830
record_format	dspace
spelling	oai:doaj.org-article:0af263554dd248d89653e7f68a3428302021-12-01T13:19:52ZSerum MicroRNA Expression Patterns in Subjects After the 5-km Exercise Are Strongly Associated With Cardiovascular Adaptation1664-042X10.3389/fphys.2021.755656https://doaj.org/article/0af263554dd248d89653e7f68a3428302021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.755656/fullhttps://doaj.org/toc/1664-042XCirculating microRNAs (miRNAs) have been reported dysregulated during exercise. However, the changes of specific serum miRNAs during the 5-km run test with intensity of 51–52% maximum oxygen uptake (V̇O2max) and their association with traditional cardiovascular-related indicators remain well-characterized. Levels of miR-1, miR-21, miR-146a, miR-155, miR-181, and miR-210 were detected in 120 young subjects before and after the exercise training by quantitative reverse-transcription PCR (RT-qPCR). Besides, the levels of cardiac troponin I (cTNI), myoglobin (Myo), creatine kinase (CK), creatine kinase-MB (CK-MB), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), ischemia-modified albumin (IMA), interleukin-6 (IL-6), and C-reactive protein (CRP) were measured and the correlation between levels of serum miRNAs and biochemical parameters was also analyzed. Compared with resting state, the serum levels of miR-1, miR-146a, miR-155, miR-181, and miR-210 were significantly increased after exercise training. Serum levels of miR-146a, miR-155, and miR-210 after exercise training were positively correlated with Myo, CK-MB, and LDH, respectively, while miR-1, miR-146a, miR-181, and miR-155 were positively correlated with the levels of IL-6. Additionally, all the five miRNAs were negatively correlated with IMA levels. The multivariate logistic regression analysis showed that high levels of miR-146a, AST, LDH, and IL-6 in serum were risk factors, while low IMA contents were a protective factor for cardiovascular adaptation during exercise. In conclusion, the dynamic changes of miRNAs under the condition of the 5-km continuous running contribute to the adaptive regulation of the cardiovascular function of the body.Dandan LiPingping WangWenyan WeiCheng WangYong ZhongLei LvJunjun WangFrontiers Media S.A.article5-km run testexercisemicroRNAscardiovascular diseaseadaptationPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	5-km run test exercise microRNAs cardiovascular disease adaptation Physiology QP1-981
spellingShingle	5-km run test exercise microRNAs cardiovascular disease adaptation Physiology QP1-981 Dandan Li Pingping Wang Wenyan Wei Cheng Wang Yong Zhong Lei Lv Junjun Wang Serum MicroRNA Expression Patterns in Subjects After the 5-km Exercise Are Strongly Associated With Cardiovascular Adaptation
description	Circulating microRNAs (miRNAs) have been reported dysregulated during exercise. However, the changes of specific serum miRNAs during the 5-km run test with intensity of 51–52% maximum oxygen uptake (V̇O2max) and their association with traditional cardiovascular-related indicators remain well-characterized. Levels of miR-1, miR-21, miR-146a, miR-155, miR-181, and miR-210 were detected in 120 young subjects before and after the exercise training by quantitative reverse-transcription PCR (RT-qPCR). Besides, the levels of cardiac troponin I (cTNI), myoglobin (Myo), creatine kinase (CK), creatine kinase-MB (CK-MB), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), ischemia-modified albumin (IMA), interleukin-6 (IL-6), and C-reactive protein (CRP) were measured and the correlation between levels of serum miRNAs and biochemical parameters was also analyzed. Compared with resting state, the serum levels of miR-1, miR-146a, miR-155, miR-181, and miR-210 were significantly increased after exercise training. Serum levels of miR-146a, miR-155, and miR-210 after exercise training were positively correlated with Myo, CK-MB, and LDH, respectively, while miR-1, miR-146a, miR-181, and miR-155 were positively correlated with the levels of IL-6. Additionally, all the five miRNAs were negatively correlated with IMA levels. The multivariate logistic regression analysis showed that high levels of miR-146a, AST, LDH, and IL-6 in serum were risk factors, while low IMA contents were a protective factor for cardiovascular adaptation during exercise. In conclusion, the dynamic changes of miRNAs under the condition of the 5-km continuous running contribute to the adaptive regulation of the cardiovascular function of the body.
format	article
author	Dandan Li Pingping Wang Wenyan Wei Cheng Wang Yong Zhong Lei Lv Junjun Wang
author_facet	Dandan Li Pingping Wang Wenyan Wei Cheng Wang Yong Zhong Lei Lv Junjun Wang
author_sort	Dandan Li
title	Serum MicroRNA Expression Patterns in Subjects After the 5-km Exercise Are Strongly Associated With Cardiovascular Adaptation
title_short	Serum MicroRNA Expression Patterns in Subjects After the 5-km Exercise Are Strongly Associated With Cardiovascular Adaptation
title_full	Serum MicroRNA Expression Patterns in Subjects After the 5-km Exercise Are Strongly Associated With Cardiovascular Adaptation
title_fullStr	Serum MicroRNA Expression Patterns in Subjects After the 5-km Exercise Are Strongly Associated With Cardiovascular Adaptation
title_full_unstemmed	Serum MicroRNA Expression Patterns in Subjects After the 5-km Exercise Are Strongly Associated With Cardiovascular Adaptation
title_sort	serum microrna expression patterns in subjects after the 5-km exercise are strongly associated with cardiovascular adaptation
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/0af263554dd248d89653e7f68a342830
work_keys_str_mv	AT dandanli serummicrornaexpressionpatternsinsubjectsafterthe5kmexercisearestronglyassociatedwithcardiovascularadaptation AT pingpingwang serummicrornaexpressionpatternsinsubjectsafterthe5kmexercisearestronglyassociatedwithcardiovascularadaptation AT wenyanwei serummicrornaexpressionpatternsinsubjectsafterthe5kmexercisearestronglyassociatedwithcardiovascularadaptation AT chengwang serummicrornaexpressionpatternsinsubjectsafterthe5kmexercisearestronglyassociatedwithcardiovascularadaptation AT yongzhong serummicrornaexpressionpatternsinsubjectsafterthe5kmexercisearestronglyassociatedwithcardiovascularadaptation AT leilv serummicrornaexpressionpatternsinsubjectsafterthe5kmexercisearestronglyassociatedwithcardiovascularadaptation AT junjunwang serummicrornaexpressionpatternsinsubjectsafterthe5kmexercisearestronglyassociatedwithcardiovascularadaptation
_version_	1718405099700617216

Serum MicroRNA Expression Patterns in Subjects After the 5-km Exercise Are Strongly Associated With Cardiovascular Adaptation

Ejemplares similares