HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions

The vitamin D receptor/retinoid X receptor-α heterodimer (VDRRXRα) regulates bone mineralization. Here the authors employ hydrogen/deuterium exchange (HDX) mass spectrometry to study the conformational dynamics of VDRRXRα and give mechanistic insights into how VDRRXRα controls the transcriptional ac...

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Autores principales:	Jie Zheng, Mi Ra Chang, Ryan E. Stites, Yong Wang, John B. Bruning, Bruce D. Pascal, Scott J. Novick, Ruben D. Garcia-Ordonez, Keith R. Stayrook, Michael J. Chalmers, Jeffrey A. Dodge, Patrick R. Griffin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0af27878e2d34bc4a8b0c9e67ce81c71
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spelling	oai:doaj.org-article:0af27878e2d34bc4a8b0c9e67ce81c712021-12-02T14:42:38ZHDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions10.1038/s41467-017-00978-72041-1723https://doaj.org/article/0af27878e2d34bc4a8b0c9e67ce81c712017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00978-7https://doaj.org/toc/2041-1723The vitamin D receptor/retinoid X receptor-α heterodimer (VDRRXRα) regulates bone mineralization. Here the authors employ hydrogen/deuterium exchange (HDX) mass spectrometry to study the conformational dynamics of VDRRXRα and give mechanistic insights into how VDRRXRα controls the transcriptional activity of specific genes.Jie ZhengMi Ra ChangRyan E. StitesYong WangJohn B. BruningBruce D. PascalScott J. NovickRuben D. Garcia-OrdonezKeith R. StayrookMichael J. ChalmersJeffrey A. DodgePatrick R. GriffinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jie Zheng Mi Ra Chang Ryan E. Stites Yong Wang John B. Bruning Bruce D. Pascal Scott J. Novick Ruben D. Garcia-Ordonez Keith R. Stayrook Michael J. Chalmers Jeffrey A. Dodge Patrick R. Griffin HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions
description	The vitamin D receptor/retinoid X receptor-α heterodimer (VDRRXRα) regulates bone mineralization. Here the authors employ hydrogen/deuterium exchange (HDX) mass spectrometry to study the conformational dynamics of VDRRXRα and give mechanistic insights into how VDRRXRα controls the transcriptional activity of specific genes.
format	article
author	Jie Zheng Mi Ra Chang Ryan E. Stites Yong Wang John B. Bruning Bruce D. Pascal Scott J. Novick Ruben D. Garcia-Ordonez Keith R. Stayrook Michael J. Chalmers Jeffrey A. Dodge Patrick R. Griffin
author_facet	Jie Zheng Mi Ra Chang Ryan E. Stites Yong Wang John B. Bruning Bruce D. Pascal Scott J. Novick Ruben D. Garcia-Ordonez Keith R. Stayrook Michael J. Chalmers Jeffrey A. Dodge Patrick R. Griffin
author_sort	Jie Zheng
title	HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions
title_short	HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions
title_full	HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions
title_fullStr	HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions
title_full_unstemmed	HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions
title_sort	hdx reveals the conformational dynamics of dna sequence specific vdr co-activator interactions
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0af27878e2d34bc4a8b0c9e67ce81c71
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HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions

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