Carboxymethylcellulose excipient allergy: a case report

Abstract Background Excipients are widely used in pharmaceuticals, detergents, food, and drink because of their properties of low toxicity and hypoallergenicity. The excipient carboxymethylcellulose is used extensively as a thickener in foods such as baked goods, ice cream, gluten free, and reduced...

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Autores principales:	Katherine Townsend, James Laffan, Grant Hayman
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Allergy Hypersensitivity Excipient Carboxymethylcellulose (CMC) Case report Medicine R
Acceso en línea:	https://doaj.org/article/0af5045c556e4a6f95802a3f6d01d82f
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spelling	oai:doaj.org-article:0af5045c556e4a6f95802a3f6d01d82f2021-11-28T12:37:17ZCarboxymethylcellulose excipient allergy: a case report10.1186/s13256-021-03180-y1752-1947https://doaj.org/article/0af5045c556e4a6f95802a3f6d01d82f2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13256-021-03180-yhttps://doaj.org/toc/1752-1947Abstract Background Excipients are widely used in pharmaceuticals, detergents, food, and drink because of their properties of low toxicity and hypoallergenicity. The excipient carboxymethylcellulose is used extensively as a thickener in foods such as baked goods, ice cream, gluten free, and reduced fat products, where it may be labeled as e-number E466. However, excipients can rarely cause type 1 hypersensitivity reactions. Several publications have described systemic allergy following carboxymethylcellulose exposure in pharmaceuticals, particularly systemic corticosteroids. Furthermore, there is one reported case in the literature of anaphylaxis following food containing carboxymethylcellulose. Case presentation We identify a case of anaphylaxis in a 45-year-old atopic Caucasian woman on receiving an injectable suspension of the corticosteroid triamcinolone acetonide containing carboxymethylcellulose, and subsequent allergic symptoms on reexposure to carboxymethylcellulose in a commercial drink. Diagnosis of carboxymethylcellulose excipient allergy was confirmed through skin prick testing using Celluvisc carmellose 0.5% eye drops, which contain carboxymethylcellulose as the active ingredient. Conclusion This case highlights the importance of identifying excipients such as carboxymethylcellulose as causes of allergy, to reduce burden of further hypersensitivity reactions, not just to drugs but to other consumables.Katherine TownsendJames LaffanGrant HaymanBMCarticleAllergyHypersensitivityExcipientCarboxymethylcellulose (CMC)Case reportMedicineRENJournal of Medical Case Reports, Vol 15, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Allergy Hypersensitivity Excipient Carboxymethylcellulose (CMC) Case report Medicine R
spellingShingle	Allergy Hypersensitivity Excipient Carboxymethylcellulose (CMC) Case report Medicine R Katherine Townsend James Laffan Grant Hayman Carboxymethylcellulose excipient allergy: a case report
description	Abstract Background Excipients are widely used in pharmaceuticals, detergents, food, and drink because of their properties of low toxicity and hypoallergenicity. The excipient carboxymethylcellulose is used extensively as a thickener in foods such as baked goods, ice cream, gluten free, and reduced fat products, where it may be labeled as e-number E466. However, excipients can rarely cause type 1 hypersensitivity reactions. Several publications have described systemic allergy following carboxymethylcellulose exposure in pharmaceuticals, particularly systemic corticosteroids. Furthermore, there is one reported case in the literature of anaphylaxis following food containing carboxymethylcellulose. Case presentation We identify a case of anaphylaxis in a 45-year-old atopic Caucasian woman on receiving an injectable suspension of the corticosteroid triamcinolone acetonide containing carboxymethylcellulose, and subsequent allergic symptoms on reexposure to carboxymethylcellulose in a commercial drink. Diagnosis of carboxymethylcellulose excipient allergy was confirmed through skin prick testing using Celluvisc carmellose 0.5% eye drops, which contain carboxymethylcellulose as the active ingredient. Conclusion This case highlights the importance of identifying excipients such as carboxymethylcellulose as causes of allergy, to reduce burden of further hypersensitivity reactions, not just to drugs but to other consumables.
format	article
author	Katherine Townsend James Laffan Grant Hayman
author_facet	Katherine Townsend James Laffan Grant Hayman
author_sort	Katherine Townsend
title	Carboxymethylcellulose excipient allergy: a case report
title_short	Carboxymethylcellulose excipient allergy: a case report
title_full	Carboxymethylcellulose excipient allergy: a case report
title_fullStr	Carboxymethylcellulose excipient allergy: a case report
title_full_unstemmed	Carboxymethylcellulose excipient allergy: a case report
title_sort	carboxymethylcellulose excipient allergy: a case report
publisher	BMC
publishDate	2021
url	https://doaj.org/article/0af5045c556e4a6f95802a3f6d01d82f
work_keys_str_mv	AT katherinetownsend carboxymethylcelluloseexcipientallergyacasereport AT jameslaffan carboxymethylcelluloseexcipientallergyacasereport AT granthayman carboxymethylcelluloseexcipientallergyacasereport
_version_	1718407874182381568

Carboxymethylcellulose excipient allergy: a case report

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