Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies

Non-adherence to daily drug regimens is responsible for many negative clinical effects including drug resistance in life-long treatments for HIV. Here, the authors report on a HIV prodrug nanoparticle platform for long-acting sustained release of water-soluble drug compounds following injection.

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Autores principales:	James J. Hobson, Amer Al-khouja, Paul Curley, David Meyers, Charles Flexner, Marco Siccardi, Andrew Owen, Caren Freel Meyers, Steve P. Rannard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0af90520fd9449aa84b2d09b2855e9b8
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spelling	oai:doaj.org-article:0af90520fd9449aa84b2d09b2855e9b82021-12-02T17:01:31ZSemi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies10.1038/s41467-019-09354-z2041-1723https://doaj.org/article/0af90520fd9449aa84b2d09b2855e9b82019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09354-zhttps://doaj.org/toc/2041-1723Non-adherence to daily drug regimens is responsible for many negative clinical effects including drug resistance in life-long treatments for HIV. Here, the authors report on a HIV prodrug nanoparticle platform for long-acting sustained release of water-soluble drug compounds following injection.James J. HobsonAmer Al-khoujaPaul CurleyDavid MeyersCharles FlexnerMarco SiccardiAndrew OwenCaren Freel MeyersSteve P. RannardNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q James J. Hobson Amer Al-khouja Paul Curley David Meyers Charles Flexner Marco Siccardi Andrew Owen Caren Freel Meyers Steve P. Rannard Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies
description	Non-adherence to daily drug regimens is responsible for many negative clinical effects including drug resistance in life-long treatments for HIV. Here, the authors report on a HIV prodrug nanoparticle platform for long-acting sustained release of water-soluble drug compounds following injection.
format	article
author	James J. Hobson Amer Al-khouja Paul Curley David Meyers Charles Flexner Marco Siccardi Andrew Owen Caren Freel Meyers Steve P. Rannard
author_facet	James J. Hobson Amer Al-khouja Paul Curley David Meyers Charles Flexner Marco Siccardi Andrew Owen Caren Freel Meyers Steve P. Rannard
author_sort	James J. Hobson
title	Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies
title_short	Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies
title_full	Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies
title_fullStr	Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies
title_full_unstemmed	Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies
title_sort	semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination hiv therapies
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0af90520fd9449aa84b2d09b2855e9b8
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Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies

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