An Advanced Transcriptional Response to Corticosterone After Single Prolonged Stress in Male Rats

Stress-related neuropsychiatric disorders are often accompanied by dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis. In patients suffering from post-traumatic stress disorder (PTSD), increased sensitivity of glucocorticoid negative feedback has regularly been observed. The single prolong...

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Autores principales: Jinlan Ding, Xinzhao Chen, Fang Han, Onno C. Meijer
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Publicado: Frontiers Media S.A. 2021
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spelling oai:doaj.org-article:0af93ff8b838440f9ee3fb3e26c654142021-11-17T13:32:38ZAn Advanced Transcriptional Response to Corticosterone After Single Prolonged Stress in Male Rats1662-515310.3389/fnbeh.2021.756903https://doaj.org/article/0af93ff8b838440f9ee3fb3e26c654142021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnbeh.2021.756903/fullhttps://doaj.org/toc/1662-5153Stress-related neuropsychiatric disorders are often accompanied by dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis. In patients suffering from post-traumatic stress disorder (PTSD), increased sensitivity of glucocorticoid negative feedback has regularly been observed. The single prolonged stress (SPS) paradigm was developed to model increased negative feedback and other aspects of PTSD in rats. In this study, we used a setup that precluded the evaluation of negative feedback but rather served to test the hypothesis of the enhanced glucocorticoid receptor (GR) signaling in higher brain areas. We injected corticosterone or vehicle 7 days after SPS and evaluated plasma corticosterone, as well as gene expression in the dorsal hippocampus and amygdala. We observed a strikingly rapid change in the expression of established GR target genes (t = 30 min) only in the SPS group on exogenous corticosterone injection. Our results extend the notion of increased GR sensitivity in PTSD to include transcriptional responses in the hippocampus.Jinlan DingJinlan DingJinlan DingXinzhao ChenFang HanOnno C. MeijerOnno C. MeijerFrontiers Media S.A.articlenegative feedbackcorticosteroneGR sensitivityFKBP5hippocampusNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Behavioral Neuroscience, Vol 15 (2021)
institution DOAJ
collection DOAJ
language EN
topic negative feedback
corticosterone
GR sensitivity
FKBP5
hippocampus
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
spellingShingle negative feedback
corticosterone
GR sensitivity
FKBP5
hippocampus
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Jinlan Ding
Jinlan Ding
Jinlan Ding
Xinzhao Chen
Fang Han
Onno C. Meijer
Onno C. Meijer
An Advanced Transcriptional Response to Corticosterone After Single Prolonged Stress in Male Rats
description Stress-related neuropsychiatric disorders are often accompanied by dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis. In patients suffering from post-traumatic stress disorder (PTSD), increased sensitivity of glucocorticoid negative feedback has regularly been observed. The single prolonged stress (SPS) paradigm was developed to model increased negative feedback and other aspects of PTSD in rats. In this study, we used a setup that precluded the evaluation of negative feedback but rather served to test the hypothesis of the enhanced glucocorticoid receptor (GR) signaling in higher brain areas. We injected corticosterone or vehicle 7 days after SPS and evaluated plasma corticosterone, as well as gene expression in the dorsal hippocampus and amygdala. We observed a strikingly rapid change in the expression of established GR target genes (t = 30 min) only in the SPS group on exogenous corticosterone injection. Our results extend the notion of increased GR sensitivity in PTSD to include transcriptional responses in the hippocampus.
format article
author Jinlan Ding
Jinlan Ding
Jinlan Ding
Xinzhao Chen
Fang Han
Onno C. Meijer
Onno C. Meijer
author_facet Jinlan Ding
Jinlan Ding
Jinlan Ding
Xinzhao Chen
Fang Han
Onno C. Meijer
Onno C. Meijer
author_sort Jinlan Ding
title An Advanced Transcriptional Response to Corticosterone After Single Prolonged Stress in Male Rats
title_short An Advanced Transcriptional Response to Corticosterone After Single Prolonged Stress in Male Rats
title_full An Advanced Transcriptional Response to Corticosterone After Single Prolonged Stress in Male Rats
title_fullStr An Advanced Transcriptional Response to Corticosterone After Single Prolonged Stress in Male Rats
title_full_unstemmed An Advanced Transcriptional Response to Corticosterone After Single Prolonged Stress in Male Rats
title_sort advanced transcriptional response to corticosterone after single prolonged stress in male rats
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/0af93ff8b838440f9ee3fb3e26c65414
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