An Advanced Transcriptional Response to Corticosterone After Single Prolonged Stress in Male Rats
Stress-related neuropsychiatric disorders are often accompanied by dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis. In patients suffering from post-traumatic stress disorder (PTSD), increased sensitivity of glucocorticoid negative feedback has regularly been observed. The single prolong...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:0af93ff8b838440f9ee3fb3e26c654142021-11-17T13:32:38ZAn Advanced Transcriptional Response to Corticosterone After Single Prolonged Stress in Male Rats1662-515310.3389/fnbeh.2021.756903https://doaj.org/article/0af93ff8b838440f9ee3fb3e26c654142021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnbeh.2021.756903/fullhttps://doaj.org/toc/1662-5153Stress-related neuropsychiatric disorders are often accompanied by dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis. In patients suffering from post-traumatic stress disorder (PTSD), increased sensitivity of glucocorticoid negative feedback has regularly been observed. The single prolonged stress (SPS) paradigm was developed to model increased negative feedback and other aspects of PTSD in rats. In this study, we used a setup that precluded the evaluation of negative feedback but rather served to test the hypothesis of the enhanced glucocorticoid receptor (GR) signaling in higher brain areas. We injected corticosterone or vehicle 7 days after SPS and evaluated plasma corticosterone, as well as gene expression in the dorsal hippocampus and amygdala. We observed a strikingly rapid change in the expression of established GR target genes (t = 30 min) only in the SPS group on exogenous corticosterone injection. Our results extend the notion of increased GR sensitivity in PTSD to include transcriptional responses in the hippocampus.Jinlan DingJinlan DingJinlan DingXinzhao ChenFang HanOnno C. MeijerOnno C. MeijerFrontiers Media S.A.articlenegative feedbackcorticosteroneGR sensitivityFKBP5hippocampusNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Behavioral Neuroscience, Vol 15 (2021) |
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negative feedback corticosterone GR sensitivity FKBP5 hippocampus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
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negative feedback corticosterone GR sensitivity FKBP5 hippocampus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Jinlan Ding Jinlan Ding Jinlan Ding Xinzhao Chen Fang Han Onno C. Meijer Onno C. Meijer An Advanced Transcriptional Response to Corticosterone After Single Prolonged Stress in Male Rats |
description |
Stress-related neuropsychiatric disorders are often accompanied by dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis. In patients suffering from post-traumatic stress disorder (PTSD), increased sensitivity of glucocorticoid negative feedback has regularly been observed. The single prolonged stress (SPS) paradigm was developed to model increased negative feedback and other aspects of PTSD in rats. In this study, we used a setup that precluded the evaluation of negative feedback but rather served to test the hypothesis of the enhanced glucocorticoid receptor (GR) signaling in higher brain areas. We injected corticosterone or vehicle 7 days after SPS and evaluated plasma corticosterone, as well as gene expression in the dorsal hippocampus and amygdala. We observed a strikingly rapid change in the expression of established GR target genes (t = 30 min) only in the SPS group on exogenous corticosterone injection. Our results extend the notion of increased GR sensitivity in PTSD to include transcriptional responses in the hippocampus. |
format |
article |
author |
Jinlan Ding Jinlan Ding Jinlan Ding Xinzhao Chen Fang Han Onno C. Meijer Onno C. Meijer |
author_facet |
Jinlan Ding Jinlan Ding Jinlan Ding Xinzhao Chen Fang Han Onno C. Meijer Onno C. Meijer |
author_sort |
Jinlan Ding |
title |
An Advanced Transcriptional Response to Corticosterone After Single Prolonged Stress in Male Rats |
title_short |
An Advanced Transcriptional Response to Corticosterone After Single Prolonged Stress in Male Rats |
title_full |
An Advanced Transcriptional Response to Corticosterone After Single Prolonged Stress in Male Rats |
title_fullStr |
An Advanced Transcriptional Response to Corticosterone After Single Prolonged Stress in Male Rats |
title_full_unstemmed |
An Advanced Transcriptional Response to Corticosterone After Single Prolonged Stress in Male Rats |
title_sort |
advanced transcriptional response to corticosterone after single prolonged stress in male rats |
publisher |
Frontiers Media S.A. |
publishDate |
2021 |
url |
https://doaj.org/article/0af93ff8b838440f9ee3fb3e26c65414 |
work_keys_str_mv |
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