MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB

Amino acids stimulate cell growth and depletion in a cell activates autophagy, yet how this is regulated is unclear. Here, the authors show that MAP4K3 (also known as germinal-center kinase-like kinase) acts as an amino acid-dependent regulator of autophagy, via phosphorylation of the transcription...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cynthia L. Hsu, Elian X. Lee, Kara L. Gordon, Edwin A. Paz, Wen-Chuan Shen, Kohta Ohnishi, Jill Meisenhelder, Tony Hunter, Albert R. La Spada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0afb41f5096349c886cb519bbdbf6e4d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0afb41f5096349c886cb519bbdbf6e4d
record_format	dspace
spelling	oai:doaj.org-article:0afb41f5096349c886cb519bbdbf6e4d2021-12-02T15:33:38ZMAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB10.1038/s41467-018-03340-72041-1723https://doaj.org/article/0afb41f5096349c886cb519bbdbf6e4d2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03340-7https://doaj.org/toc/2041-1723Amino acids stimulate cell growth and depletion in a cell activates autophagy, yet how this is regulated is unclear. Here, the authors show that MAP4K3 (also known as germinal-center kinase-like kinase) acts as an amino acid-dependent regulator of autophagy, via phosphorylation of the transcription factor EB.Cynthia L. HsuElian X. LeeKara L. GordonEdwin A. PazWen-Chuan ShenKohta OhnishiJill MeisenhelderTony HunterAlbert R. La SpadaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cynthia L. Hsu Elian X. Lee Kara L. Gordon Edwin A. Paz Wen-Chuan Shen Kohta Ohnishi Jill Meisenhelder Tony Hunter Albert R. La Spada MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB
description	Amino acids stimulate cell growth and depletion in a cell activates autophagy, yet how this is regulated is unclear. Here, the authors show that MAP4K3 (also known as germinal-center kinase-like kinase) acts as an amino acid-dependent regulator of autophagy, via phosphorylation of the transcription factor EB.
format	article
author	Cynthia L. Hsu Elian X. Lee Kara L. Gordon Edwin A. Paz Wen-Chuan Shen Kohta Ohnishi Jill Meisenhelder Tony Hunter Albert R. La Spada
author_facet	Cynthia L. Hsu Elian X. Lee Kara L. Gordon Edwin A. Paz Wen-Chuan Shen Kohta Ohnishi Jill Meisenhelder Tony Hunter Albert R. La Spada
author_sort	Cynthia L. Hsu
title	MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB
title_short	MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB
title_full	MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB
title_fullStr	MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB
title_full_unstemmed	MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB
title_sort	map4k3 mediates amino acid-dependent regulation of autophagy via phosphorylation of tfeb
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0afb41f5096349c886cb519bbdbf6e4d
work_keys_str_mv	AT cynthialhsu map4k3mediatesaminoaciddependentregulationofautophagyviaphosphorylationoftfeb AT elianxlee map4k3mediatesaminoaciddependentregulationofautophagyviaphosphorylationoftfeb AT karalgordon map4k3mediatesaminoaciddependentregulationofautophagyviaphosphorylationoftfeb AT edwinapaz map4k3mediatesaminoaciddependentregulationofautophagyviaphosphorylationoftfeb AT wenchuanshen map4k3mediatesaminoaciddependentregulationofautophagyviaphosphorylationoftfeb AT kohtaohnishi map4k3mediatesaminoaciddependentregulationofautophagyviaphosphorylationoftfeb AT jillmeisenhelder map4k3mediatesaminoaciddependentregulationofautophagyviaphosphorylationoftfeb AT tonyhunter map4k3mediatesaminoaciddependentregulationofautophagyviaphosphorylationoftfeb AT albertrlaspada map4k3mediatesaminoaciddependentregulationofautophagyviaphosphorylationoftfeb
_version_	1718387064571953152

MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB

Ejemplares similares