MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB

MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB

Amino acids stimulate cell growth and depletion in a cell activates autophagy, yet how this is regulated is unclear. Here, the authors show that MAP4K3 (also known as germinal-center kinase-like kinase) acts as an amino acid-dependent regulator of autophagy, via phosphorylation of the transcription...

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Autores principales: Cynthia L. Hsu, Elian X. Lee, Kara L. Gordon, Edwin A. Paz, Wen-Chuan Shen, Kohta Ohnishi, Jill Meisenhelder, Tony Hunter, Albert R. La Spada
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/0afb41f5096349c886cb519bbdbf6e4d
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