Revealing the role of the human blood plasma proteome in obesity using genetic drivers

Revealing the role of the human blood plasma proteome in obesity using genetic drivers

Blood circulating proteins reflect biological processes, thus providing insight into complex traits. Here the authors study the relationship between 1000 plasma proteins and body mass index (BMI), highlighting widespread proteome changes and causal relationships between BMI and specific proteins.

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Autores principales: Shaza B. Zaghlool, Sapna Sharma, Megan Molnar, Pamela R. Matías-García, Mohamed A. Elhadad, Melanie Waldenberger, Annette Peters, Wolfgang Rathmann, Johannes Graumann, Christian Gieger, Harald Grallert, Karsten Suhre
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/0afbd25a06e148d5998f75500854222f
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spelling oai:doaj.org-article:0afbd25a06e148d5998f75500854222f2021-12-02T13:35:00ZRevealing the role of the human blood plasma proteome in obesity using genetic drivers10.1038/s41467-021-21542-42041-1723https://doaj.org/article/0afbd25a06e148d5998f75500854222f2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21542-4https://doaj.org/toc/2041-1723Blood circulating proteins reflect biological processes, thus providing insight into complex traits. Here the authors study the relationship between 1000 plasma proteins and body mass index (BMI), highlighting widespread proteome changes and causal relationships between BMI and specific proteins.Shaza B. ZaghloolSapna SharmaMegan MolnarPamela R. Matías-GarcíaMohamed A. ElhadadMelanie WaldenbergerAnnette PetersWolfgang RathmannJohannes GraumannChristian GiegerHarald GrallertKarsten SuhreNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shaza B. Zaghlool
Sapna Sharma
Megan Molnar
Pamela R. Matías-García
Mohamed A. Elhadad
Melanie Waldenberger
Annette Peters
Wolfgang Rathmann
Johannes Graumann
Christian Gieger
Harald Grallert
Karsten Suhre
Revealing the role of the human blood plasma proteome in obesity using genetic drivers
description Blood circulating proteins reflect biological processes, thus providing insight into complex traits. Here the authors study the relationship between 1000 plasma proteins and body mass index (BMI), highlighting widespread proteome changes and causal relationships between BMI and specific proteins.
format article
author Shaza B. Zaghlool
Sapna Sharma
Megan Molnar
Pamela R. Matías-García
Mohamed A. Elhadad
Melanie Waldenberger
Annette Peters
Wolfgang Rathmann
Johannes Graumann
Christian Gieger
Harald Grallert
Karsten Suhre
author_facet Shaza B. Zaghlool
Sapna Sharma
Megan Molnar
Pamela R. Matías-García
Mohamed A. Elhadad
Melanie Waldenberger
Annette Peters
Wolfgang Rathmann
Johannes Graumann
Christian Gieger
Harald Grallert
Karsten Suhre
author_sort Shaza B. Zaghlool
title Revealing the role of the human blood plasma proteome in obesity using genetic drivers
title_short Revealing the role of the human blood plasma proteome in obesity using genetic drivers
title_full Revealing the role of the human blood plasma proteome in obesity using genetic drivers
title_fullStr Revealing the role of the human blood plasma proteome in obesity using genetic drivers
title_full_unstemmed Revealing the role of the human blood plasma proteome in obesity using genetic drivers
title_sort revealing the role of the human blood plasma proteome in obesity using genetic drivers
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/0afbd25a06e148d5998f75500854222f
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AT meganmolnar revealingtheroleofthehumanbloodplasmaproteomeinobesityusinggeneticdrivers
AT pamelarmatiasgarcia revealingtheroleofthehumanbloodplasmaproteomeinobesityusinggeneticdrivers
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