Comprehensive assessment of TP53 loss of function using multiple combinatorial mutagenesis libraries

Abstract The diagnosis of somatic and germline TP53 mutations in human tumors or in individuals prone to various types of cancer has now reached the clinic. To increase the accuracy of the prediction of TP53 variant pathogenicity, we gathered functional data from three independent large-scale satura...

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Autores principales: Vincent Carbonnier, Bernard Leroy, Shai Rosenberg, Thierry Soussi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/0b0146cc59364ff9b0de255c6286014d
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