A simple reduction-sensitive micelles co-delivery of paclitaxel and dasatinib to overcome tumor multidrug resistance

Jun Li,1,* Ruitong Xu,2,* Xiao Lu,3 Jing He,1 Shidai Jin1 1Department of Medical Oncology, 2Department of General Practice, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 3Department of Medical Oncology, Changshu No 1 People’s Hospital, Changshu, People’...

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Autores principales:	Li J, Xu R, Lu X, He J, Jin S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	redox-responsive overcoming multidrug resistant co-delivery paclitaxel dasatinib Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0b02a4d17cff461d87d939675c13d9eb
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spelling	oai:doaj.org-article:0b02a4d17cff461d87d939675c13d9eb2021-12-02T06:33:30ZA simple reduction-sensitive micelles co-delivery of paclitaxel and dasatinib to overcome tumor multidrug resistance1178-2013https://doaj.org/article/0b02a4d17cff461d87d939675c13d9eb2017-11-01T00:00:00Zhttps://www.dovepress.com/a-simple-reduction-sensitive-micelles-co-delivery-of-paclitaxel-and-da-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jun Li,1,* Ruitong Xu,2,* Xiao Lu,3 Jing He,1 Shidai Jin1 1Department of Medical Oncology, 2Department of General Practice, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 3Department of Medical Oncology, Changshu No 1 People’s Hospital, Changshu, People’s Republic of China *These authors contributed equally to this work Abstract: Multidrug resistance (MDR) is one of the major obstacles in successful chemotherapy. The combination of chemotherapy drugs and multidrug-resistant reversing agents for treating MDR tumor is a good strategy to overcome MDR. In this work, we prepared the simple redox-responsive micelles based on mPEG-SS-C18 as a co-delivery system to load the paclitaxel (PTX) and dasatinib (DAS) for treatment of MCF-7/ADR cells. The co-loaded micelles had a good dispersity and a spherical shape with a uniform size distribution, and they could quickly disassemble and rapidly release drugs under the reduction environment. Compared with MCF-7 cells, the DAS and PTX co-loaded redox-sensitive micelle (SS-PDNPs) showed stronger cytotoxicity and a more improving intracellular drug concentration than other drug formulations in MCF-7/ADR cells. In summary, the results suggested that the simple co-delivery micelles of PTX and DAS possessed significant potential to overcome drug resistance in cancer therapy. Keywords: redox responsive, overcoming multidrug resistant, co-delivery, paclitaxel, dasatinib Li JXu RLu XHe JJin SDove Medical Pressarticleredox-responsiveovercoming multidrug resistantco-deliverypaclitaxeldasatinibMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 8043-8056 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	redox-responsive overcoming multidrug resistant co-delivery paclitaxel dasatinib Medicine (General) R5-920
spellingShingle	redox-responsive overcoming multidrug resistant co-delivery paclitaxel dasatinib Medicine (General) R5-920 Li J Xu R Lu X He J Jin S A simple reduction-sensitive micelles co-delivery of paclitaxel and dasatinib to overcome tumor multidrug resistance
description	Jun Li,1,* Ruitong Xu,2,* Xiao Lu,3 Jing He,1 Shidai Jin1 1Department of Medical Oncology, 2Department of General Practice, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 3Department of Medical Oncology, Changshu No 1 People’s Hospital, Changshu, People’s Republic of China *These authors contributed equally to this work Abstract: Multidrug resistance (MDR) is one of the major obstacles in successful chemotherapy. The combination of chemotherapy drugs and multidrug-resistant reversing agents for treating MDR tumor is a good strategy to overcome MDR. In this work, we prepared the simple redox-responsive micelles based on mPEG-SS-C18 as a co-delivery system to load the paclitaxel (PTX) and dasatinib (DAS) for treatment of MCF-7/ADR cells. The co-loaded micelles had a good dispersity and a spherical shape with a uniform size distribution, and they could quickly disassemble and rapidly release drugs under the reduction environment. Compared with MCF-7 cells, the DAS and PTX co-loaded redox-sensitive micelle (SS-PDNPs) showed stronger cytotoxicity and a more improving intracellular drug concentration than other drug formulations in MCF-7/ADR cells. In summary, the results suggested that the simple co-delivery micelles of PTX and DAS possessed significant potential to overcome drug resistance in cancer therapy. Keywords: redox responsive, overcoming multidrug resistant, co-delivery, paclitaxel, dasatinib
format	article
author	Li J Xu R Lu X He J Jin S
author_facet	Li J Xu R Lu X He J Jin S
author_sort	Li J
title	A simple reduction-sensitive micelles co-delivery of paclitaxel and dasatinib to overcome tumor multidrug resistance
title_short	A simple reduction-sensitive micelles co-delivery of paclitaxel and dasatinib to overcome tumor multidrug resistance
title_full	A simple reduction-sensitive micelles co-delivery of paclitaxel and dasatinib to overcome tumor multidrug resistance
title_fullStr	A simple reduction-sensitive micelles co-delivery of paclitaxel and dasatinib to overcome tumor multidrug resistance
title_full_unstemmed	A simple reduction-sensitive micelles co-delivery of paclitaxel and dasatinib to overcome tumor multidrug resistance
title_sort	simple reduction-sensitive micelles co-delivery of paclitaxel and dasatinib to overcome tumor multidrug resistance
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/0b02a4d17cff461d87d939675c13d9eb
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A simple reduction-sensitive micelles co-delivery of paclitaxel and dasatinib to overcome tumor multidrug resistance

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