Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration

A locus on chromosome 1 encompassing the CFHR genes is highly associated with AMD risk. Here, Cipriani and colleagues investigate the role of CFHR4, encoding FHR-4, and demonstrate a relationship between AMD risk, circulating FHR-4 levels and genetic variants at this locus.

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Autores principales:	Valentina Cipriani, Laura Lorés-Motta, Fan He, Dina Fathalla, Viranga Tilakaratna, Selina McHarg, Nadhim Bayatti, İlhan E. Acar, Carel B. Hoyng, Sascha Fauser, Anthony T. Moore, John R. W. Yates, Eiko K. de Jong, B. Paul Morgan, Anneke I. den Hollander, Paul N. Bishop, Simon J. Clark
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0b0f1261bc8d49669412ef574f2fe536
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spelling	oai:doaj.org-article:0b0f1261bc8d49669412ef574f2fe5362021-12-02T17:31:24ZIncreased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration10.1038/s41467-020-14499-32041-1723https://doaj.org/article/0b0f1261bc8d49669412ef574f2fe5362020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14499-3https://doaj.org/toc/2041-1723A locus on chromosome 1 encompassing the CFHR genes is highly associated with AMD risk. Here, Cipriani and colleagues investigate the role of CFHR4, encoding FHR-4, and demonstrate a relationship between AMD risk, circulating FHR-4 levels and genetic variants at this locus.Valentina CiprianiLaura Lorés-MottaFan HeDina FathallaViranga TilakaratnaSelina McHargNadhim Bayattiİlhan E. AcarCarel B. HoyngSascha FauserAnthony T. MooreJohn R. W. YatesEiko K. de JongB. Paul MorganAnneke I. den HollanderPaul N. BishopSimon J. ClarkNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Valentina Cipriani Laura Lorés-Motta Fan He Dina Fathalla Viranga Tilakaratna Selina McHarg Nadhim Bayatti İlhan E. Acar Carel B. Hoyng Sascha Fauser Anthony T. Moore John R. W. Yates Eiko K. de Jong B. Paul Morgan Anneke I. den Hollander Paul N. Bishop Simon J. Clark Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration
description	A locus on chromosome 1 encompassing the CFHR genes is highly associated with AMD risk. Here, Cipriani and colleagues investigate the role of CFHR4, encoding FHR-4, and demonstrate a relationship between AMD risk, circulating FHR-4 levels and genetic variants at this locus.
format	article
author	Valentina Cipriani Laura Lorés-Motta Fan He Dina Fathalla Viranga Tilakaratna Selina McHarg Nadhim Bayatti İlhan E. Acar Carel B. Hoyng Sascha Fauser Anthony T. Moore John R. W. Yates Eiko K. de Jong B. Paul Morgan Anneke I. den Hollander Paul N. Bishop Simon J. Clark
author_facet	Valentina Cipriani Laura Lorés-Motta Fan He Dina Fathalla Viranga Tilakaratna Selina McHarg Nadhim Bayatti İlhan E. Acar Carel B. Hoyng Sascha Fauser Anthony T. Moore John R. W. Yates Eiko K. de Jong B. Paul Morgan Anneke I. den Hollander Paul N. Bishop Simon J. Clark
author_sort	Valentina Cipriani
title	Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration
title_short	Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration
title_full	Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration
title_fullStr	Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration
title_full_unstemmed	Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration
title_sort	increased circulating levels of factor h-related protein 4 are strongly associated with age-related macular degeneration
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0b0f1261bc8d49669412ef574f2fe536
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Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration

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