Phage Therapy in the 21st Century: Is There Modern, Clinical Evidence of Phage-Mediated Efficacy?

Many bacteriophages are obligate killers of bacteria. That this property could be medically useful was first recognized over one hundred years ago, with 2021 being the 100-year anniversary of the first clinical phage therapy publication. Here we consider modern use of phages in clinical settings. Ou...

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Autores principales:	Stephen T. Abedon, Katarzyna M. Danis-Wlodarczyk, Diana R. Alves
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bacteriophage therapy case study clinical study combination therapy compassionate use expanded access Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/0b1036d02ab04e3fb3921a5501672852
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spelling	oai:doaj.org-article:0b1036d02ab04e3fb3921a55016728522021-11-25T18:39:47ZPhage Therapy in the 21st Century: Is There Modern, Clinical Evidence of Phage-Mediated Efficacy?10.3390/ph141111571424-8247https://doaj.org/article/0b1036d02ab04e3fb3921a55016728522021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1157https://doaj.org/toc/1424-8247Many bacteriophages are obligate killers of bacteria. That this property could be medically useful was first recognized over one hundred years ago, with 2021 being the 100-year anniversary of the first clinical phage therapy publication. Here we consider modern use of phages in clinical settings. Our aim is to answer one question: do phages serve as effective anti-bacterial infection agents when used clinically? An important emphasis of our analyses is on whether phage therapy-associated anti-bacterial infection efficacy can be reasonably distinguished from that associated with often coadministered antibiotics. We find that about half of 70 human phage treatment reports—published in English thus far in the 2000s—are suggestive of phage-mediated anti-bacterial infection efficacy. Two of these are randomized, double-blinded, infection-treatment studies while 14 of those studies, in our opinion, provide superior evidence of a phage role in observed treatment successes. Roughly three-quarters of these potentially phage-mediated outcomes are based on microbiological as well as clinical results, with the rest based on clinical success. Since many of these phage treatments are of infections for which antibiotic therapy had not been successful, their collective effectiveness is suggestive of a valid utility in employing phages to treat otherwise difficult-to-cure bacterial infections.Stephen T. AbedonKatarzyna M. Danis-WlodarczykDiana R. AlvesMDPI AGarticlebacteriophage therapycase studyclinical studycombination therapycompassionate useexpanded accessMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1157, p 1157 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bacteriophage therapy case study clinical study combination therapy compassionate use expanded access Medicine R Pharmacy and materia medica RS1-441
spellingShingle	bacteriophage therapy case study clinical study combination therapy compassionate use expanded access Medicine R Pharmacy and materia medica RS1-441 Stephen T. Abedon Katarzyna M. Danis-Wlodarczyk Diana R. Alves Phage Therapy in the 21st Century: Is There Modern, Clinical Evidence of Phage-Mediated Efficacy?
description	Many bacteriophages are obligate killers of bacteria. That this property could be medically useful was first recognized over one hundred years ago, with 2021 being the 100-year anniversary of the first clinical phage therapy publication. Here we consider modern use of phages in clinical settings. Our aim is to answer one question: do phages serve as effective anti-bacterial infection agents when used clinically? An important emphasis of our analyses is on whether phage therapy-associated anti-bacterial infection efficacy can be reasonably distinguished from that associated with often coadministered antibiotics. We find that about half of 70 human phage treatment reports—published in English thus far in the 2000s—are suggestive of phage-mediated anti-bacterial infection efficacy. Two of these are randomized, double-blinded, infection-treatment studies while 14 of those studies, in our opinion, provide superior evidence of a phage role in observed treatment successes. Roughly three-quarters of these potentially phage-mediated outcomes are based on microbiological as well as clinical results, with the rest based on clinical success. Since many of these phage treatments are of infections for which antibiotic therapy had not been successful, their collective effectiveness is suggestive of a valid utility in employing phages to treat otherwise difficult-to-cure bacterial infections.
format	article
author	Stephen T. Abedon Katarzyna M. Danis-Wlodarczyk Diana R. Alves
author_facet	Stephen T. Abedon Katarzyna M. Danis-Wlodarczyk Diana R. Alves
author_sort	Stephen T. Abedon
title	Phage Therapy in the 21st Century: Is There Modern, Clinical Evidence of Phage-Mediated Efficacy?
title_short	Phage Therapy in the 21st Century: Is There Modern, Clinical Evidence of Phage-Mediated Efficacy?
title_full	Phage Therapy in the 21st Century: Is There Modern, Clinical Evidence of Phage-Mediated Efficacy?
title_fullStr	Phage Therapy in the 21st Century: Is There Modern, Clinical Evidence of Phage-Mediated Efficacy?
title_full_unstemmed	Phage Therapy in the 21st Century: Is There Modern, Clinical Evidence of Phage-Mediated Efficacy?
title_sort	phage therapy in the 21st century: is there modern, clinical evidence of phage-mediated efficacy?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0b1036d02ab04e3fb3921a5501672852
work_keys_str_mv	AT stephentabedon phagetherapyinthe21stcenturyistheremodernclinicalevidenceofphagemediatedefficacy AT katarzynamdaniswlodarczyk phagetherapyinthe21stcenturyistheremodernclinicalevidenceofphagemediatedefficacy AT dianaralves phagetherapyinthe21stcenturyistheremodernclinicalevidenceofphagemediatedefficacy
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Phage Therapy in the 21st Century: Is There Modern, Clinical Evidence of Phage-Mediated Efficacy?

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