Mutational interactions define novel cancer subgroups

Tumour heterogeneity hinders translation of large-scale genomic data into the clinic. Here the authors develop a method for the stratification of cancer patients based on the molecular gene status, including genetic interactions, rather than clinico-histological data, and apply it to TCGA data for o...

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Autores principales:	Jack Kuipers, Thomas Thurnherr, Giusi Moffa, Polina Suter, Jonas Behr, Ryan Goosen, Gerhard Christofori, Niko Beerenwinkel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0b115bdf44cb494d927bace641aa4ed3
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spelling	oai:doaj.org-article:0b115bdf44cb494d927bace641aa4ed32021-12-02T14:40:05ZMutational interactions define novel cancer subgroups10.1038/s41467-018-06867-x2041-1723https://doaj.org/article/0b115bdf44cb494d927bace641aa4ed32018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06867-xhttps://doaj.org/toc/2041-1723Tumour heterogeneity hinders translation of large-scale genomic data into the clinic. Here the authors develop a method for the stratification of cancer patients based on the molecular gene status, including genetic interactions, rather than clinico-histological data, and apply it to TCGA data for over 8000 cases across 22 cancer types.Jack KuipersThomas ThurnherrGiusi MoffaPolina SuterJonas BehrRyan GoosenGerhard ChristoforiNiko BeerenwinkelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jack Kuipers Thomas Thurnherr Giusi Moffa Polina Suter Jonas Behr Ryan Goosen Gerhard Christofori Niko Beerenwinkel Mutational interactions define novel cancer subgroups
description	Tumour heterogeneity hinders translation of large-scale genomic data into the clinic. Here the authors develop a method for the stratification of cancer patients based on the molecular gene status, including genetic interactions, rather than clinico-histological data, and apply it to TCGA data for over 8000 cases across 22 cancer types.
format	article
author	Jack Kuipers Thomas Thurnherr Giusi Moffa Polina Suter Jonas Behr Ryan Goosen Gerhard Christofori Niko Beerenwinkel
author_facet	Jack Kuipers Thomas Thurnherr Giusi Moffa Polina Suter Jonas Behr Ryan Goosen Gerhard Christofori Niko Beerenwinkel
author_sort	Jack Kuipers
title	Mutational interactions define novel cancer subgroups
title_short	Mutational interactions define novel cancer subgroups
title_full	Mutational interactions define novel cancer subgroups
title_fullStr	Mutational interactions define novel cancer subgroups
title_full_unstemmed	Mutational interactions define novel cancer subgroups
title_sort	mutational interactions define novel cancer subgroups
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0b115bdf44cb494d927bace641aa4ed3
work_keys_str_mv	AT jackkuipers mutationalinteractionsdefinenovelcancersubgroups AT thomasthurnherr mutationalinteractionsdefinenovelcancersubgroups AT giusimoffa mutationalinteractionsdefinenovelcancersubgroups AT polinasuter mutationalinteractionsdefinenovelcancersubgroups AT jonasbehr mutationalinteractionsdefinenovelcancersubgroups AT ryangoosen mutationalinteractionsdefinenovelcancersubgroups AT gerhardchristofori mutationalinteractionsdefinenovelcancersubgroups AT nikobeerenwinkel mutationalinteractionsdefinenovelcancersubgroups
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Mutational interactions define novel cancer subgroups

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