Clinical dynamic visual acuity in patients with cerebellar ataxia and vestibulopathy.

Deterioration of dynamic visual acuity (DVA) as a result of impaired vestibulo-ocular reflex (VOR) has been well described in peripheral vestibulopathies, however, changes in DVA in patients with degenerative cerebellar ataxias (CA) and its relation to VOR impairment in these patients has not yet be...

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Autores principales:	Michaela Dankova, Jaroslav Jerabek, Dylan J Jester, Alena Zumrova, Jaroslava Paulasova Schwabova, Rudolf Cerny, Silvia Kmetonyova, Martin Vyhnalek
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0b133554cfca482f8dc74650f2d78cb6
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spelling	oai:doaj.org-article:0b133554cfca482f8dc74650f2d78cb62021-12-02T20:08:55ZClinical dynamic visual acuity in patients with cerebellar ataxia and vestibulopathy.1932-620310.1371/journal.pone.0255299https://doaj.org/article/0b133554cfca482f8dc74650f2d78cb62021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255299https://doaj.org/toc/1932-6203Deterioration of dynamic visual acuity (DVA) as a result of impaired vestibulo-ocular reflex (VOR) has been well described in peripheral vestibulopathies, however, changes in DVA in patients with degenerative cerebellar ataxias (CA) and its relation to VOR impairment in these patients has not yet been evaluated. Our aim was to assess the alterations of DVA in CA and to evaluate its relation to vestibular function. 32 patients with CA and 3 control groups: 13 patients with unilateral and 13 with bilateral vestibulopathy and 21 age matched healthy volunteers were examined by clinical DVA test, VOR was assessed by video Head Impulse Test and caloric irrigation. The severity of ataxia in CA was assessed by Scale for the assessment and rating of ataxia (SARA). Relationship between DVA and vestibular function in CA patients was examined by linear regressions. DVA impairment was highly prevalent in CA patients (84%) and its severity did not differ between CA and bilateral vestibulopathy patients. The severity of DVA impairment in CA was linked mainly to VOR impairment and only marginally to the degree of ataxia. However, DVA impairment was present also in CA patients without significant vestibular lesion showing that central mechanisms such as impairment of central adaptation of VOR are involved. We suggest that the evaluation of DVA should be a standard part of clinical evaluation in patients with progressive CA, as this information can help to target vestibular and oculomotor rehabilitation.Michaela DankovaJaroslav JerabekDylan J JesterAlena ZumrovaJaroslava Paulasova SchwabovaRudolf CernySilvia KmetonyovaMartin VyhnalekPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0255299 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michaela Dankova Jaroslav Jerabek Dylan J Jester Alena Zumrova Jaroslava Paulasova Schwabova Rudolf Cerny Silvia Kmetonyova Martin Vyhnalek Clinical dynamic visual acuity in patients with cerebellar ataxia and vestibulopathy.
description	Deterioration of dynamic visual acuity (DVA) as a result of impaired vestibulo-ocular reflex (VOR) has been well described in peripheral vestibulopathies, however, changes in DVA in patients with degenerative cerebellar ataxias (CA) and its relation to VOR impairment in these patients has not yet been evaluated. Our aim was to assess the alterations of DVA in CA and to evaluate its relation to vestibular function. 32 patients with CA and 3 control groups: 13 patients with unilateral and 13 with bilateral vestibulopathy and 21 age matched healthy volunteers were examined by clinical DVA test, VOR was assessed by video Head Impulse Test and caloric irrigation. The severity of ataxia in CA was assessed by Scale for the assessment and rating of ataxia (SARA). Relationship between DVA and vestibular function in CA patients was examined by linear regressions. DVA impairment was highly prevalent in CA patients (84%) and its severity did not differ between CA and bilateral vestibulopathy patients. The severity of DVA impairment in CA was linked mainly to VOR impairment and only marginally to the degree of ataxia. However, DVA impairment was present also in CA patients without significant vestibular lesion showing that central mechanisms such as impairment of central adaptation of VOR are involved. We suggest that the evaluation of DVA should be a standard part of clinical evaluation in patients with progressive CA, as this information can help to target vestibular and oculomotor rehabilitation.
format	article
author	Michaela Dankova Jaroslav Jerabek Dylan J Jester Alena Zumrova Jaroslava Paulasova Schwabova Rudolf Cerny Silvia Kmetonyova Martin Vyhnalek
author_facet	Michaela Dankova Jaroslav Jerabek Dylan J Jester Alena Zumrova Jaroslava Paulasova Schwabova Rudolf Cerny Silvia Kmetonyova Martin Vyhnalek
author_sort	Michaela Dankova
title	Clinical dynamic visual acuity in patients with cerebellar ataxia and vestibulopathy.
title_short	Clinical dynamic visual acuity in patients with cerebellar ataxia and vestibulopathy.
title_full	Clinical dynamic visual acuity in patients with cerebellar ataxia and vestibulopathy.
title_fullStr	Clinical dynamic visual acuity in patients with cerebellar ataxia and vestibulopathy.
title_full_unstemmed	Clinical dynamic visual acuity in patients with cerebellar ataxia and vestibulopathy.
title_sort	clinical dynamic visual acuity in patients with cerebellar ataxia and vestibulopathy.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0b133554cfca482f8dc74650f2d78cb6
work_keys_str_mv	AT michaeladankova clinicaldynamicvisualacuityinpatientswithcerebellarataxiaandvestibulopathy AT jaroslavjerabek clinicaldynamicvisualacuityinpatientswithcerebellarataxiaandvestibulopathy AT dylanjjester clinicaldynamicvisualacuityinpatientswithcerebellarataxiaandvestibulopathy AT alenazumrova clinicaldynamicvisualacuityinpatientswithcerebellarataxiaandvestibulopathy AT jaroslavapaulasovaschwabova clinicaldynamicvisualacuityinpatientswithcerebellarataxiaandvestibulopathy AT rudolfcerny clinicaldynamicvisualacuityinpatientswithcerebellarataxiaandvestibulopathy AT silviakmetonyova clinicaldynamicvisualacuityinpatientswithcerebellarataxiaandvestibulopathy AT martinvyhnalek clinicaldynamicvisualacuityinpatientswithcerebellarataxiaandvestibulopathy
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Clinical dynamic visual acuity in patients with cerebellar ataxia and vestibulopathy.

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