Fighting Antibiotic-Resistant <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> with “Sweet” Immune Targets

ABSTRACT Antibiotics and vaccines have greatly impacted human health in the last century by dramatically reducing the morbidity and mortality associated with infectious diseases. The recent challenge posed by the emergence of multidrug-resistant bacteria could possibly be addressed by novel immune p...

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Autores principales:	Roberto Adamo, Immaculada Margarit
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	antimicrobial resistance capsular polysaccharide immune therapy Klebsiella pneumoniae vaccines Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/0b13e1d28fa5457a9e635c095ca9595a
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spelling	oai:doaj.org-article:0b13e1d28fa5457a9e635c095ca9595a2021-11-15T16:00:27ZFighting Antibiotic-Resistant <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> with “Sweet” Immune Targets10.1128/mBio.00874-182150-7511https://doaj.org/article/0b13e1d28fa5457a9e635c095ca9595a2018-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00874-18https://doaj.org/toc/2150-7511ABSTRACT Antibiotics and vaccines have greatly impacted human health in the last century by dramatically reducing the morbidity and mortality associated with infectious diseases. The recent challenge posed by the emergence of multidrug-resistant bacteria could possibly be addressed by novel immune prophylactic and therapeutic approaches. Among the newly threatening pathogens, Klebsiella pneumoniae is particularly worrisome in the nosocomial setting, and its surface polysaccharides are regarded as promising antigen candidates. The majority of Klebsiella carbapenem-resistant strains belong to the sequence type 158 (ST258) lineage, with two main clades expressing capsular polysaccharides CPS1 and CPS2. In a recent article, S. D. Kobayashi and colleagues (mBio 9:e00297-18, 2018, https://doi.org/10.1128/mBio.00297-18) show that CPS2-specific IgGs render ST258 clade 2 bacteria more sensitive to human serum and phagocytic killing. E. Diago-Navarro et al. (mBio 9:e00091-18, 2018, https://doi.org/10.1128/mBio.00091-18) generated two murine monoclonal antibodies recognizing distinct glycotopes of CPS2 that presented functional activity against multiple ST258 strains. These complementary studies represent a step toward the control of this dangerous pathogen.Roberto AdamoImmaculada MargaritAmerican Society for Microbiologyarticleantimicrobial resistancecapsular polysaccharideimmune therapyKlebsiella pneumoniaevaccinesMicrobiologyQR1-502ENmBio, Vol 9, Iss 3 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	antimicrobial resistance capsular polysaccharide immune therapy Klebsiella pneumoniae vaccines Microbiology QR1-502
spellingShingle	antimicrobial resistance capsular polysaccharide immune therapy Klebsiella pneumoniae vaccines Microbiology QR1-502 Roberto Adamo Immaculada Margarit Fighting Antibiotic-Resistant <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> with “Sweet” Immune Targets
description	ABSTRACT Antibiotics and vaccines have greatly impacted human health in the last century by dramatically reducing the morbidity and mortality associated with infectious diseases. The recent challenge posed by the emergence of multidrug-resistant bacteria could possibly be addressed by novel immune prophylactic and therapeutic approaches. Among the newly threatening pathogens, Klebsiella pneumoniae is particularly worrisome in the nosocomial setting, and its surface polysaccharides are regarded as promising antigen candidates. The majority of Klebsiella carbapenem-resistant strains belong to the sequence type 158 (ST258) lineage, with two main clades expressing capsular polysaccharides CPS1 and CPS2. In a recent article, S. D. Kobayashi and colleagues (mBio 9:e00297-18, 2018, https://doi.org/10.1128/mBio.00297-18) show that CPS2-specific IgGs render ST258 clade 2 bacteria more sensitive to human serum and phagocytic killing. E. Diago-Navarro et al. (mBio 9:e00091-18, 2018, https://doi.org/10.1128/mBio.00091-18) generated two murine monoclonal antibodies recognizing distinct glycotopes of CPS2 that presented functional activity against multiple ST258 strains. These complementary studies represent a step toward the control of this dangerous pathogen.
format	article
author	Roberto Adamo Immaculada Margarit
author_facet	Roberto Adamo Immaculada Margarit
author_sort	Roberto Adamo
title	Fighting Antibiotic-Resistant <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> with “Sweet” Immune Targets
title_short	Fighting Antibiotic-Resistant <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> with “Sweet” Immune Targets
title_full	Fighting Antibiotic-Resistant <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> with “Sweet” Immune Targets
title_fullStr	Fighting Antibiotic-Resistant <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> with “Sweet” Immune Targets
title_full_unstemmed	Fighting Antibiotic-Resistant <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> with “Sweet” Immune Targets
title_sort	fighting antibiotic-resistant <named-content content-type="genus-species">klebsiella pneumoniae</named-content> with “sweet” immune targets
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/0b13e1d28fa5457a9e635c095ca9595a
work_keys_str_mv	AT robertoadamo fightingantibioticresistantnamedcontentcontenttypegenusspeciesklebsiellapneumoniaenamedcontentwithsweetimmunetargets AT immaculadamargarit fightingantibioticresistantnamedcontentcontenttypegenusspeciesklebsiellapneumoniaenamedcontentwithsweetimmunetargets
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Fighting Antibiotic-Resistant <named-content content-type="genus-species">Klebsiella pneumoniae</named-content> with “Sweet” Immune Targets

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