A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum

A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum

Currently available platforms to study liver stage of Plasmodium species have limitations. Here, the authors show that primary human hepatocyte cultures in 384-well format support hypnozoite and other liver stage development and are suitable for drug and antibody screens.

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Autores principales: Alison Roth, Steven P. Maher, Amy J. Conway, Ratawan Ubalee, Victor Chaumeau, Chiara Andolina, Stephen A. Kaba, Amélie Vantaux, Malina A. Bakowski, Richard Thomson-Luque, Swamy Rakesh Adapa, Naresh Singh, Samantha J. Barnes, Caitlin A. Cooper, Mélanie Rouillier, Case W. McNamara, Sebastian A. Mikolajczak, Noah Sather, Benoît Witkowski, Brice Campo, Stefan H. I. Kappe, David E. Lanar, François Nosten, Silas Davidson, Rays H. Y. Jiang, Dennis E. Kyle, John H. Adams
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/0b14f6d533014ef091394f171d42ba23
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spelling oai:doaj.org-article:0b14f6d533014ef091394f171d42ba232021-12-02T14:40:04ZA comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum10.1038/s41467-018-04221-92041-1723https://doaj.org/article/0b14f6d533014ef091394f171d42ba232018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04221-9https://doaj.org/toc/2041-1723Currently available platforms to study liver stage of Plasmodium species have limitations. Here, the authors show that primary human hepatocyte cultures in 384-well format support hypnozoite and other liver stage development and are suitable for drug and antibody screens.Alison RothSteven P. MaherAmy J. ConwayRatawan UbaleeVictor ChaumeauChiara AndolinaStephen A. KabaAmélie VantauxMalina A. BakowskiRichard Thomson-LuqueSwamy Rakesh AdapaNaresh SinghSamantha J. BarnesCaitlin A. CooperMélanie RouillierCase W. McNamaraSebastian A. MikolajczakNoah SatherBenoît WitkowskiBrice CampoStefan H. I. KappeDavid E. LanarFrançois NostenSilas DavidsonRays H. Y. JiangDennis E. KyleJohn H. AdamsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Alison Roth
Steven P. Maher
Amy J. Conway
Ratawan Ubalee
Victor Chaumeau
Chiara Andolina
Stephen A. Kaba
Amélie Vantaux
Malina A. Bakowski
Richard Thomson-Luque
Swamy Rakesh Adapa
Naresh Singh
Samantha J. Barnes
Caitlin A. Cooper
Mélanie Rouillier
Case W. McNamara
Sebastian A. Mikolajczak
Noah Sather
Benoît Witkowski
Brice Campo
Stefan H. I. Kappe
David E. Lanar
François Nosten
Silas Davidson
Rays H. Y. Jiang
Dennis E. Kyle
John H. Adams
A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum
description Currently available platforms to study liver stage of Plasmodium species have limitations. Here, the authors show that primary human hepatocyte cultures in 384-well format support hypnozoite and other liver stage development and are suitable for drug and antibody screens.
format article
author Alison Roth
Steven P. Maher
Amy J. Conway
Ratawan Ubalee
Victor Chaumeau
Chiara Andolina
Stephen A. Kaba
Amélie Vantaux
Malina A. Bakowski
Richard Thomson-Luque
Swamy Rakesh Adapa
Naresh Singh
Samantha J. Barnes
Caitlin A. Cooper
Mélanie Rouillier
Case W. McNamara
Sebastian A. Mikolajczak
Noah Sather
Benoît Witkowski
Brice Campo
Stefan H. I. Kappe
David E. Lanar
François Nosten
Silas Davidson
Rays H. Y. Jiang
Dennis E. Kyle
John H. Adams
author_facet Alison Roth
Steven P. Maher
Amy J. Conway
Ratawan Ubalee
Victor Chaumeau
Chiara Andolina
Stephen A. Kaba
Amélie Vantaux
Malina A. Bakowski
Richard Thomson-Luque
Swamy Rakesh Adapa
Naresh Singh
Samantha J. Barnes
Caitlin A. Cooper
Mélanie Rouillier
Case W. McNamara
Sebastian A. Mikolajczak
Noah Sather
Benoît Witkowski
Brice Campo
Stefan H. I. Kappe
David E. Lanar
François Nosten
Silas Davidson
Rays H. Y. Jiang
Dennis E. Kyle
John H. Adams
author_sort Alison Roth
title A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum
title_short A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum
title_full A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum
title_fullStr A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum
title_full_unstemmed A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum
title_sort comprehensive model for assessment of liver stage therapies targeting plasmodium vivax and plasmodium falciparum
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/0b14f6d533014ef091394f171d42ba23
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