Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis

BMP promotes bone formation but its efficacy is limited in some patients. Here, the authors show that osteoporosis patients with a poor response to BMP have increased expression of Smurf1, which targets BMP effectors for degradation, and demonstrate that its chemical inhibition enhances BMP-mediated...

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Autores principales:	Chao Liang, Songlin Peng, Jie Li, Jun Lu, Daogang Guan, Feng Jiang, Cheng Lu, Fangfei Li, Xiaojuan He, Hailong Zhu, D. W. T. Au, Dazhi Yang, Bao-Ting Zhang, Aiping Lu, Ge Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0b158da3ebda4212a171a0e9badbc8f5
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spelling	oai:doaj.org-article:0b158da3ebda4212a171a0e9badbc8f52021-12-02T14:39:45ZInhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis10.1038/s41467-018-05974-z2041-1723https://doaj.org/article/0b158da3ebda4212a171a0e9badbc8f52018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05974-zhttps://doaj.org/toc/2041-1723BMP promotes bone formation but its efficacy is limited in some patients. Here, the authors show that osteoporosis patients with a poor response to BMP have increased expression of Smurf1, which targets BMP effectors for degradation, and demonstrate that its chemical inhibition enhances BMP-mediated bone formation in mice.Chao LiangSonglin PengJie LiJun LuDaogang GuanFeng JiangCheng LuFangfei LiXiaojuan HeHailong ZhuD. W. T. AuDazhi YangBao-Ting ZhangAiping LuGe ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chao Liang Songlin Peng Jie Li Jun Lu Daogang Guan Feng Jiang Cheng Lu Fangfei Li Xiaojuan He Hailong Zhu D. W. T. Au Dazhi Yang Bao-Ting Zhang Aiping Lu Ge Zhang Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis
description	BMP promotes bone formation but its efficacy is limited in some patients. Here, the authors show that osteoporosis patients with a poor response to BMP have increased expression of Smurf1, which targets BMP effectors for degradation, and demonstrate that its chemical inhibition enhances BMP-mediated bone formation in mice.
format	article
author	Chao Liang Songlin Peng Jie Li Jun Lu Daogang Guan Feng Jiang Cheng Lu Fangfei Li Xiaojuan He Hailong Zhu D. W. T. Au Dazhi Yang Bao-Ting Zhang Aiping Lu Ge Zhang
author_facet	Chao Liang Songlin Peng Jie Li Jun Lu Daogang Guan Feng Jiang Cheng Lu Fangfei Li Xiaojuan He Hailong Zhu D. W. T. Au Dazhi Yang Bao-Ting Zhang Aiping Lu Ge Zhang
author_sort	Chao Liang
title	Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis
title_short	Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis
title_full	Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis
title_fullStr	Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis
title_full_unstemmed	Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis
title_sort	inhibition of osteoblastic smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0b158da3ebda4212a171a0e9badbc8f5
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Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis

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