Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis

Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis

BMP promotes bone formation but its efficacy is limited in some patients. Here, the authors show that osteoporosis patients with a poor response to BMP have increased expression of Smurf1, which targets BMP effectors for degradation, and demonstrate that its chemical inhibition enhances BMP-mediated...

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Autores principales: Chao Liang, Songlin Peng, Jie Li, Jun Lu, Daogang Guan, Feng Jiang, Cheng Lu, Fangfei Li, Xiaojuan He, Hailong Zhu, D. W. T. Au, Dazhi Yang, Bao-Ting Zhang, Aiping Lu, Ge Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/0b158da3ebda4212a171a0e9badbc8f5
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