Assessing factors influencing communities' acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana.

<h4>Background</h4>Guyana is one of four countries in the Latin American Region where lymphatic filariasis (LF) remains endemic. In preparation for the introduction of a new triple drug therapy regimen (ivermectin, diethylcarbamazine, and albendazole (IDA)) in 2019, an acceptability stud...

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Autores principales:	Reza A Niles, Charles R Thickstun, Horace Cox, Daniel Dilliott, Clara R Burgert-Brucker, Emma M Harding-Esch, Nikita Clementson, Annastacia Sampson, Jean Seme Alexandre, Ana C Morice Trejos, Ronaldo G Carvalho Scholte, Alison Krentel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/0b1b563103284b228fb03e3eaf669527
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spelling	oai:doaj.org-article:0b1b563103284b228fb03e3eaf6695272021-12-02T20:24:05ZAssessing factors influencing communities' acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana.1935-27271935-273510.1371/journal.pntd.0009596https://doaj.org/article/0b1b563103284b228fb03e3eaf6695272021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009596https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Guyana is one of four countries in the Latin American Region where lymphatic filariasis (LF) remains endemic. In preparation for the introduction of a new triple drug therapy regimen (ivermectin, diethylcarbamazine, and albendazole (IDA)) in 2019, an acceptability study was embedded within sentinel site mapping in four regions to assess mass drug administration (MDA) coverage and compliance, acceptability, and perceptions about treatment and disease. The results from this survey would inform the rollout of IDA in Guyana in 2019.<h4>Methods</h4>Data collection for the study occurred in August 2019, using a validated questionnaire administered by trained enumerators. Across all regions, a total of 1,248 participants were sampled by the Filarial Mapping team. Four-hundred and fifty-one participants aged over 18 years were randomly selected for participation in an expanded acceptability questionnaire. All data were captured in Secure Data Kit (SDK).<h4>Results</h4>Acceptability was measured using a mean acceptability score. Unadjusted mean scores ranged from 24.6 to 29.3, with 22.5 as the threshold of acceptability. Regional variation occurred across many indicators of interest: self-rated understanding about LF, mechanisms of LF transmission, LF drug safety and history of treatment during MDA. Region IV (Georgetown) recorded higher knowledge about LF, but lower compliance and acceptability. Number of pills was not perceived as a concern.<h4>Conclusion</h4>Acceptability of MDA was good across all four regions under study. Results from this study set a baseline level for key indicators and acceptability, from which the acceptability of IDA can be measured. Regional variations across indicators suggest that localized approaches should be considered for social mobilization and MDA delivery to capture these contextual differences.Reza A NilesCharles R ThickstunHorace CoxDaniel DilliottClara R Burgert-BruckerEmma M Harding-EschNikita ClementsonAnnastacia SampsonJean Seme AlexandreAna C Morice TrejosRonaldo G Carvalho ScholteAlison KrentelPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009596 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Reza A Niles Charles R Thickstun Horace Cox Daniel Dilliott Clara R Burgert-Brucker Emma M Harding-Esch Nikita Clementson Annastacia Sampson Jean Seme Alexandre Ana C Morice Trejos Ronaldo G Carvalho Scholte Alison Krentel Assessing factors influencing communities' acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana.
description	<h4>Background</h4>Guyana is one of four countries in the Latin American Region where lymphatic filariasis (LF) remains endemic. In preparation for the introduction of a new triple drug therapy regimen (ivermectin, diethylcarbamazine, and albendazole (IDA)) in 2019, an acceptability study was embedded within sentinel site mapping in four regions to assess mass drug administration (MDA) coverage and compliance, acceptability, and perceptions about treatment and disease. The results from this survey would inform the rollout of IDA in Guyana in 2019.<h4>Methods</h4>Data collection for the study occurred in August 2019, using a validated questionnaire administered by trained enumerators. Across all regions, a total of 1,248 participants were sampled by the Filarial Mapping team. Four-hundred and fifty-one participants aged over 18 years were randomly selected for participation in an expanded acceptability questionnaire. All data were captured in Secure Data Kit (SDK).<h4>Results</h4>Acceptability was measured using a mean acceptability score. Unadjusted mean scores ranged from 24.6 to 29.3, with 22.5 as the threshold of acceptability. Regional variation occurred across many indicators of interest: self-rated understanding about LF, mechanisms of LF transmission, LF drug safety and history of treatment during MDA. Region IV (Georgetown) recorded higher knowledge about LF, but lower compliance and acceptability. Number of pills was not perceived as a concern.<h4>Conclusion</h4>Acceptability of MDA was good across all four regions under study. Results from this study set a baseline level for key indicators and acceptability, from which the acceptability of IDA can be measured. Regional variations across indicators suggest that localized approaches should be considered for social mobilization and MDA delivery to capture these contextual differences.
format	article
author	Reza A Niles Charles R Thickstun Horace Cox Daniel Dilliott Clara R Burgert-Brucker Emma M Harding-Esch Nikita Clementson Annastacia Sampson Jean Seme Alexandre Ana C Morice Trejos Ronaldo G Carvalho Scholte Alison Krentel
author_facet	Reza A Niles Charles R Thickstun Horace Cox Daniel Dilliott Clara R Burgert-Brucker Emma M Harding-Esch Nikita Clementson Annastacia Sampson Jean Seme Alexandre Ana C Morice Trejos Ronaldo G Carvalho Scholte Alison Krentel
author_sort	Reza A Niles
title	Assessing factors influencing communities' acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana.
title_short	Assessing factors influencing communities' acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana.
title_full	Assessing factors influencing communities' acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana.
title_fullStr	Assessing factors influencing communities' acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana.
title_full_unstemmed	Assessing factors influencing communities' acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana.
title_sort	assessing factors influencing communities' acceptability of mass drug administration for the elimination of lymphatic filariasis in guyana.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0b1b563103284b228fb03e3eaf669527
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Assessing factors influencing communities' acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana.

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