Leptin and advanced glycation end products receptor (RAGE) in tuberculosis patients.

<h4>Introduction</h4>The pathogenesis of consumptive syndrome of tuberculosis (TB) is largely unknown. Leptin concentrations may be high because of the host's inflammatory response, contributing to weight loss in patients with TB. The receptor for advanced glycation end products (RA...

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Autores principales:	Tássia Kirchmann Lazzari, Erika Cavalheiro, Sandra Eugênia Coutinho, Lívia Fontes da Silva, Denise Rossato Silva
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0b1cb9bd898d48028b011cdf8eadaa41
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spelling	oai:doaj.org-article:0b1cb9bd898d48028b011cdf8eadaa412021-12-02T20:15:38ZLeptin and advanced glycation end products receptor (RAGE) in tuberculosis patients.1932-620310.1371/journal.pone.0254198https://doaj.org/article/0b1cb9bd898d48028b011cdf8eadaa412021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254198https://doaj.org/toc/1932-6203<h4>Introduction</h4>The pathogenesis of consumptive syndrome of tuberculosis (TB) is largely unknown. Leptin concentrations may be high because of the host's inflammatory response, contributing to weight loss in patients with TB. The receptor for advanced glycation end products (RAGE) is also associated with weight loss in patients with TB and is related to enhanced mortality. The objective of this study was to evaluate the association between leptin and AGE/RAGE.<h4>Methods</h4>Case-control study. Leptin, AGE (carboxymethyl lysine, CML) and soluble RAGE (sRAGE) were measured from blood samples by ELISA.<h4>Results</h4>We included in the study 34 patients with TB and 34 controls. We found an inverse correlation between serum leptin levels and sRAGE, only in cases (r = -0.609, p < 0.0001). sRAGE levels were lower in patients with TB who died as compared with patients who survive (21.90 ± 4.24 pg/mL vs 66.14 ± 29.49 pg/mL; p = 0.045). Leptin levels were higher in patients with TB who died as compared with patients who survive (14.11 [7.48-14.11] ng/mL vs 3.08 [0.54-6.34] ng/mL; p = 0.028).<h4>Conclusions</h4>We identified lower sRAGE levels and higher leptin levels in patients with TB who died as compared with patients who survive. In addition, an inverse and significant correlation between serum leptin and sRAGE levels was demonstrated. Future studies, with a larger sample size and in different settings, including not only hospitalized patients, are needed to confirm these findings.Tássia Kirchmann LazzariErika CavalheiroSandra Eugênia CoutinhoLívia Fontes da SilvaDenise Rossato SilvaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254198 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tássia Kirchmann Lazzari Erika Cavalheiro Sandra Eugênia Coutinho Lívia Fontes da Silva Denise Rossato Silva Leptin and advanced glycation end products receptor (RAGE) in tuberculosis patients.
description	<h4>Introduction</h4>The pathogenesis of consumptive syndrome of tuberculosis (TB) is largely unknown. Leptin concentrations may be high because of the host's inflammatory response, contributing to weight loss in patients with TB. The receptor for advanced glycation end products (RAGE) is also associated with weight loss in patients with TB and is related to enhanced mortality. The objective of this study was to evaluate the association between leptin and AGE/RAGE.<h4>Methods</h4>Case-control study. Leptin, AGE (carboxymethyl lysine, CML) and soluble RAGE (sRAGE) were measured from blood samples by ELISA.<h4>Results</h4>We included in the study 34 patients with TB and 34 controls. We found an inverse correlation between serum leptin levels and sRAGE, only in cases (r = -0.609, p < 0.0001). sRAGE levels were lower in patients with TB who died as compared with patients who survive (21.90 ± 4.24 pg/mL vs 66.14 ± 29.49 pg/mL; p = 0.045). Leptin levels were higher in patients with TB who died as compared with patients who survive (14.11 [7.48-14.11] ng/mL vs 3.08 [0.54-6.34] ng/mL; p = 0.028).<h4>Conclusions</h4>We identified lower sRAGE levels and higher leptin levels in patients with TB who died as compared with patients who survive. In addition, an inverse and significant correlation between serum leptin and sRAGE levels was demonstrated. Future studies, with a larger sample size and in different settings, including not only hospitalized patients, are needed to confirm these findings.
format	article
author	Tássia Kirchmann Lazzari Erika Cavalheiro Sandra Eugênia Coutinho Lívia Fontes da Silva Denise Rossato Silva
author_facet	Tássia Kirchmann Lazzari Erika Cavalheiro Sandra Eugênia Coutinho Lívia Fontes da Silva Denise Rossato Silva
author_sort	Tássia Kirchmann Lazzari
title	Leptin and advanced glycation end products receptor (RAGE) in tuberculosis patients.
title_short	Leptin and advanced glycation end products receptor (RAGE) in tuberculosis patients.
title_full	Leptin and advanced glycation end products receptor (RAGE) in tuberculosis patients.
title_fullStr	Leptin and advanced glycation end products receptor (RAGE) in tuberculosis patients.
title_full_unstemmed	Leptin and advanced glycation end products receptor (RAGE) in tuberculosis patients.
title_sort	leptin and advanced glycation end products receptor (rage) in tuberculosis patients.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0b1cb9bd898d48028b011cdf8eadaa41
work_keys_str_mv	AT tassiakirchmannlazzari leptinandadvancedglycationendproductsreceptorrageintuberculosispatients AT erikacavalheiro leptinandadvancedglycationendproductsreceptorrageintuberculosispatients AT sandraeugeniacoutinho leptinandadvancedglycationendproductsreceptorrageintuberculosispatients AT liviafontesdasilva leptinandadvancedglycationendproductsreceptorrageintuberculosispatients AT deniserossatosilva leptinandadvancedglycationendproductsreceptorrageintuberculosispatients
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Leptin and advanced glycation end products receptor (RAGE) in tuberculosis patients.

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