Natural material-decorated mesoporous silica nanoparticle container for multifunctional membrane-controlled targeted drug delivery

Yan Hu,1 Lei Ke,2 Hao Chen,1 Ma Zhuo,1 Xinzhou Yang,1 Dan Zhao,1 Suying Zeng,1 Xincai Xiao1 1Department of Pharmaceutics, School of Pharmaceutical Science, South-Central University for Nationalities, 2Department of Medicinal Chemistry, School of Pharmacy, Tongji Medical College, Huazhong University...

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Autores principales:	Hu Y, Ke L, Chen H, Zhuo M, Yang XZ, Zhao D, Zeng SY, Xiao XC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	multifunctional membrane-controlled natural materials mesoporous silica nanoparticles targeted drug delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0b2a46a2f4a14bc19838c6b14766ca9f
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spelling	oai:doaj.org-article:0b2a46a2f4a14bc19838c6b14766ca9f2021-12-02T07:13:43ZNatural material-decorated mesoporous silica nanoparticle container for multifunctional membrane-controlled targeted drug delivery1178-2013https://doaj.org/article/0b2a46a2f4a14bc19838c6b14766ca9f2017-11-01T00:00:00Zhttps://www.dovepress.com/natural-material-decorated-mesoporous-silica-nanoparticle-container-fo-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yan Hu,1 Lei Ke,2 Hao Chen,1 Ma Zhuo,1 Xinzhou Yang,1 Dan Zhao,1 Suying Zeng,1 Xincai Xiao1 1Department of Pharmaceutics, School of Pharmaceutical Science, South-Central University for Nationalities, 2Department of Medicinal Chemistry, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China Abstract: To avoid the side effects caused by nonspecific targeting, premature release, weak selectivity, and poor therapeutic efficacy of current nanoparticle-based systems used for drug delivery, we fabricated natural material-decorated nanoparticles as a multifunctional, membrane-controlled targeted drug delivery system. The nanocomposite material coated with a membrane was biocompatible and integrated both specific tumor targeting and responsiveness to stimulation, which improved transmission efficacy and controlled drug release. Mesoporous silica nanoparticles (MSNs), which are known for their biocompatibility and high drug-loading capacity, were selected as a model drug container and carrier. The membrane was established by the polyelectrolyte composite method from chitosan (CS) which was sensitive to the acidic tumor microenvironment, folic acid-modified CS which recognizes the folate receptor expressed on the tumor cell surface, and a CD44 receptor-targeted polysaccharide hyaluronic acid. We characterized the structure of the nanocomposite as well as the drug release behavior under the control of the pH-sensitive membrane switch and evaluated the antitumor efficacy of the system in vitro. Our results provide a basis for the design and fabrication of novel membrane-controlled nanoparticles with improved tumor-targeting therapy. Keywords: multifunctional, membrane-controlled, natural materials, mesoporous silica nanoparticles, targeted drug deliveryHu YKe LChen HZhuo MYang XZZhao DZeng SYXiao XCDove Medical Pressarticlemultifunctionalmembrane-controllednatural materialsmesoporous silica nanoparticlestargeted drug deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 8411-8426 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	multifunctional membrane-controlled natural materials mesoporous silica nanoparticles targeted drug delivery Medicine (General) R5-920
spellingShingle	multifunctional membrane-controlled natural materials mesoporous silica nanoparticles targeted drug delivery Medicine (General) R5-920 Hu Y Ke L Chen H Zhuo M Yang XZ Zhao D Zeng SY Xiao XC Natural material-decorated mesoporous silica nanoparticle container for multifunctional membrane-controlled targeted drug delivery
description	Yan Hu,1 Lei Ke,2 Hao Chen,1 Ma Zhuo,1 Xinzhou Yang,1 Dan Zhao,1 Suying Zeng,1 Xincai Xiao1 1Department of Pharmaceutics, School of Pharmaceutical Science, South-Central University for Nationalities, 2Department of Medicinal Chemistry, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China Abstract: To avoid the side effects caused by nonspecific targeting, premature release, weak selectivity, and poor therapeutic efficacy of current nanoparticle-based systems used for drug delivery, we fabricated natural material-decorated nanoparticles as a multifunctional, membrane-controlled targeted drug delivery system. The nanocomposite material coated with a membrane was biocompatible and integrated both specific tumor targeting and responsiveness to stimulation, which improved transmission efficacy and controlled drug release. Mesoporous silica nanoparticles (MSNs), which are known for their biocompatibility and high drug-loading capacity, were selected as a model drug container and carrier. The membrane was established by the polyelectrolyte composite method from chitosan (CS) which was sensitive to the acidic tumor microenvironment, folic acid-modified CS which recognizes the folate receptor expressed on the tumor cell surface, and a CD44 receptor-targeted polysaccharide hyaluronic acid. We characterized the structure of the nanocomposite as well as the drug release behavior under the control of the pH-sensitive membrane switch and evaluated the antitumor efficacy of the system in vitro. Our results provide a basis for the design and fabrication of novel membrane-controlled nanoparticles with improved tumor-targeting therapy. Keywords: multifunctional, membrane-controlled, natural materials, mesoporous silica nanoparticles, targeted drug delivery
format	article
author	Hu Y Ke L Chen H Zhuo M Yang XZ Zhao D Zeng SY Xiao XC
author_facet	Hu Y Ke L Chen H Zhuo M Yang XZ Zhao D Zeng SY Xiao XC
author_sort	Hu Y
title	Natural material-decorated mesoporous silica nanoparticle container for multifunctional membrane-controlled targeted drug delivery
title_short	Natural material-decorated mesoporous silica nanoparticle container for multifunctional membrane-controlled targeted drug delivery
title_full	Natural material-decorated mesoporous silica nanoparticle container for multifunctional membrane-controlled targeted drug delivery
title_fullStr	Natural material-decorated mesoporous silica nanoparticle container for multifunctional membrane-controlled targeted drug delivery
title_full_unstemmed	Natural material-decorated mesoporous silica nanoparticle container for multifunctional membrane-controlled targeted drug delivery
title_sort	natural material-decorated mesoporous silica nanoparticle container for multifunctional membrane-controlled targeted drug delivery
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/0b2a46a2f4a14bc19838c6b14766ca9f
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Natural material-decorated mesoporous silica nanoparticle container for multifunctional membrane-controlled targeted drug delivery

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