ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity

Endoplasmic-reticulum associated degradation (ERAD) regulates protein homeostasis. Here the authors identify an ERAD component membralin, and show that it interacts with a member of the γ-secretase complex to regulate β-amyloid (Aβ) pathology and memory deficits in an Alzheimer’s disease model.

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Autores principales:	Bing Zhu, LuLin Jiang, Timothy Huang, Yingjun Zhao, Tongfei Liu, Yongwang Zhong, Xiaoguang Li, Alexandre Campos, Kenneth Pomeroy, Eliezer Masliah, Dongxian Zhang, Huaxi Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0b2b5777bfa844f4855e75bfcbd6c2fd
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spelling	oai:doaj.org-article:0b2b5777bfa844f4855e75bfcbd6c2fd2021-12-02T17:06:17ZER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity10.1038/s41467-017-01799-42041-1723https://doaj.org/article/0b2b5777bfa844f4855e75bfcbd6c2fd2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01799-4https://doaj.org/toc/2041-1723Endoplasmic-reticulum associated degradation (ERAD) regulates protein homeostasis. Here the authors identify an ERAD component membralin, and show that it interacts with a member of the γ-secretase complex to regulate β-amyloid (Aβ) pathology and memory deficits in an Alzheimer’s disease model.Bing ZhuLuLin JiangTimothy HuangYingjun ZhaoTongfei LiuYongwang ZhongXiaoguang LiAlexandre CamposKenneth PomeroyEliezer MasliahDongxian ZhangHuaxi XuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bing Zhu LuLin Jiang Timothy Huang Yingjun Zhao Tongfei Liu Yongwang Zhong Xiaoguang Li Alexandre Campos Kenneth Pomeroy Eliezer Masliah Dongxian Zhang Huaxi Xu ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity
description	Endoplasmic-reticulum associated degradation (ERAD) regulates protein homeostasis. Here the authors identify an ERAD component membralin, and show that it interacts with a member of the γ-secretase complex to regulate β-amyloid (Aβ) pathology and memory deficits in an Alzheimer’s disease model.
format	article
author	Bing Zhu LuLin Jiang Timothy Huang Yingjun Zhao Tongfei Liu Yongwang Zhong Xiaoguang Li Alexandre Campos Kenneth Pomeroy Eliezer Masliah Dongxian Zhang Huaxi Xu
author_facet	Bing Zhu LuLin Jiang Timothy Huang Yingjun Zhao Tongfei Liu Yongwang Zhong Xiaoguang Li Alexandre Campos Kenneth Pomeroy Eliezer Masliah Dongxian Zhang Huaxi Xu
author_sort	Bing Zhu
title	ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity
title_short	ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity
title_full	ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity
title_fullStr	ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity
title_full_unstemmed	ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity
title_sort	er-associated degradation regulates alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0b2b5777bfa844f4855e75bfcbd6c2fd
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ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity

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