ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity

ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity

Endoplasmic-reticulum associated degradation (ERAD) regulates protein homeostasis. Here the authors identify an ERAD component membralin, and show that it interacts with a member of the γ-secretase complex to regulate β-amyloid (Aβ) pathology and memory deficits in an Alzheimer’s disease model.

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Detalles Bibliográficos
Autores principales: Bing Zhu, LuLin Jiang, Timothy Huang, Yingjun Zhao, Tongfei Liu, Yongwang Zhong, Xiaoguang Li, Alexandre Campos, Kenneth Pomeroy, Eliezer Masliah, Dongxian Zhang, Huaxi Xu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/0b2b5777bfa844f4855e75bfcbd6c2fd
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