Development and Validation of Non simultaneous Retinal Image Acquisition–Based Retinal Oximeter

Abstract The purpose of this study was to develop and validate a tool for the measurement of retinal oxygen saturation using a conventional fundus camera–based nonsimultaneous imaging technique. Retinal oximetry setup comprising a conventional Zeiss FF450IR fundus camera, dual wavelength band-pass f...

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Autores principales:	Sumeer Singh, Gunasekaran Velu, Rajiv Raman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0b2e94a294814f1cb3ecbdaaa568276f
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spelling	oai:doaj.org-article:0b2e94a294814f1cb3ecbdaaa568276f2021-12-02T15:05:54ZDevelopment and Validation of Non simultaneous Retinal Image Acquisition–Based Retinal Oximeter10.1038/s41598-017-04085-x2045-2322https://doaj.org/article/0b2e94a294814f1cb3ecbdaaa568276f2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04085-xhttps://doaj.org/toc/2045-2322Abstract The purpose of this study was to develop and validate a tool for the measurement of retinal oxygen saturation using a conventional fundus camera–based nonsimultaneous imaging technique. Retinal oximetry setup comprising a conventional Zeiss FF450IR fundus camera, dual wavelength band-pass filters of wavelengths 570 and 600 nm were used. Image analysis was performed using MATLAB R2013b. All the study participants underwent comprehensive eye examination, fundus examination, complete hemogram analysis, and evaluation of systemic hemodynamics. Fundus images were captured by a nonsimultaneous retinal oximetry. A total of 45 subjects were included in the analysis. Median age of the subjects was 21 years ranging from 19 to 34 years. The median retinal arteriolar and venular oxygen saturation was 94.7% and 55.8%. Comparison of retinal oxygen saturation between three visits showed no statistically significant difference for both arteriolar (p = 0.33)and venular oxygen saturation (p = 0.79). Intraclass correlation coefficients for test–retest, short-term, and day-to-day repeatability were 0.84, 0.90, and 0.86 for arteriolar oxygen saturation and 0.92, 0.98, and 0.98 for retinal venular oxygen saturation. Oxygen saturation in retinal arteriolar and venular blood vessels can be measured by nonsimultaneous image acquisition technique using a conventional fundus camera with good repeatability.Sumeer SinghGunasekaran VeluRajiv RamanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sumeer Singh Gunasekaran Velu Rajiv Raman Development and Validation of Non simultaneous Retinal Image Acquisition–Based Retinal Oximeter
description	Abstract The purpose of this study was to develop and validate a tool for the measurement of retinal oxygen saturation using a conventional fundus camera–based nonsimultaneous imaging technique. Retinal oximetry setup comprising a conventional Zeiss FF450IR fundus camera, dual wavelength band-pass filters of wavelengths 570 and 600 nm were used. Image analysis was performed using MATLAB R2013b. All the study participants underwent comprehensive eye examination, fundus examination, complete hemogram analysis, and evaluation of systemic hemodynamics. Fundus images were captured by a nonsimultaneous retinal oximetry. A total of 45 subjects were included in the analysis. Median age of the subjects was 21 years ranging from 19 to 34 years. The median retinal arteriolar and venular oxygen saturation was 94.7% and 55.8%. Comparison of retinal oxygen saturation between three visits showed no statistically significant difference for both arteriolar (p = 0.33)and venular oxygen saturation (p = 0.79). Intraclass correlation coefficients for test–retest, short-term, and day-to-day repeatability were 0.84, 0.90, and 0.86 for arteriolar oxygen saturation and 0.92, 0.98, and 0.98 for retinal venular oxygen saturation. Oxygen saturation in retinal arteriolar and venular blood vessels can be measured by nonsimultaneous image acquisition technique using a conventional fundus camera with good repeatability.
format	article
author	Sumeer Singh Gunasekaran Velu Rajiv Raman
author_facet	Sumeer Singh Gunasekaran Velu Rajiv Raman
author_sort	Sumeer Singh
title	Development and Validation of Non simultaneous Retinal Image Acquisition–Based Retinal Oximeter
title_short	Development and Validation of Non simultaneous Retinal Image Acquisition–Based Retinal Oximeter
title_full	Development and Validation of Non simultaneous Retinal Image Acquisition–Based Retinal Oximeter
title_fullStr	Development and Validation of Non simultaneous Retinal Image Acquisition–Based Retinal Oximeter
title_full_unstemmed	Development and Validation of Non simultaneous Retinal Image Acquisition–Based Retinal Oximeter
title_sort	development and validation of non simultaneous retinal image acquisition–based retinal oximeter
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0b2e94a294814f1cb3ecbdaaa568276f
work_keys_str_mv	AT sumeersingh developmentandvalidationofnonsimultaneousretinalimageacquisitionbasedretinaloximeter AT gunasekaranvelu developmentandvalidationofnonsimultaneousretinalimageacquisitionbasedretinaloximeter AT rajivraman developmentandvalidationofnonsimultaneousretinalimageacquisitionbasedretinaloximeter
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Development and Validation of Non simultaneous Retinal Image Acquisition–Based Retinal Oximeter

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