MRI-based radiomics and ADC values are related to recurrence of endometrial carcinoma: a preliminary analysis

Abstract Background To identify predictive value of apparent diffusion coefficient (ADC) values and magnetic resonance imaging (MRI)-based radiomics for all recurrences in patients with endometrial carcinoma (EC). Methods One hundred and seventy-four EC patients who were treated with operation and f...

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Autores principales:	Kaiyue Zhang, Yu Zhang, Xin Fang, Jiangning Dong, Liting Qian
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Endometrial neoplasms Recurrence Risk factors Apparent diffusion coefficient Radiomics Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/0b31d29c11694e2aafba130f7da255bc
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spelling	oai:doaj.org-article:0b31d29c11694e2aafba130f7da255bc2021-11-28T12:27:46ZMRI-based radiomics and ADC values are related to recurrence of endometrial carcinoma: a preliminary analysis10.1186/s12885-021-08988-x1471-2407https://doaj.org/article/0b31d29c11694e2aafba130f7da255bc2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12885-021-08988-xhttps://doaj.org/toc/1471-2407Abstract Background To identify predictive value of apparent diffusion coefficient (ADC) values and magnetic resonance imaging (MRI)-based radiomics for all recurrences in patients with endometrial carcinoma (EC). Methods One hundred and seventy-four EC patients who were treated with operation and followed up in our institution were retrospectively reviewed, and the patients were divided into training and test group. Baseline clinicopathological features and mean ADC (ADCmean), minimum ADC (ADCmin), and maximum ADC (ADCmax) were analyzed. Radiomic parameters were extracted on T2 weighted images and screened by logistic regression, and then a radiomics signature was developed to calculate the radiomic score (radscore). In training group, Kaplan–Meier analysis was performed and a Cox regression model was used to evaluate the correlation between clinicopathological features, ADC values and radscore with recurrence, and verified in the test group. Results ADCmean showed inverse correlation with recurrence, while radscore was positively associated with recurrence. In univariate analyses, FIGO stage, pathological types, myometrial invasion, ADCmean, ADCmin and radscore were associated with recurrence. In the training group, multivariate Cox analysis showed that pathological types, ADCmean and radscore were independent risk factors for recurrence, which were verified in the test group. Conclusions ADCmean value and radscore were independent predictors of recurrence of EC, which can supplement prognostic information in addition to clinicopathological information and provide basis for individualized treatment and follow-up plan.Kaiyue ZhangYu ZhangXin FangJiangning DongLiting QianBMCarticleEndometrial neoplasmsRecurrenceRisk factorsApparent diffusion coefficientRadiomicsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Endometrial neoplasms Recurrence Risk factors Apparent diffusion coefficient Radiomics Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Endometrial neoplasms Recurrence Risk factors Apparent diffusion coefficient Radiomics Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Kaiyue Zhang Yu Zhang Xin Fang Jiangning Dong Liting Qian MRI-based radiomics and ADC values are related to recurrence of endometrial carcinoma: a preliminary analysis
description	Abstract Background To identify predictive value of apparent diffusion coefficient (ADC) values and magnetic resonance imaging (MRI)-based radiomics for all recurrences in patients with endometrial carcinoma (EC). Methods One hundred and seventy-four EC patients who were treated with operation and followed up in our institution were retrospectively reviewed, and the patients were divided into training and test group. Baseline clinicopathological features and mean ADC (ADCmean), minimum ADC (ADCmin), and maximum ADC (ADCmax) were analyzed. Radiomic parameters were extracted on T2 weighted images and screened by logistic regression, and then a radiomics signature was developed to calculate the radiomic score (radscore). In training group, Kaplan–Meier analysis was performed and a Cox regression model was used to evaluate the correlation between clinicopathological features, ADC values and radscore with recurrence, and verified in the test group. Results ADCmean showed inverse correlation with recurrence, while radscore was positively associated with recurrence. In univariate analyses, FIGO stage, pathological types, myometrial invasion, ADCmean, ADCmin and radscore were associated with recurrence. In the training group, multivariate Cox analysis showed that pathological types, ADCmean and radscore were independent risk factors for recurrence, which were verified in the test group. Conclusions ADCmean value and radscore were independent predictors of recurrence of EC, which can supplement prognostic information in addition to clinicopathological information and provide basis for individualized treatment and follow-up plan.
format	article
author	Kaiyue Zhang Yu Zhang Xin Fang Jiangning Dong Liting Qian
author_facet	Kaiyue Zhang Yu Zhang Xin Fang Jiangning Dong Liting Qian
author_sort	Kaiyue Zhang
title	MRI-based radiomics and ADC values are related to recurrence of endometrial carcinoma: a preliminary analysis
title_short	MRI-based radiomics and ADC values are related to recurrence of endometrial carcinoma: a preliminary analysis
title_full	MRI-based radiomics and ADC values are related to recurrence of endometrial carcinoma: a preliminary analysis
title_fullStr	MRI-based radiomics and ADC values are related to recurrence of endometrial carcinoma: a preliminary analysis
title_full_unstemmed	MRI-based radiomics and ADC values are related to recurrence of endometrial carcinoma: a preliminary analysis
title_sort	mri-based radiomics and adc values are related to recurrence of endometrial carcinoma: a preliminary analysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/0b31d29c11694e2aafba130f7da255bc
work_keys_str_mv	AT kaiyuezhang mribasedradiomicsandadcvaluesarerelatedtorecurrenceofendometrialcarcinomaapreliminaryanalysis AT yuzhang mribasedradiomicsandadcvaluesarerelatedtorecurrenceofendometrialcarcinomaapreliminaryanalysis AT xinfang mribasedradiomicsandadcvaluesarerelatedtorecurrenceofendometrialcarcinomaapreliminaryanalysis AT jiangningdong mribasedradiomicsandadcvaluesarerelatedtorecurrenceofendometrialcarcinomaapreliminaryanalysis AT litingqian mribasedradiomicsandadcvaluesarerelatedtorecurrenceofendometrialcarcinomaapreliminaryanalysis
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MRI-based radiomics and ADC values are related to recurrence of endometrial carcinoma: a preliminary analysis

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