Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer

Evolution of resistance is a common cause of cancer treatment failure and tumor progression. Here, the authors present a method for integrating evolutionary principles based on adaptive therapy into abiraterone therapy for metastatic castrate-resistant prostate cancer and show the positive results o...

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Autores principales: Jingsong Zhang, Jessica J. Cunningham, Joel S. Brown, Robert A. Gatenby
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/0b379e0e807646b6afb149c07b50f8a3
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Sumario:Evolution of resistance is a common cause of cancer treatment failure and tumor progression. Here, the authors present a method for integrating evolutionary principles based on adaptive therapy into abiraterone therapy for metastatic castrate-resistant prostate cancer and show the positive results of an interim analysis of a trial cohort.