Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer

Evolution of resistance is a common cause of cancer treatment failure and tumor progression. Here, the authors present a method for integrating evolutionary principles based on adaptive therapy into abiraterone therapy for metastatic castrate-resistant prostate cancer and show the positive results o...

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Autores principales:	Jingsong Zhang, Jessica J. Cunningham, Joel S. Brown, Robert A. Gatenby
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0b379e0e807646b6afb149c07b50f8a3
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spelling	oai:doaj.org-article:0b379e0e807646b6afb149c07b50f8a32021-12-02T15:38:47ZIntegrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer10.1038/s41467-017-01968-52041-1723https://doaj.org/article/0b379e0e807646b6afb149c07b50f8a32017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01968-5https://doaj.org/toc/2041-1723Evolution of resistance is a common cause of cancer treatment failure and tumor progression. Here, the authors present a method for integrating evolutionary principles based on adaptive therapy into abiraterone therapy for metastatic castrate-resistant prostate cancer and show the positive results of an interim analysis of a trial cohort.Jingsong ZhangJessica J. CunninghamJoel S. BrownRobert A. GatenbyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jingsong Zhang Jessica J. Cunningham Joel S. Brown Robert A. Gatenby Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer
description	Evolution of resistance is a common cause of cancer treatment failure and tumor progression. Here, the authors present a method for integrating evolutionary principles based on adaptive therapy into abiraterone therapy for metastatic castrate-resistant prostate cancer and show the positive results of an interim analysis of a trial cohort.
format	article
author	Jingsong Zhang Jessica J. Cunningham Joel S. Brown Robert A. Gatenby
author_facet	Jingsong Zhang Jessica J. Cunningham Joel S. Brown Robert A. Gatenby
author_sort	Jingsong Zhang
title	Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer
title_short	Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer
title_full	Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer
title_fullStr	Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer
title_full_unstemmed	Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer
title_sort	integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0b379e0e807646b6afb149c07b50f8a3
work_keys_str_mv	AT jingsongzhang integratingevolutionarydynamicsintotreatmentofmetastaticcastrateresistantprostatecancer AT jessicajcunningham integratingevolutionarydynamicsintotreatmentofmetastaticcastrateresistantprostatecancer AT joelsbrown integratingevolutionarydynamicsintotreatmentofmetastaticcastrateresistantprostatecancer AT robertagatenby integratingevolutionarydynamicsintotreatmentofmetastaticcastrateresistantprostatecancer
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Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer

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