Genes of the mitochondrial apoptotic pathway in Mytilus galloprovincialis.

Bivalves play vital roles in marine, brackish, freshwater and terrestrial habitats. In recent years, these ecosystems have become affected through anthropogenic activities. The ecological success of marine bivalves is based on the ability to modify their physiological functions in response to enviro...

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Autores principales:	Noelia Estévez-Calvar, Alejandro Romero, Antonio Figueras, Beatriz Novoa
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0b3a7644f9f84d619876cbf06bcb4ce8
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spelling	oai:doaj.org-article:0b3a7644f9f84d619876cbf06bcb4ce82021-11-18T07:48:27ZGenes of the mitochondrial apoptotic pathway in Mytilus galloprovincialis.1932-620310.1371/journal.pone.0061502https://doaj.org/article/0b3a7644f9f84d619876cbf06bcb4ce82013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23626691/?tool=EBIhttps://doaj.org/toc/1932-6203Bivalves play vital roles in marine, brackish, freshwater and terrestrial habitats. In recent years, these ecosystems have become affected through anthropogenic activities. The ecological success of marine bivalves is based on the ability to modify their physiological functions in response to environmental changes. One of the most important mechanisms involved in adaptive responses to environmental and biological stresses is apoptosis, which has been scarcely studied in mollusks, although the final consequence of this process, DNA fragmentation, has been frequently used for pollution monitoring. Environmental stressors induce apoptosis in molluscan cells via an intrinsic pathway. Many of the proteins involved in vertebrate apoptosis have been recognized in model invertebrates; however, this process might not be universally conserved. Mytilus galloprovincialis is presented here as a new model to study the linkage between molecular mechanisms that mediate apoptosis and marine bivalve ecological adaptations. Therefore, it is strictly necessary to identify the key elements involved in bivalve apoptosis. In the present study, six mitochondrial apoptotic-related genes were characterized, and their gene expression profiles following UV irradiation were evaluated. This is the first step for the development of potential biomarkers to assess the biological responses of marine organisms to stress. The results confirmed that apoptosis and, more specifically, the expression of the genes involved in this process can be used to assess the biological responses of marine organisms to stress.Noelia Estévez-CalvarAlejandro RomeroAntonio FiguerasBeatriz NovoaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e61502 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Noelia Estévez-Calvar Alejandro Romero Antonio Figueras Beatriz Novoa Genes of the mitochondrial apoptotic pathway in Mytilus galloprovincialis.
description	Bivalves play vital roles in marine, brackish, freshwater and terrestrial habitats. In recent years, these ecosystems have become affected through anthropogenic activities. The ecological success of marine bivalves is based on the ability to modify their physiological functions in response to environmental changes. One of the most important mechanisms involved in adaptive responses to environmental and biological stresses is apoptosis, which has been scarcely studied in mollusks, although the final consequence of this process, DNA fragmentation, has been frequently used for pollution monitoring. Environmental stressors induce apoptosis in molluscan cells via an intrinsic pathway. Many of the proteins involved in vertebrate apoptosis have been recognized in model invertebrates; however, this process might not be universally conserved. Mytilus galloprovincialis is presented here as a new model to study the linkage between molecular mechanisms that mediate apoptosis and marine bivalve ecological adaptations. Therefore, it is strictly necessary to identify the key elements involved in bivalve apoptosis. In the present study, six mitochondrial apoptotic-related genes were characterized, and their gene expression profiles following UV irradiation were evaluated. This is the first step for the development of potential biomarkers to assess the biological responses of marine organisms to stress. The results confirmed that apoptosis and, more specifically, the expression of the genes involved in this process can be used to assess the biological responses of marine organisms to stress.
format	article
author	Noelia Estévez-Calvar Alejandro Romero Antonio Figueras Beatriz Novoa
author_facet	Noelia Estévez-Calvar Alejandro Romero Antonio Figueras Beatriz Novoa
author_sort	Noelia Estévez-Calvar
title	Genes of the mitochondrial apoptotic pathway in Mytilus galloprovincialis.
title_short	Genes of the mitochondrial apoptotic pathway in Mytilus galloprovincialis.
title_full	Genes of the mitochondrial apoptotic pathway in Mytilus galloprovincialis.
title_fullStr	Genes of the mitochondrial apoptotic pathway in Mytilus galloprovincialis.
title_full_unstemmed	Genes of the mitochondrial apoptotic pathway in Mytilus galloprovincialis.
title_sort	genes of the mitochondrial apoptotic pathway in mytilus galloprovincialis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/0b3a7644f9f84d619876cbf06bcb4ce8
work_keys_str_mv	AT noeliaestevezcalvar genesofthemitochondrialapoptoticpathwayinmytilusgalloprovincialis AT alejandroromero genesofthemitochondrialapoptoticpathwayinmytilusgalloprovincialis AT antoniofigueras genesofthemitochondrialapoptoticpathwayinmytilusgalloprovincialis AT beatriznovoa genesofthemitochondrialapoptoticpathwayinmytilusgalloprovincialis
_version_	1718422892873515008

Genes of the mitochondrial apoptotic pathway in Mytilus galloprovincialis.

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