Time to reconsider Spitzoid neoplasms?

Background: Spitzoid neoplasms may pose significant diagnostic problems because in a fraction of them it is quite difficult or impossible to establish if they are benign or malignant lesions. An extraordinarily large number of studies have been made in attempts to solve this problem; regrettably, t...

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Autor principal:	Carmelo Urso
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2016
Materias:	Spitz tumors Spitz nevus atypical Spitz tumor Spitzoid melanoma melanoma Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/0b3aadf0748a493ba4bb93595e756cd4
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spelling	oai:doaj.org-article:0b3aadf0748a493ba4bb93595e756cd42021-11-17T08:31:14ZTime to reconsider Spitzoid neoplasms?10.5826/dpc.0602a082160-9381https://doaj.org/article/0b3aadf0748a493ba4bb93595e756cd42016-04-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/107https://doaj.org/toc/2160-9381 Background: Spitzoid neoplasms may pose significant diagnostic problems because in a fraction of them it is quite difficult or impossible to establish if they are benign or malignant lesions. An extraordinarily large number of studies have been made in attempts to solve this problem; regrettably, the histological criteria proposed and the various special sophisticated techniques employed have proven to be ineffective in making this distinction with confidence. Objectives: To explore the possible causes for this diagnostic failure and an attempt to identify the source of this problem. Method: A historical and technical analysis of the specialized literature is performed, critically evaluating the main points of this controversial topic. Results: The reasons for the diagnostic failure in Spitzoid neoplasms are not clear but could be the result of inappropriate conceptual classification. The analysis of available data and a rational review of old and new assumptions and concepts may suggest a different classification for Spitzoid neoplasms: Spitz nevus, atypical Spitz tumor and Spitzoid melanoma, rather than being three different tumors that are difficult or impossible to distinguish with assurance, could be viewed as one unique entity, Spitz tumor (ST). A Spitz tumor is a low-grade malignant neoplasm, in which the amount of intrinsic risk is variable, ranging from very low to high (ST1, ST2, ST3), and malignant potential could be estimated. Conclusions: The proposed alternative classification of Spitzoid neoplasms as a unique tumor may help in overcoming the difficulty in diagnosis of these tumors. Carmelo UrsoMattioli1885articleSpitz tumorsSpitz nevusatypical Spitz tumorSpitzoid melanomamelanomaDermatologyRL1-803ENDermatology Practical & Conceptual (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Spitz tumors Spitz nevus atypical Spitz tumor Spitzoid melanoma melanoma Dermatology RL1-803
spellingShingle	Spitz tumors Spitz nevus atypical Spitz tumor Spitzoid melanoma melanoma Dermatology RL1-803 Carmelo Urso Time to reconsider Spitzoid neoplasms?
description	Background: Spitzoid neoplasms may pose significant diagnostic problems because in a fraction of them it is quite difficult or impossible to establish if they are benign or malignant lesions. An extraordinarily large number of studies have been made in attempts to solve this problem; regrettably, the histological criteria proposed and the various special sophisticated techniques employed have proven to be ineffective in making this distinction with confidence. Objectives: To explore the possible causes for this diagnostic failure and an attempt to identify the source of this problem. Method: A historical and technical analysis of the specialized literature is performed, critically evaluating the main points of this controversial topic. Results: The reasons for the diagnostic failure in Spitzoid neoplasms are not clear but could be the result of inappropriate conceptual classification. The analysis of available data and a rational review of old and new assumptions and concepts may suggest a different classification for Spitzoid neoplasms: Spitz nevus, atypical Spitz tumor and Spitzoid melanoma, rather than being three different tumors that are difficult or impossible to distinguish with assurance, could be viewed as one unique entity, Spitz tumor (ST). A Spitz tumor is a low-grade malignant neoplasm, in which the amount of intrinsic risk is variable, ranging from very low to high (ST1, ST2, ST3), and malignant potential could be estimated. Conclusions: The proposed alternative classification of Spitzoid neoplasms as a unique tumor may help in overcoming the difficulty in diagnosis of these tumors.
format	article
author	Carmelo Urso
author_facet	Carmelo Urso
author_sort	Carmelo Urso
title	Time to reconsider Spitzoid neoplasms?
title_short	Time to reconsider Spitzoid neoplasms?
title_full	Time to reconsider Spitzoid neoplasms?
title_fullStr	Time to reconsider Spitzoid neoplasms?
title_full_unstemmed	Time to reconsider Spitzoid neoplasms?
title_sort	time to reconsider spitzoid neoplasms?
publisher	Mattioli1885
publishDate	2016
url	https://doaj.org/article/0b3aadf0748a493ba4bb93595e756cd4
work_keys_str_mv	AT carmelourso timetoreconsiderspitzoidneoplasms
_version_	1718425716699168768

Time to reconsider Spitzoid neoplasms?

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